JPS5785321A - Agent for promoting absorption of acylamino acid, and drug base and preparation for rectal administration containing the same - Google Patents
Agent for promoting absorption of acylamino acid, and drug base and preparation for rectal administration containing the sameInfo
- Publication number
- JPS5785321A JPS5785321A JP16112180A JP16112180A JPS5785321A JP S5785321 A JPS5785321 A JP S5785321A JP 16112180 A JP16112180 A JP 16112180A JP 16112180 A JP16112180 A JP 16112180A JP S5785321 A JPS5785321 A JP S5785321A
- Authority
- JP
- Japan
- Prior art keywords
- preparation
- acylamino acid
- agent
- rectal administration
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
PURPOSE: To provide the titled preparation administrable safely to the rectrum without stimmulating the rectum nor damaging the rectal mucosa, by using at least one compound selected from specific N-acylamino acids and their salts, as a components.
CONSTITUTION: A preparation for rectal administration having excellent transferability of the pharmacologically active substance, is prepared by compounding (A) at least one compound selected from N-acylamino acid having ≥9 total carbon number (having 2W18C acyl group) and their salts[e.g., the compound of formula (R1 is H, alkyl, allyl, etc.; R2 is 2W18C acyl), e.g. N-propionoyl-L- phenylalanine]with (B) an arbitrary pharmacologically active substance[e.g. antibacterial agent having β-lactam ring (e.g. penicillin, etc.), aminoglycoside-type antibiotic substance, polysaccharide-type drug, etc.], and if necessary (C) a base, surface-active agent, antioxidant, preservative, diluent, etc. The amount of the acylamino acid in the composition is 0.5W50wt%.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16112180A JPS5785321A (en) | 1980-11-14 | 1980-11-14 | Agent for promoting absorption of acylamino acid, and drug base and preparation for rectal administration containing the same |
US06/246,953 US4442090A (en) | 1980-11-09 | 1981-03-24 | Absorption-promoting compounds, compositions thereof with pharmaceuticals and/or bases for rectal administration and method of use |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16112180A JPS5785321A (en) | 1980-11-14 | 1980-11-14 | Agent for promoting absorption of acylamino acid, and drug base and preparation for rectal administration containing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5785321A true JPS5785321A (en) | 1982-05-28 |
Family
ID=15728995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16112180A Pending JPS5785321A (en) | 1980-11-09 | 1980-11-14 | Agent for promoting absorption of acylamino acid, and drug base and preparation for rectal administration containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5785321A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997045122A1 (en) * | 1996-05-31 | 1997-12-04 | Kanebo, Limited | Suppositories |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56118013A (en) * | 1980-02-25 | 1981-09-16 | Teijin Ltd | Calcitonin pharmaceutical and its preparation |
-
1980
- 1980-11-14 JP JP16112180A patent/JPS5785321A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56118013A (en) * | 1980-02-25 | 1981-09-16 | Teijin Ltd | Calcitonin pharmaceutical and its preparation |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997045122A1 (en) * | 1996-05-31 | 1997-12-04 | Kanebo, Limited | Suppositories |
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