JPS5775994A - Novel aprosamine derivative - Google Patents
Novel aprosamine derivativeInfo
- Publication number
- JPS5775994A JPS5775994A JP55150926A JP15092680A JPS5775994A JP S5775994 A JPS5775994 A JP S5775994A JP 55150926 A JP55150926 A JP 55150926A JP 15092680 A JP15092680 A JP 15092680A JP S5775994 A JPS5775994 A JP S5775994A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- aprosamine
- protecting
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- SNJPWAGLRQBAAQ-VFWJJLHLSA-N aprosamine Chemical class O([C@@H]1[C@H](N)C[C@@H]2OC(O)[C@H]([C@H]([C@H]2O1)O)NC)[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O SNJPWAGLRQBAAQ-VFWJJLHLSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract 2
- -1 3-Amino-2-hydroxypropyl Chemical group 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- XZNUGFQTQHRASN-XQENGBIVSA-N apramycin Chemical compound O([C@H]1O[C@@H]2[C@H](O)[C@@H]([C@H](O[C@H]2C[C@H]1N)O[C@@H]1[C@@H]([C@@H](O)[C@H](N)[C@@H](CO)O1)O)NC)[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O XZNUGFQTQHRASN-XQENGBIVSA-N 0.000 abstract 1
- 229950006334 apramycin Drugs 0.000 abstract 1
- 239000003899 bactericide agent Substances 0.000 abstract 1
- 238000006482 condensation reaction Methods 0.000 abstract 1
- 239000000645 desinfectant Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55150926A JPS5775994A (en) | 1980-10-27 | 1980-10-27 | Novel aprosamine derivative |
| FR8119510A FR2492828A1 (fr) | 1980-10-27 | 1981-10-16 | Derives d'aprosamine a activite antimicrobienne contre les bacteries gram-positives et gram-negatives |
| US06/313,971 US4362866A (en) | 1980-10-27 | 1981-10-22 | Aprosamine derivatives |
| BE0/206352A BE890873A (fr) | 1980-10-27 | 1981-10-26 | Nouveaux derives de l'aprosamine |
| CH682681A CH646714A5 (de) | 1980-10-27 | 1981-10-26 | Aprosamin-derivate. |
| DE19813142401 DE3142401A1 (de) | 1980-10-27 | 1981-10-26 | Aprosamin-derivate und diese verbindungen enthaltende arzneimittel |
| GB8132391A GB2085882B (en) | 1980-10-27 | 1981-10-27 | Aprosamine derivatives |
| AU76871/81A AU553884B2 (en) | 1980-10-27 | 1981-10-27 | Beta-galactosidase inhibitor gt-2558 and its derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55150926A JPS5775994A (en) | 1980-10-27 | 1980-10-27 | Novel aprosamine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5775994A true JPS5775994A (en) | 1982-05-12 |
Family
ID=15507421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55150926A Pending JPS5775994A (en) | 1980-10-27 | 1980-10-27 | Novel aprosamine derivative |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4362866A (enExample) |
| JP (1) | JPS5775994A (enExample) |
| AU (1) | AU553884B2 (enExample) |
| BE (1) | BE890873A (enExample) |
| CH (1) | CH646714A5 (enExample) |
| DE (1) | DE3142401A1 (enExample) |
| FR (1) | FR2492828A1 (enExample) |
| GB (1) | GB2085882B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56138180A (en) * | 1980-03-28 | 1981-10-28 | Microbial Chem Res Found | Di-n6',o3-demethylistamycin a and its preparation |
| US4468512A (en) * | 1980-09-22 | 1984-08-28 | Eli Lilly And Company | 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides |
| US4468513A (en) * | 1980-09-22 | 1984-08-28 | Eli Lilly And Company | 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides |
| EP0130327B1 (de) * | 1983-05-21 | 1987-11-04 | Hoechst Aktiengesellschaft | Moenomycin A-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Antibiotika |
| JP2002535680A (ja) | 1999-01-27 | 2002-10-22 | ファルマシア・アンド・アップジョン・カンパニー | 延長因子ｐ活性モジュレーターのアッセイ方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3691279A (en) * | 1970-04-15 | 1972-09-12 | Lilly Co Eli | Antibiotic nebramycin and preparation thereof |
| US3853709A (en) * | 1970-10-26 | 1974-12-10 | Lilly Co Eli | Process for preparing nebramycin factors ii and vii |
| US3876767A (en) * | 1972-02-04 | 1975-04-08 | Lilly Co Eli | Treatment of swine dysentery with apramycin |
-
1980
- 1980-10-27 JP JP55150926A patent/JPS5775994A/ja active Pending
-
1981
- 1981-10-16 FR FR8119510A patent/FR2492828A1/fr active Granted
- 1981-10-22 US US06/313,971 patent/US4362866A/en not_active Expired - Fee Related
- 1981-10-26 CH CH682681A patent/CH646714A5/de not_active IP Right Cessation
- 1981-10-26 BE BE0/206352A patent/BE890873A/fr not_active IP Right Cessation
- 1981-10-26 DE DE19813142401 patent/DE3142401A1/de not_active Withdrawn
- 1981-10-27 GB GB8132391A patent/GB2085882B/en not_active Expired
- 1981-10-27 AU AU76871/81A patent/AU553884B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US4362866A (en) | 1982-12-07 |
| FR2492828B1 (enExample) | 1984-04-06 |
| DE3142401A1 (de) | 1982-06-24 |
| GB2085882A (en) | 1982-05-06 |
| GB2085882B (en) | 1985-01-30 |
| AU553884B2 (en) | 1986-07-31 |
| CH646714A5 (de) | 1984-12-14 |
| AU7687181A (en) | 1982-05-06 |
| BE890873A (fr) | 1982-02-15 |
| FR2492828A1 (fr) | 1982-04-30 |
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