JPS5732293A - Carcinostatic substance tf-132b, its preparation, and carcinostatic agent containing the same - Google Patents
Carcinostatic substance tf-132b, its preparation, and carcinostatic agent containing the sameInfo
- Publication number
- JPS5732293A JPS5732293A JP10812080A JP10812080A JPS5732293A JP S5732293 A JPS5732293 A JP S5732293A JP 10812080 A JP10812080 A JP 10812080A JP 10812080 A JP10812080 A JP 10812080A JP S5732293 A JPS5732293 A JP S5732293A
- Authority
- JP
- Japan
- Prior art keywords
- carcinostatic
- reaction
- precipitate
- water
- cultured
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:Carcinostatic substance TF-132b having the following characteristics: appearance, light grey to pale brown powder; melting pont, no definite melting point, begins to decompose at 110°C, and vigorously decomposes at ≥200°C; elemental analysis, C 35.3W39.5%, H 4.5W5.6%, N 2.8W5.4%; solubility, soluble in water, insoluble in methanol, acetone, chloroform, diethyl ether, etc.; color reaction, positive to Molish reaction, phenol-sulfuric acid reaction, etc., negative to ninhydrin reaction.
USE: Carcinostatic agent. It can inhibit the proliferation of the cells of Ehrlich ascites carcinoma of mouse, Ehrlich nodular carcinoma, and sarcoma 180 cancer, and has immuno-activating activity.
PROCESS: TF-132b-producing bacteria belonging to Fusobacterium genus, e.g. Fusobacterium nucleatum TF-031 (FERM-P No.5077), is cultured, and the cultured liquid is mixed with a hydrophilic organic solvent to obtain the precipitate. The objective TF-132b is separated from the water-soluble component of the precipitate.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10812080A JPS5732293A (en) | 1980-08-06 | 1980-08-06 | Carcinostatic substance tf-132b, its preparation, and carcinostatic agent containing the same |
DE19803031152 DE3031152A1 (en) | 1979-08-24 | 1980-08-18 | CARCINOSTATIC SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND MEDIUM WITH A CONTENT THEREOF |
GB8027026A GB2059969B (en) | 1979-08-24 | 1980-08-19 | Fusobacterium culture extracts |
CA000358667A CA1174618A (en) | 1979-08-24 | 1980-08-20 | Substances having carcinostatic and immunostimulating activity, process for preparing the same and carcinostatic agent containing the same |
AU61646/80A AU529076B2 (en) | 1979-08-24 | 1980-08-21 | Carcinostatic agents |
AT0426480A AT375674B (en) | 1979-08-24 | 1980-08-21 | METHOD FOR PRODUCING NEW CARCINOSTATIC SUBSTANCES |
US06/180,040 US4744985A (en) | 1979-08-24 | 1980-08-21 | Novel substances having carcinostatic and immunostimulating activity, process for preparing the same and carcinostatic agent containing the same |
FI802641A FI68080C (en) | 1979-08-24 | 1980-08-21 | FOER FARING FOR CARCINOSTATICS AND IMMUNOSISCULATION OF SUBSTANCES |
BE0/201815A BE884864A (en) | 1979-08-24 | 1980-08-21 | NOVEL SUBSTANCES PRODUCED BY FUSOBACTERIUM BACTERIA, PREPARATION METHOD THEREOF AND THERAPEUTIC APPLICATION THEREOF |
CH6297/80A CH648042A5 (en) | 1979-08-24 | 1980-08-21 | CARCINOSTATIC SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND MEDIUM WITH A CONTENT THEREOF. |
NO802499A NO155697C (en) | 1979-08-24 | 1980-08-22 | PROCEDURE FOR THE PREPARATION OF PHYSIOLOGICALLY ACTIVE COMPOUNDS. |
NZ194744A NZ194744A (en) | 1979-08-24 | 1980-08-22 | Preparation of carcinostatic and immunostimulating tf-substances from fusobacterium |
FR8018396A FR2463619A1 (en) | 1979-08-24 | 1980-08-22 | NEW SUBSTANCES PRODUCED BY BACTERIA OF THE GENUS FUSOBACTERIUM, PROCESS FOR PREPARING THEM AND THEIR USE IN THERAPEUTICS |
IT49541/80A IT1181595B (en) | 1979-08-24 | 1980-08-22 | CARCINOSTATIC SUBSTANCES AND IMMUNE STIMULANTS PROCEDURE TO PREPARE THEM AND CARCINOSTATIC AGENT CONTAINING THEM |
DK361680A DK151639C (en) | 1979-08-24 | 1980-08-22 | PROCEDURE FOR PREPARING TF-100 OR FRACTIONS WITH CARCINOSTATIC AND IMMUNOSTIMULATING ACTIVITY |
SE8005921A SE446406B (en) | 1979-08-24 | 1980-08-22 | NEW COMPOUNDS WITH CARCINOSTATIC AND IMMUNOSTIMULATING EFFECTS PRODUCED BY CULTIVATION OF FUSOBACTERIUM NUCLEATUM TF-031 (FERM 5077, ATCC 31647), PROCEDURE FOR THE PRODUCTION OF SAME AND CARCINOSTATIC |
NL8004759A NL8004759A (en) | 1979-08-24 | 1980-08-22 | NEW SUBSTANCES WITH CARCINOSTATIC AND IMMUNO-STIMULATING EFFECTS, METHOD FOR THE PREPARATION THEREOF AND CARCINOSTATIC PREPARATIONS CONTAINING THESE SUBSTANCES. |
PT71730A PT71730A (en) | 1979-08-24 | 1980-08-22 | Process for preparing novel substances having carcinostatic immunostimulating activity and a carcinostatic agent containing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10812080A JPS5732293A (en) | 1980-08-06 | 1980-08-06 | Carcinostatic substance tf-132b, its preparation, and carcinostatic agent containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5732293A true JPS5732293A (en) | 1982-02-20 |
JPS6261036B2 JPS6261036B2 (en) | 1987-12-18 |
Family
ID=14476424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10812080A Granted JPS5732293A (en) | 1979-08-24 | 1980-08-06 | Carcinostatic substance tf-132b, its preparation, and carcinostatic agent containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5732293A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59175850U (en) * | 1983-05-06 | 1984-11-24 | 三菱重工業株式会社 | Slag discharge device for coal-fired MHD combustor |
JPS6158538U (en) * | 1984-09-17 | 1986-04-19 |
-
1980
- 1980-08-06 JP JP10812080A patent/JPS5732293A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59175850U (en) * | 1983-05-06 | 1984-11-24 | 三菱重工業株式会社 | Slag discharge device for coal-fired MHD combustor |
JPH0120519Y2 (en) * | 1983-05-06 | 1989-06-20 | ||
JPS6158538U (en) * | 1984-09-17 | 1986-04-19 | ||
JPH0318804Y2 (en) * | 1984-09-17 | 1991-04-22 |
Also Published As
Publication number | Publication date |
---|---|
JPS6261036B2 (en) | 1987-12-18 |
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