JPS5775997A - Preparation of cytidine diphosphate choline ester - Google Patents

Preparation of cytidine diphosphate choline ester

Info

Publication number
JPS5775997A
JPS5775997A JP15062980A JP15062980A JPS5775997A JP S5775997 A JPS5775997 A JP S5775997A JP 15062980 A JP15062980 A JP 15062980A JP 15062980 A JP15062980 A JP 15062980A JP S5775997 A JPS5775997 A JP S5775997A
Authority
JP
Japan
Prior art keywords
phosphorylcholine
cytidine
preparation
1mol
pref
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP15062980A
Other languages
Japanese (ja)
Other versions
JPS6043077B2 (en
Inventor
Osamu Maruyama
Tadashi Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kohjin Holdings Co Ltd
Original Assignee
Kohjin Holdings Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kohjin Holdings Co Ltd filed Critical Kohjin Holdings Co Ltd
Priority to JP15062980A priority Critical patent/JPS6043077B2/en
Publication of JPS5775997A publication Critical patent/JPS5775997A/en
Publication of JPS6043077B2 publication Critical patent/JPS6043077B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Saccharide Compounds (AREA)

Abstract

PURPOSE: To prepare the titled compound useful as a remedy for obnubilation caused by brain lesion, economically, in an industrial scale, by condensing cytidine- 5'-phosphate with a metal salt of phosphorylcholine halide in the presence of a specific amount of thionyl chloride.
CONSTITUTION: The objective compound can be obtained by condensing (A) cytidine-5'-phosphate with (B) a metal salt of phosphorylcholine halide (e.g. calcium salt of phosphorylcholine chloride) in the presence of ≥1mol, pref. 2W4mol, based on 1mol of the component B, of thionyl chloride, pref. in an organic solvent such as dimethylformamide, etc., e.g. at 0W40°C for 1hr.
EFFECT: The objective compound can be prepared with a simple process, in high yield, without using expensive reagents.
COPYRIGHT: (C)1982,JPO&Japio
JP15062980A 1980-10-29 1980-10-29 Production method of choline cytidine diphosphate Expired JPS6043077B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15062980A JPS6043077B2 (en) 1980-10-29 1980-10-29 Production method of choline cytidine diphosphate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15062980A JPS6043077B2 (en) 1980-10-29 1980-10-29 Production method of choline cytidine diphosphate

Publications (2)

Publication Number Publication Date
JPS5775997A true JPS5775997A (en) 1982-05-12
JPS6043077B2 JPS6043077B2 (en) 1985-09-26

Family

ID=15501028

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15062980A Expired JPS6043077B2 (en) 1980-10-29 1980-10-29 Production method of choline cytidine diphosphate

Country Status (1)

Country Link
JP (1) JPS6043077B2 (en)

Also Published As

Publication number Publication date
JPS6043077B2 (en) 1985-09-26

Similar Documents

Publication Publication Date Title
JPS5791996A (en) Novel nucleoside derivative and its preparation
JPS5775997A (en) Preparation of cytidine diphosphate choline ester
JPS5775998A (en) Preparation of cytidine diphosphate choline ester
JPS5775999A (en) Preparation of cytidine diphosphate choline ester
JPS5340737A (en) Preparation of cyanophenol
JPS5437096A (en) Method of procucing pure phosphoric acid
JPS5677298A (en) Movel 5-fluorouridine derivative and its preparation
JPS53110800A (en) Separation method of hydrogen isotope
JPS53133283A (en) High polymers bonded to adenine nucleotide derivatives
JPS51142098A (en) A process for preparing a polyester
JPS57108099A (en) Preparation of choline cytidine diphosphate
JPS55108838A (en) Preparation of arkyl-1-chloro-2-oxocycloalkane carboxylate
JPS53119820A (en) Preparation of alkali aminodiacetate
JPS5427582A (en) Preparation of dinucleoside triphosphate
JPS5392732A (en) Novel process for preparation of nitrile derivatives
ES8206522A1 (en) Process for the Preparation of Apovincaminic Acid Esters
JPS53101323A (en) Preparation of 2-substd-2-sulfenyl-1,3-dicarbonyl copound
JPS52105118A (en) Preparation fluorovinylether containing ester group
JPS5422363A (en) Preparation of thiophene-substituted fatty acid halide
JPS5241293A (en) Method of manufacturing glucose-1-phosphate and glucose-6-phosphate
JPS5599199A (en) Reagent for qualitative analysis of gamma-glutamyl transpeptidase and preparation of substrate
JPS53119882A (en) Preparation of aminopyrazinecarboxylic acid esters
JPS5257171A (en) Process for preparing 2-amino (2) thiazoline-4-carboxylic acid
JPS54157566A (en) Preparation of nucleoside
JPS53112815A (en) Preparation of derivative of aliphatic isothiocyanic acid having basic substituent