JPS5775997A - Preparation of cytidine diphosphate choline ester - Google Patents
Preparation of cytidine diphosphate choline esterInfo
- Publication number
- JPS5775997A JPS5775997A JP15062980A JP15062980A JPS5775997A JP S5775997 A JPS5775997 A JP S5775997A JP 15062980 A JP15062980 A JP 15062980A JP 15062980 A JP15062980 A JP 15062980A JP S5775997 A JPS5775997 A JP S5775997A
- Authority
- JP
- Japan
- Prior art keywords
- phosphorylcholine
- cytidine
- preparation
- 1mol
- pref
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RZZPDXZPRHQOCG-OJAKKHQRSA-O CDP-choline(1+) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-O 0.000 title 1
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- IERHLVCPSMICTF-XVFCMESISA-N cytidine 5'-monophosphate Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O1 IERHLVCPSMICTF-XVFCMESISA-N 0.000 abstract 2
- IERHLVCPSMICTF-UHFFFAOYSA-N cytidine monophosphate Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(COP(O)(O)=O)O1 IERHLVCPSMICTF-UHFFFAOYSA-N 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 229950004354 phosphorylcholine Drugs 0.000 abstract 2
- -1 phosphorylcholine halide Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010051290 Central nervous system lesion Diseases 0.000 abstract 1
- 206010012373 Depressed level of consciousness Diseases 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- PYJNAPOPMIJKJZ-UHFFFAOYSA-N phosphorylcholine chloride Chemical compound [Cl-].C[N+](C)(C)CCOP(O)(O)=O PYJNAPOPMIJKJZ-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as a remedy for obnubilation caused by brain lesion, economically, in an industrial scale, by condensing cytidine- 5'-phosphate with a metal salt of phosphorylcholine halide in the presence of a specific amount of thionyl chloride.
CONSTITUTION: The objective compound can be obtained by condensing (A) cytidine-5'-phosphate with (B) a metal salt of phosphorylcholine halide (e.g. calcium salt of phosphorylcholine chloride) in the presence of ≥1mol, pref. 2W4mol, based on 1mol of the component B, of thionyl chloride, pref. in an organic solvent such as dimethylformamide, etc., e.g. at 0W40°C for 1hr.
EFFECT: The objective compound can be prepared with a simple process, in high yield, without using expensive reagents.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15062980A JPS6043077B2 (en) | 1980-10-29 | 1980-10-29 | Production method of choline cytidine diphosphate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15062980A JPS6043077B2 (en) | 1980-10-29 | 1980-10-29 | Production method of choline cytidine diphosphate |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5775997A true JPS5775997A (en) | 1982-05-12 |
JPS6043077B2 JPS6043077B2 (en) | 1985-09-26 |
Family
ID=15501028
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15062980A Expired JPS6043077B2 (en) | 1980-10-29 | 1980-10-29 | Production method of choline cytidine diphosphate |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6043077B2 (en) |
-
1980
- 1980-10-29 JP JP15062980A patent/JPS6043077B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS6043077B2 (en) | 1985-09-26 |
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