JPS5798258A - Beta-lactamase inhibitor composition - Google Patents

Beta-lactamase inhibitor composition

Info

Publication number
JPS5798258A
JPS5798258A JP56170634A JP17063481A JPS5798258A JP S5798258 A JPS5798258 A JP S5798258A JP 56170634 A JP56170634 A JP 56170634A JP 17063481 A JP17063481 A JP 17063481A JP S5798258 A JPS5798258 A JP S5798258A
Authority
JP
Japan
Prior art keywords
compound shown
formula
lactamase inhibitor
formulai
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56170634A
Other languages
Japanese (ja)
Inventor
Taisuke Matsuo
Mitsuzo Kuno
Kenji Okonogi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to CA000391401A priority Critical patent/CA1338539C/en
Publication of JPS5798258A publication Critical patent/JPS5798258A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3

Abstract

NEW MATERIAL:A 1-sulfo-2-oxoacetidine derivative shown by the formulaI(R1 is amino which may be acylated or protected; X is H or methoxy).
EXAMPLE: Sodium 3-{D-2-[(3-furfuryldideneamino-2-oxoimidazolidine-1-yl)carboxamide]propionamide}2-oxoazetidine-1-sulfonate.
USE: A β-lactamase inhibitor. Used in combination with a β-lactam type antibiotic which is medicated to remedy or to prevent bactrium infectious diseases of men and cattle.
PROCESS: A compound shown by the formula II is reacted with sulfuric anhydride or its reactive derivative at 10W40°C to give a compound shown by the formulaI. The compound shown by the formula II is obtained by oxidizing a compound shown by the formula III with an alkaline(earth) metal permaganate in a solvent.
COPYRIGHT: (C)1982,JPO&Japio
JP56170634A 1980-10-23 1981-10-23 Beta-lactamase inhibitor composition Pending JPS5798258A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000391401A CA1338539C (en) 1980-12-04 1981-12-03 1-sulfo-2-oxoazetidine derivatives and their production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1980/000255 WO1982001551A1 (en) 1980-10-23 1980-10-23 Beta-lactamase-inhibiting composition

Publications (1)

Publication Number Publication Date
JPS5798258A true JPS5798258A (en) 1982-06-18

Family

ID=13706102

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56170634A Pending JPS5798258A (en) 1980-10-23 1981-10-23 Beta-lactamase inhibitor composition

Country Status (2)

Country Link
JP (1) JPS5798258A (en)
WO (1) WO1982001551A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002534500A (en) * 1999-01-15 2002-10-15 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト New alpha-sulfenimino acid derivatives
JP2002356427A (en) * 2001-05-30 2002-12-13 Shionogi & Co Ltd beta-LACTAMASE INHIBITOR
JP2016520658A (en) * 2013-06-13 2016-07-14 アンタビオ エスアーエス Antibacterial thiazolecarboxylic acid

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002534500A (en) * 1999-01-15 2002-10-15 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト New alpha-sulfenimino acid derivatives
JP2002356427A (en) * 2001-05-30 2002-12-13 Shionogi & Co Ltd beta-LACTAMASE INHIBITOR
JP2016520658A (en) * 2013-06-13 2016-07-14 アンタビオ エスアーエス Antibacterial thiazolecarboxylic acid

Also Published As

Publication number Publication date
WO1982001551A1 (en) 1982-05-13

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