JPS57114556A - Novel peptide compound and its preparation - Google Patents

Novel peptide compound and its preparation

Info

Publication number
JPS57114556A
JPS57114556A JP56172658A JP17265881A JPS57114556A JP S57114556 A JPS57114556 A JP S57114556A JP 56172658 A JP56172658 A JP 56172658A JP 17265881 A JP17265881 A JP 17265881A JP S57114556 A JPS57114556 A JP S57114556A
Authority
JP
Japan
Prior art keywords
compound
formula
reaction
remedy
gram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56172658A
Other languages
Japanese (ja)
Other versions
JPH0325437B2 (en
Inventor
Yoshio Kuroda
Hideko Iguchi
Masanobu Kosaka
Hatsuo Aoki
Hiroshi Imanaka
Yoshihiko Kitaura
Osamu Nakaguchi
Keiji Henmi
Matsuhiko Araya
Shuichi Takeno
Tatsu Okada
Hirokazu Tanaka
Shinji Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US201241A external-priority patent/US4322341A/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPS57114556A publication Critical patent/JPS57114556A/en
Publication of JPH0325437B2 publication Critical patent/JPH0325437B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:The peptide compound of formulaI(R1 is n-octanoyl, stearoyl. n-docosanoyl, 2-acetoxypropionyl, etc.; R2 is H, methyl or benzyl; R3 is methoxy, carboxymethylamino, 1-methoxycarbonylethylamino, etc.; R4 is H, carboxy, methoxycarbonyl, carbazoyl, etc.; R5 is H, t-butoxycarbonyl, benzyloxycarbonyl, etc.; n is 0 or 1), or its salt.
EXAMPLE: The compound of formula II.
USE: Useful as a remedy for infectious diseases caused by pathogenic microorganisms, esp. Gram-negative bacteria, Gram-positive bacteria and fungi, and as a remedy for cancer of man and other animals.
PROCESS: The exemplified compound of formula II can be prepared, e.g. by the reaction for forming peptide bond, e.g. the reaction of the compound of formula III with the compound of formula IV. The compound of formulaIcan be prepared also by acylation reaction, methylation reaction, etc.
COPYRIGHT: (C)1982,JPO&Japio
JP56172658A 1980-10-27 1981-10-27 Novel peptide compound and its preparation Granted JPS57114556A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201241A US4322341A (en) 1980-05-13 1980-10-27 Peptide, process for preparation thereof and use thereof

Publications (2)

Publication Number Publication Date
JPS57114556A true JPS57114556A (en) 1982-07-16
JPH0325437B2 JPH0325437B2 (en) 1991-04-05

Family

ID=22745059

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56172658A Granted JPS57114556A (en) 1980-10-27 1981-10-27 Novel peptide compound and its preparation

Country Status (1)

Country Link
JP (1) JPS57114556A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59148745A (en) * 1983-02-08 1984-08-25 Fujisawa Pharmaceut Co Ltd Novel acylglutamyl lysine derivative
JP2002539186A (en) * 1999-03-17 2002-11-19 ノボ ノルディスク アクティーゼルスカブ Acylation method of peptide and novel acylating agent
JP2009029774A (en) * 2007-07-03 2009-02-12 Jsr Corp Method for producing amino acid-n-carboxy anhydride
JP2009029775A (en) * 2007-07-03 2009-02-12 Jsr Corp Method for producing amino acid-n-carboxy anhydride
JP2009227589A (en) * 2008-03-19 2009-10-08 Jsr Corp Method for producing amino acid-n-carboxy anhydride
US9562910B2 (en) 2002-09-25 2017-02-07 Novo Nordisk A/S Method for producing acylated peptides

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5576850A (en) * 1978-10-19 1980-06-10 Anvar Waterrsoluble compounds derived from extract of streptomyces stimulosus*their manufactures and immunologic adjuvant composition
JPS5585552A (en) * 1978-11-14 1980-06-27 Fujisawa Pharmaceut Co Ltd New lactyltetrapeptide
JPS5636440A (en) * 1979-06-29 1981-04-09 Rhone Poulenc Ind Tetrapeptide and pentapeptide* manufacture thereof and composition containing them
JPS5645447A (en) * 1979-06-29 1981-04-25 Rhone Poulenc Ind Tripeptides* their manufacture and composition containing them

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5576850A (en) * 1978-10-19 1980-06-10 Anvar Waterrsoluble compounds derived from extract of streptomyces stimulosus*their manufactures and immunologic adjuvant composition
JPS5585552A (en) * 1978-11-14 1980-06-27 Fujisawa Pharmaceut Co Ltd New lactyltetrapeptide
JPS5636440A (en) * 1979-06-29 1981-04-09 Rhone Poulenc Ind Tetrapeptide and pentapeptide* manufacture thereof and composition containing them
JPS5645447A (en) * 1979-06-29 1981-04-25 Rhone Poulenc Ind Tripeptides* their manufacture and composition containing them

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59148745A (en) * 1983-02-08 1984-08-25 Fujisawa Pharmaceut Co Ltd Novel acylglutamyl lysine derivative
JP2002539186A (en) * 1999-03-17 2002-11-19 ノボ ノルディスク アクティーゼルスカブ Acylation method of peptide and novel acylating agent
JP4949557B2 (en) * 1999-03-17 2012-06-13 ノヴォ ノルディスク アー／エス Peptide acylation method and novel acylating agent
US9562910B2 (en) 2002-09-25 2017-02-07 Novo Nordisk A/S Method for producing acylated peptides
JP2009029774A (en) * 2007-07-03 2009-02-12 Jsr Corp Method for producing amino acid-n-carboxy anhydride
JP2009029775A (en) * 2007-07-03 2009-02-12 Jsr Corp Method for producing amino acid-n-carboxy anhydride
JP2009227589A (en) * 2008-03-19 2009-10-08 Jsr Corp Method for producing amino acid-n-carboxy anhydride

Also Published As

Publication number Publication date
JPH0325437B2 (en) 1991-04-05

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