JPS5793923A - Preparation of 2-(4-isobutylphenyl) propionic acid - Google Patents

Preparation of 2-(4-isobutylphenyl) propionic acid

Info

Publication number
JPS5793923A
JPS5793923A JP11090081A JP11090081A JPS5793923A JP S5793923 A JPS5793923 A JP S5793923A JP 11090081 A JP11090081 A JP 11090081A JP 11090081 A JP11090081 A JP 11090081A JP S5793923 A JPS5793923 A JP S5793923A
Authority
JP
Japan
Prior art keywords
compound
isobutylphenyl
hydroxypropionamide
raw material
exchange resin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11090081A
Other languages
Japanese (ja)
Other versions
JPS5842854B2 (en
Inventor
Kazumi Kobayashi
Yoshitsugu Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP11090081A priority Critical patent/JPS5842854B2/en
Publication of JPS5793923A publication Critical patent/JPS5793923A/en
Publication of JPS5842854B2 publication Critical patent/JPS5842854B2/en
Expired legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled compound useful as an anti-inflammatory and analgesic agent in high yield, by dehydrating 2-(4'-isobutylpheynl)-2-hydroxypropionamide as a raw material in the presence of a cation exchange resin under heating, and hydrolyzing and reducing the resultant compound.
CONSTITUTION: 2-(4'-Isobytylphenyl)-2-hydroxypropionamide of formulaI(R is isobutyl) is dehydrated in the presence of a cation exchange resin in an inert solvent unde heating at 70W110°C for 2W6hr to produce 2-(4'-isobutylphenyl) acrylamide of formula II in high yield. The resultant compound is then hydrolyzed and reduced with H2 in the presence of a caustic alkali and a hydrogenating catalyst in water or a mixed solvent of water with an inert solvent at a hydrogen pressure of 4W10kg/cm2.G at 100W120°C to give the aimed compound.
EFFECT: The aimed compound can be prepared in easy steps under mild reaction conditions industrially and advantageously without requiring a special raw material chemical.
COPYRIGHT: (C)1982,JPO&Japio
JP11090081A 1981-07-17 1981-07-17 Method for producing 2-(4-isobutylphenyl)propionic acid Expired JPS5842854B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11090081A JPS5842854B2 (en) 1981-07-17 1981-07-17 Method for producing 2-(4-isobutylphenyl)propionic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11090081A JPS5842854B2 (en) 1981-07-17 1981-07-17 Method for producing 2-(4-isobutylphenyl)propionic acid

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP6759976A Division JPS52151144A (en) 1976-06-11 1976-06-11 Preparation of 2-substituted-acrylic amide and 2-substituted-propionic acid derivatives

Publications (2)

Publication Number Publication Date
JPS5793923A true JPS5793923A (en) 1982-06-11
JPS5842854B2 JPS5842854B2 (en) 1983-09-22

Family

ID=14547520

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11090081A Expired JPS5842854B2 (en) 1981-07-17 1981-07-17 Method for producing 2-(4-isobutylphenyl)propionic acid

Country Status (1)

Country Link
JP (1) JPS5842854B2 (en)

Also Published As

Publication number Publication date
JPS5842854B2 (en) 1983-09-22

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