JPS5455592A - Preparation of antibiotics containing beta-lactam ring - Google Patents

Preparation of antibiotics containing beta-lactam ring

Info

Publication number
JPS5455592A
JPS5455592A JP12177377A JP12177377A JPS5455592A JP S5455592 A JPS5455592 A JP S5455592A JP 12177377 A JP12177377 A JP 12177377A JP 12177377 A JP12177377 A JP 12177377A JP S5455592 A JPS5455592 A JP S5455592A
Authority
JP
Japan
Prior art keywords
formula
derivative
seleninic
reacted
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12177377A
Other languages
Japanese (ja)
Inventor
Tetsuo Hiraoka
Takeo Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP12177377A priority Critical patent/JPS5455592A/en
Publication of JPS5455592A publication Critical patent/JPS5455592A/en
Pending legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: A seleninic amide derivative is formed in the 7-or 6-positon of wide ranges of cephalosporins and penicillins by using a seleniny halide, thereby permitting ready introduction of substituent in the position in high yield.
CONSTITUTION: 7-Aminocephem or 6-aminopenam derivative of formula II [R3 is protected or unprotected carboxyl group; Z is group of formula IX or X (R4 is unreactive group)] is reacted with a seleninyl halide of formula III (R1 is substituted aromatic group; X is halogen) in the presence of a base to form seleninic amide derivative formula IV (R2 is lower alkyl). The resultant seleninic amide is oxidized with an oxidizing agent to form a seleninic imino derivative of formula V, which is reacted with a compound of formula VI (R2 is lower alkyl). The product of fomulaVII is reacted with a compound of fomula VIII (R5 is residue of carboxylic acid) to prepare 7-alkoxyacylaminocephem or penam derivative of formula I
COPYRIGHT: (C)1979,JPO&Japio
JP12177377A 1977-10-11 1977-10-11 Preparation of antibiotics containing beta-lactam ring Pending JPS5455592A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12177377A JPS5455592A (en) 1977-10-11 1977-10-11 Preparation of antibiotics containing beta-lactam ring

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12177377A JPS5455592A (en) 1977-10-11 1977-10-11 Preparation of antibiotics containing beta-lactam ring

Publications (1)

Publication Number Publication Date
JPS5455592A true JPS5455592A (en) 1979-05-02

Family

ID=14819520

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12177377A Pending JPS5455592A (en) 1977-10-11 1977-10-11 Preparation of antibiotics containing beta-lactam ring

Country Status (1)

Country Link
JP (1) JPS5455592A (en)

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