JPS57118544A - Novel peptide and its preparation - Google Patents

Novel peptide and its preparation

Info

Publication number
JPS57118544A
JPS57118544A JP56192506A JP19250681A JPS57118544A JP S57118544 A JPS57118544 A JP S57118544A JP 56192506 A JP56192506 A JP 56192506A JP 19250681 A JP19250681 A JP 19250681A JP S57118544 A JPS57118544 A JP S57118544A
Authority
JP
Japan
Prior art keywords
lower alkyl
formula
amino
compound
hydroxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56192506A
Other languages
Japanese (ja)
Other versions
JPH0325414B2 (en
Inventor
Shinji Hashimoto
Yoshihiko Kitaura
Osamu Nakaguchi
Keiji Henmi
Shuichi Takeno
Tatsu Okada
Satoshi Yonishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPS57118544A publication Critical patent/JPS57118544A/en
Publication of JPH0325414B2 publication Critical patent/JPH0325414B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:The peptide (salt) of formulaI[R1 is H or acyl; R2 is H or lower alkyl; R3 and R6 are (protected) carboxy, carbamoyl, etc.; R4 is H or (hydroxy)lower alkyl; R5 is H, carboxy(lower alkyl), etc.; R7 is H or amino- protecting group; n is 0 or 1; when R3 and R6 are not hydroxymethyl, one of R4 and R6 is hydroxy lower alkyl].
EXAMPLE: D-Lac-L-Ala-γ-D-(α-amino-α-hydroxymethyl)butyryl-(L)-mesoDAP-(L)- GlyOH of formula II.
USE: Remedy for infectious diseases caused by pathogenic microorganisms such as Gram-negative becteria, Gram-positive bacteria, fungi, etc.
PROCESS: The compound of formula V (Ra 1 is acyl; Ra 3 is protected carboxyl, etc.; Ra 7 is amino-protecting group) is prepared by reacting e.g. the compound of formula III with the compound of formula IV. The starting raw material of formula III wherein Ra 3 is R3 is novel substance.
COPYRIGHT: (C)1982,JPO&Japio
JP56192506A 1980-12-01 1981-11-30 Novel peptide and its preparation Granted JPS57118544A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8038509 1980-12-01

Publications (2)

Publication Number Publication Date
JPS57118544A true JPS57118544A (en) 1982-07-23
JPH0325414B2 JPH0325414B2 (en) 1991-04-05

Family

ID=10517687

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56192506A Granted JPS57118544A (en) 1980-12-01 1981-11-30 Novel peptide and its preparation

Country Status (1)

Country Link
JP (1) JPS57118544A (en)

Also Published As

Publication number Publication date
JPH0325414B2 (en) 1991-04-05

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