JPS5756487A - Novel 7alpha-methoxycephalosporin and its preparation - Google Patents

Novel 7alpha-methoxycephalosporin and its preparation

Info

Publication number
JPS5756487A
JPS5756487A JP56116188A JP11618881A JPS5756487A JP S5756487 A JPS5756487 A JP S5756487A JP 56116188 A JP56116188 A JP 56116188A JP 11618881 A JP11618881 A JP 11618881A JP S5756487 A JPS5756487 A JP S5756487A
Authority
JP
Japan
Prior art keywords
compound
preparation
formulai
reaction
methoxycephalosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56116188A
Other languages
Japanese (ja)
Other versions
JPS6019915B2 (en
Inventor
Isamu Saikawa
Shuntaro Takano
Hiroyuki Imaizumi
Isamu Takakura
Yuichi Ochiai
Takashi Yasuda
Hideo Taki
Masaru Tai
Hiroshi Kodama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to JP56116188A priority Critical patent/JPS6019915B2/en
Publication of JPS5756487A publication Critical patent/JPS5756487A/en
Publication of JPS6019915B2 publication Critical patent/JPS6019915B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A compound of formulaI(R1 is H, carboxyl-protecting group, salt-forming cation; R2 is acyloxy, carbamoyloxy; A is alkyl; X is H, hydroxyl).
EXAMPLE: 7β-[D(-)-α-(4-ethyl-2,3-dioxo-1-piperazinylcarbonylamino) phenylacetamide]-7α-methoxy-3-acetoxymethyl-Δ3-cephem-4-carboxylic acid.
USE: Antibiotic: it shows activity against gram-positive and -negative bacteria and has a wide range of antibacterial spectrum. Further, it is stable to cephalosporinase.
PREPARATION: The reaction of a compound of formula II (R8 is organic silyl, organic phosphorus) with a reactive derivative of a compound of formula III at the carboxyl groups is carried out in an inert solvent at -40W50°C to give the compound of formulaI. The reaction may be effected in the presence of a base such as alkali hydroxide or trimethylamine, too.
COPYRIGHT: (C)1982,JPO&Japio
JP56116188A 1981-07-24 1981-07-24 Novel 7α-methoxycephalosporins and their production method Expired JPS6019915B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56116188A JPS6019915B2 (en) 1981-07-24 1981-07-24 Novel 7α-methoxycephalosporins and their production method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56116188A JPS6019915B2 (en) 1981-07-24 1981-07-24 Novel 7α-methoxycephalosporins and their production method

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP51006117A Division JPS6026800B2 (en) 1976-01-22 1976-01-22 Novel 7α-methoxycephalosporins and their production method

Publications (2)

Publication Number Publication Date
JPS5756487A true JPS5756487A (en) 1982-04-05
JPS6019915B2 JPS6019915B2 (en) 1985-05-18

Family

ID=14680998

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56116188A Expired JPS6019915B2 (en) 1981-07-24 1981-07-24 Novel 7α-methoxycephalosporins and their production method

Country Status (1)

Country Link
JP (1) JPS6019915B2 (en)

Also Published As

Publication number Publication date
JPS6019915B2 (en) 1985-05-18

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