JPS5793923A - Preparation of 2-(4-isobutylphenyl) propionic acid - Google Patents
Preparation of 2-(4-isobutylphenyl) propionic acidInfo
- Publication number
- JPS5793923A JPS5793923A JP11090081A JP11090081A JPS5793923A JP S5793923 A JPS5793923 A JP S5793923A JP 11090081 A JP11090081 A JP 11090081A JP 11090081 A JP11090081 A JP 11090081A JP S5793923 A JPS5793923 A JP S5793923A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- isobutylphenyl
- hydroxypropionamide
- raw material
- exchange resin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain the titled compound useful as an anti-inflammatory and analgesic agent in high yield, by dehydrating 2-(4'-isobutylpheynl)-2-hydroxypropionamide as a raw material in the presence of a cation exchange resin under heating, and hydrolyzing and reducing the resultant compound.
CONSTITUTION: 2-(4'-Isobytylphenyl)-2-hydroxypropionamide of formulaI(R is isobutyl) is dehydrated in the presence of a cation exchange resin in an inert solvent unde heating at 70W110°C for 2W6hr to produce 2-(4'-isobutylphenyl) acrylamide of formula II in high yield. The resultant compound is then hydrolyzed and reduced with H2 in the presence of a caustic alkali and a hydrogenating catalyst in water or a mixed solvent of water with an inert solvent at a hydrogen pressure of 4W10kg/cm2.G at 100W120°C to give the aimed compound.
EFFECT: The aimed compound can be prepared in easy steps under mild reaction conditions industrially and advantageously without requiring a special raw material chemical.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11090081A JPS5842854B2 (en) | 1981-07-17 | 1981-07-17 | Method for producing 2-(4-isobutylphenyl)propionic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11090081A JPS5842854B2 (en) | 1981-07-17 | 1981-07-17 | Method for producing 2-(4-isobutylphenyl)propionic acid |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6759976A Division JPS52151144A (en) | 1976-06-11 | 1976-06-11 | Preparation of 2-substituted-acrylic amide and 2-substituted-propionic acid derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5793923A true JPS5793923A (en) | 1982-06-11 |
JPS5842854B2 JPS5842854B2 (en) | 1983-09-22 |
Family
ID=14547520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11090081A Expired JPS5842854B2 (en) | 1981-07-17 | 1981-07-17 | Method for producing 2-(4-isobutylphenyl)propionic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5842854B2 (en) |
-
1981
- 1981-07-17 JP JP11090081A patent/JPS5842854B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS5842854B2 (en) | 1983-09-22 |
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