JPS5653678A - Preparation of 1,10-phenanthroilnes - Google Patents
Preparation of 1,10-phenanthroilnesInfo
- Publication number
- JPS5653678A JPS5653678A JP8522280A JP8522280A JPS5653678A JP S5653678 A JPS5653678 A JP S5653678A JP 8522280 A JP8522280 A JP 8522280A JP 8522280 A JP8522280 A JP 8522280A JP S5653678 A JPS5653678 A JP S5653678A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- group
- phenanthroline
- dihydro
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 1, 4-Dihydro-1- carboxymethyl-4-oxo-1, 10-phenanthroline-3- carboxylic acid Chemical compound 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:1,4-Dihydro-4-oxo-1,10-phenanthroline-3-carboxylic acid of formula I (R is carboxylakyl).
EXAMPLE: 1, 4-Dihydro-1- carboxymethyl-4-oxo-1, 10-phenanthroline-3- carboxylic acid.
USE: Antibacterial agent having strong antibacterial activity to Gram-positive and Gram-negative bacteria.
PROCESS: The compound of formula I is prepared by reacting a compound of formula II with an alkylating agent of formula R'X (R' is a group which can be converted to R by hydrolysis; X is halogen) to introduce the R' group to the 1-position and at the same time, to hydrolyze the R' group to R group.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8522280A JPS5653678A (en) | 1980-06-25 | 1980-06-25 | Preparation of 1,10-phenanthroilnes |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8522280A JPS5653678A (en) | 1980-06-25 | 1980-06-25 | Preparation of 1,10-phenanthroilnes |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7861472A Division JPS5622870B2 (en) | 1972-08-05 | 1972-08-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5653678A true JPS5653678A (en) | 1981-05-13 |
JPS5640156B2 JPS5640156B2 (en) | 1981-09-18 |
Family
ID=13852533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8522280A Granted JPS5653678A (en) | 1980-06-25 | 1980-06-25 | Preparation of 1,10-phenanthroilnes |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5653678A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999021860A1 (en) * | 1997-10-24 | 1999-05-06 | Fibrogen, Inc. | Phenanthroline derivatives |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20120076A1 (en) | 2012-01-24 | 2013-07-25 | Pharmafilm Srl | THREE-DIMENSIONAL SCAFFOLD CONSTITUTED BY FIBROIN AND POLYETHYLENE GLUTEN FOR CELL CULTURE |
-
1980
- 1980-06-25 JP JP8522280A patent/JPS5653678A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999021860A1 (en) * | 1997-10-24 | 1999-05-06 | Fibrogen, Inc. | Phenanthroline derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS5640156B2 (en) | 1981-09-18 |
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