JPS5775998A - Preparation of cytidine diphosphate choline ester - Google Patents
Preparation of cytidine diphosphate choline esterInfo
- Publication number
- JPS5775998A JPS5775998A JP15140480A JP15140480A JPS5775998A JP S5775998 A JPS5775998 A JP S5775998A JP 15140480 A JP15140480 A JP 15140480A JP 15140480 A JP15140480 A JP 15140480A JP S5775998 A JPS5775998 A JP S5775998A
- Authority
- JP
- Japan
- Prior art keywords
- phosphorylcholine
- cytidine
- preparation
- 1mol
- pref
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Saccharide Compounds (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as a remedy for obnubilation caused by brain lesion, economically, in an industrial scale, by condensing cytidine- 5'-phosphate with a metal salt of phosphorylcholine halide in the presence of a specific amount of cyanuric chloride.
CONSTITUTION: The objective compound can be obtained by condensing (A) cytidine-5'-phosphate with (B) a metal salt of phosphorylcholine halide (e.g. calcium salt of phosphorylcholine chloride) in the presence of ≥1mol, pref. 2W4mol, based on 1mol of the component B, of cyanuric chloride, pref. in an organic solvent such as dimethylformamide, etc., e.g. at 0W40°C for 1hr.
EFFECT: The objective compound can be prepared with a simple process, in high yield, without using expensive reagents.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15140480A JPS5775998A (en) | 1980-10-30 | 1980-10-30 | Preparation of cytidine diphosphate choline ester |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15140480A JPS5775998A (en) | 1980-10-30 | 1980-10-30 | Preparation of cytidine diphosphate choline ester |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5775998A true JPS5775998A (en) | 1982-05-12 |
Family
ID=15517842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15140480A Pending JPS5775998A (en) | 1980-10-30 | 1980-10-30 | Preparation of cytidine diphosphate choline ester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5775998A (en) |
-
1980
- 1980-10-30 JP JP15140480A patent/JPS5775998A/en active Pending
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