JPS5592389A - Antibacterial agent - Google Patents

Antibacterial agent

Info

Publication number
JPS5592389A
JPS5592389A JP13249779A JP13249779A JPS5592389A JP S5592389 A JPS5592389 A JP S5592389A JP 13249779 A JP13249779 A JP 13249779A JP 13249779 A JP13249779 A JP 13249779A JP S5592389 A JPS5592389 A JP S5592389A
Authority
JP
Japan
Prior art keywords
salt
compound
acid
antibacterial agent
gram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13249779A
Other languages
Japanese (ja)
Inventor
Takayuki Naito
Jun Okumura
Hideaki Hoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BRISTOL MAYERS KENKYUSHO KK
Bristol Banyu Research Institute Ltd
Original Assignee
BRISTOL MAYERS KENKYUSHO KK
Bristol Banyu Research Institute Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BRISTOL MAYERS KENKYUSHO KK, Bristol Banyu Research Institute Ltd filed Critical BRISTOL MAYERS KENKYUSHO KK
Publication of JPS5592389A publication Critical patent/JPS5592389A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An acid of formula I having D-configuration at 6-position side chain, its pharmacologically permissible salt, or its easily hydrolyzable ester.
EXAMPLE: D-α-( 4-Ethyl-2, 3-dioxo-1-piperazinocarboxamido )-α-3, 4-dihydroxyphenylacetic acid.
USE: Antibacterial agent effective as a remedy for bacterial diseases caused by gram- negative and gram-positive bacteria.
PROCESS: The compound of formula I or its salt is prepared by reacting a compound II, its salt, or its ester, with an acylating compound III, e.g. an acid chloride, and if necessary, eliminating the protecting group from the product. The product thus obtained can be converted to a physiologically hydrolyzable ester.
COPYRIGHT: (C)1980,JPO&Japio
JP13249779A 1978-10-16 1979-10-16 Antibacterial agent Pending JPS5592389A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95190078A 1978-10-16 1978-10-16

Publications (1)

Publication Number Publication Date
JPS5592389A true JPS5592389A (en) 1980-07-12

Family

ID=25492297

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13249779A Pending JPS5592389A (en) 1978-10-16 1979-10-16 Antibacterial agent

Country Status (4)

Country Link
JP (1) JPS5592389A (en)
BE (1) BE879443A (en)
YU (1) YU222582A (en)
ZA (1) ZA795477B (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49116091A (en) * 1972-12-01 1974-11-06
JPS52122391A (en) * 1976-04-07 1977-10-14 Sangyo Kagaku Kenkyu Kyokai Novel penicillins
JPS52151187A (en) * 1976-06-08 1977-12-15 Toyama Chem Co Ltd Preparation of penicillins and cephalosporins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS49116091A (en) * 1972-12-01 1974-11-06
JPS52122391A (en) * 1976-04-07 1977-10-14 Sangyo Kagaku Kenkyu Kyokai Novel penicillins
JPS52151187A (en) * 1976-06-08 1977-12-15 Toyama Chem Co Ltd Preparation of penicillins and cephalosporins

Also Published As

Publication number Publication date
BE879443A (en) 1980-04-16
ZA795477B (en) 1981-03-25
YU222582A (en) 1985-03-20

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