JPS5775942A - Production of 3,4,5-trialkoxybenzylalcohol derivative - Google Patents
Production of 3,4,5-trialkoxybenzylalcohol derivativeInfo
- Publication number
- JPS5775942A JPS5775942A JP15263180A JP15263180A JPS5775942A JP S5775942 A JPS5775942 A JP S5775942A JP 15263180 A JP15263180 A JP 15263180A JP 15263180 A JP15263180 A JP 15263180A JP S5775942 A JPS5775942 A JP S5775942A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- compound
- proton
- methanol
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: A readily available raw material is used to effect the reaction under mild conditions to produce the titled compound which is used as an intermediate of 3,4,5- trimethoxybenzaldehyde, a starting material of medicines such as trimethoprim in high yield.
CONSTITUTION: The compound of formulaI(R is methyl, ethyl), which is readily obtained by electrolysis of 3,4,5-trialkoxytoluene in high yield, is heated in a solvent such as water, methanol or acetic acid in the presence of a proton acid or Lewis acid at 20W50°C for 3W5hr to give the objective compound of formula II (R2 is H, methyl, ethyl, acetyl). The products vary depending on the combination of the solvent and the acid used; the combination of methanol, ethanol with a proton acid gives benzyl alkyl ether; water and a Lewis acid, benzyl alcohol, and acetic acid and a proton acid, benzyl acetate in high yields.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15263180A JPS6050174B2 (en) | 1980-10-29 | 1980-10-29 | Method for producing 3,4,5-trialkoxybenzyl alcohol derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15263180A JPS6050174B2 (en) | 1980-10-29 | 1980-10-29 | Method for producing 3,4,5-trialkoxybenzyl alcohol derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5775942A true JPS5775942A (en) | 1982-05-12 |
JPS6050174B2 JPS6050174B2 (en) | 1985-11-07 |
Family
ID=15544601
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15263180A Expired JPS6050174B2 (en) | 1980-10-29 | 1980-10-29 | Method for producing 3,4,5-trialkoxybenzyl alcohol derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6050174B2 (en) |
-
1980
- 1980-10-29 JP JP15263180A patent/JPS6050174B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS6050174B2 (en) | 1985-11-07 |
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