JPS5775998A - Preparation of cytidine diphosphate choline ester - Google Patents

Preparation of cytidine diphosphate choline ester

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Publication number
JPS5775998A
JPS5775998A JP15140480A JP15140480A JPS5775998A JP S5775998 A JPS5775998 A JP S5775998A JP 15140480 A JP15140480 A JP 15140480A JP 15140480 A JP15140480 A JP 15140480A JP S5775998 A JPS5775998 A JP S5775998A
Authority
JP
Japan
Prior art keywords
phosphorylcholine
cytidine
preparation
1mol
pref
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15140480A
Other languages
Japanese (ja)
Inventor
Osamu Maruyama
Tadashi Sato
Takeshi Kawashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kohjin Holdings Co Ltd
Original Assignee
Kohjin Holdings Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kohjin Holdings Co Ltd filed Critical Kohjin Holdings Co Ltd
Priority to JP15140480A priority Critical patent/JPS5775998A/en
Publication of JPS5775998A publication Critical patent/JPS5775998A/en
Pending legal-status Critical Current

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Abstract

PURPOSE: To prepare the titled compound useful as a remedy for obnubilation caused by brain lesion, economically, in an industrial scale, by condensing cytidine- 5'-phosphate with a metal salt of phosphorylcholine halide in the presence of a specific amount of cyanuric chloride.
CONSTITUTION: The objective compound can be obtained by condensing (A) cytidine-5'-phosphate with (B) a metal salt of phosphorylcholine halide (e.g. calcium salt of phosphorylcholine chloride) in the presence of ≥1mol, pref. 2W4mol, based on 1mol of the component B, of cyanuric chloride, pref. in an organic solvent such as dimethylformamide, etc., e.g. at 0W40°C for 1hr.
EFFECT: The objective compound can be prepared with a simple process, in high yield, without using expensive reagents.
COPYRIGHT: (C)1982,JPO&Japio
JP15140480A 1980-10-30 1980-10-30 Preparation of cytidine diphosphate choline ester Pending JPS5775998A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15140480A JPS5775998A (en) 1980-10-30 1980-10-30 Preparation of cytidine diphosphate choline ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15140480A JPS5775998A (en) 1980-10-30 1980-10-30 Preparation of cytidine diphosphate choline ester

Publications (1)

Publication Number Publication Date
JPS5775998A true JPS5775998A (en) 1982-05-12

Family

ID=15517842

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15140480A Pending JPS5775998A (en) 1980-10-30 1980-10-30 Preparation of cytidine diphosphate choline ester

Country Status (1)

Country Link
JP (1) JPS5775998A (en)

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