JPS5630996A - Carcinostatic substance tf-110, its preparation, and carcinostatic comprizing it - Google Patents
Carcinostatic substance tf-110, its preparation, and carcinostatic comprizing itInfo
- Publication number
- JPS5630996A JPS5630996A JP10781779A JP10781779A JPS5630996A JP S5630996 A JPS5630996 A JP S5630996A JP 10781779 A JP10781779 A JP 10781779A JP 10781779 A JP10781779 A JP 10781779A JP S5630996 A JPS5630996 A JP S5630996A
- Authority
- JP
- Japan
- Prior art keywords
- carcinostatic
- action
- substance
- carcinoma
- ehrlich
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
NEW MATERIAL:A carcinostatic substance TF-110 having the following properties, obtained from a culture solution which is prepared by cultivating a bacterium belonging to the genus Fusobacterium, producing carcinostatic substance TF-110. White grey to light brown powder. Capable of preventing growth of Ehrilich ascites carcinoma and Ehrlich tuberous carcinoma of mouce, and having immunizing action. Water-soluble, neutral, insoluble in methanol, benzene, etc. Not exhibiting the clear melting point, begins to decompose at 110°C and decomposes extremely at not lower than 200°C. Positive in Molisch reaction and negative in ninhydrin reaction. C 35.9W41wt%, H 4.5W5.2wt%, N 4.2W5.2wt%, etc.
USE: A carcinostatic. Having preventing action on colony formation of carcinomatous cell, immunizing action, inhibition of Ehrlich ascites carcinoma, and extreme effect especially on solid cancer.
PROCESS: For example, Fusobacterium nucleatum TF-031 (FERM-5077) is allowed to stand for cultivation preferably under anaerobic conditions at 30W40°C for 1W5 days.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10781779A JPS5630996A (en) | 1979-08-24 | 1979-08-24 | Carcinostatic substance tf-110, its preparation, and carcinostatic comprizing it |
DE19803031152 DE3031152A1 (en) | 1979-08-24 | 1980-08-18 | CARCINOSTATIC SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND MEDIUM WITH A CONTENT THEREOF |
GB8027026A GB2059969B (en) | 1979-08-24 | 1980-08-19 | Fusobacterium culture extracts |
CA000358667A CA1174618A (en) | 1979-08-24 | 1980-08-20 | Substances having carcinostatic and immunostimulating activity, process for preparing the same and carcinostatic agent containing the same |
FI802641A FI68080C (en) | 1979-08-24 | 1980-08-21 | FOER FARING FOR CARCINOSTATICS AND IMMUNOSISCULATION OF SUBSTANCES |
AU61646/80A AU529076B2 (en) | 1979-08-24 | 1980-08-21 | Carcinostatic agents |
CH6297/80A CH648042A5 (en) | 1979-08-24 | 1980-08-21 | CARCINOSTATIC SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND MEDIUM WITH A CONTENT THEREOF. |
US06/180,040 US4744985A (en) | 1979-08-24 | 1980-08-21 | Novel substances having carcinostatic and immunostimulating activity, process for preparing the same and carcinostatic agent containing the same |
AT0426480A AT375674B (en) | 1979-08-24 | 1980-08-21 | METHOD FOR PRODUCING NEW CARCINOSTATIC SUBSTANCES |
BE0/201815A BE884864A (en) | 1979-08-24 | 1980-08-21 | NOVEL SUBSTANCES PRODUCED BY FUSOBACTERIUM BACTERIA, PREPARATION METHOD THEREOF AND THERAPEUTIC APPLICATION THEREOF |
IT49541/80A IT1181595B (en) | 1979-08-24 | 1980-08-22 | CARCINOSTATIC SUBSTANCES AND IMMUNE STIMULANTS PROCEDURE TO PREPARE THEM AND CARCINOSTATIC AGENT CONTAINING THEM |
NO802499A NO155697C (en) | 1979-08-24 | 1980-08-22 | PROCEDURE FOR THE PREPARATION OF PHYSIOLOGICALLY ACTIVE COMPOUNDS. |
SE8005921A SE446406B (en) | 1979-08-24 | 1980-08-22 | NEW COMPOUNDS WITH CARCINOSTATIC AND IMMUNOSTIMULATING EFFECTS PRODUCED BY CULTIVATION OF FUSOBACTERIUM NUCLEATUM TF-031 (FERM 5077, ATCC 31647), PROCEDURE FOR THE PRODUCTION OF SAME AND CARCINOSTATIC |
NZ194744A NZ194744A (en) | 1979-08-24 | 1980-08-22 | Preparation of carcinostatic and immunostimulating tf-substances from fusobacterium |
DK361680A DK151639C (en) | 1979-08-24 | 1980-08-22 | PROCEDURE FOR PREPARING TF-100 OR FRACTIONS WITH CARCINOSTATIC AND IMMUNOSTIMULATING ACTIVITY |
NL8004759A NL8004759A (en) | 1979-08-24 | 1980-08-22 | NEW SUBSTANCES WITH CARCINOSTATIC AND IMMUNO-STIMULATING EFFECTS, METHOD FOR THE PREPARATION THEREOF AND CARCINOSTATIC PREPARATIONS CONTAINING THESE SUBSTANCES. |
FR8018396A FR2463619A1 (en) | 1979-08-24 | 1980-08-22 | NEW SUBSTANCES PRODUCED BY BACTERIA OF THE GENUS FUSOBACTERIUM, PROCESS FOR PREPARING THEM AND THEIR USE IN THERAPEUTICS |
DD22346380A DD153999A5 (en) | 1979-08-24 | 1980-08-22 | PROCESS FOR THE PRODUCTION OF SUBSTANCES WITH CARCINOSTATIC AND IMMUNOSTIMULATING EFFECT |
PT71730A PT71730A (en) | 1979-08-24 | 1980-08-22 | Process for preparing novel substances having carcinostatic immunostimulating activity and a carcinostatic agent containing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10781779A JPS5630996A (en) | 1979-08-24 | 1979-08-24 | Carcinostatic substance tf-110, its preparation, and carcinostatic comprizing it |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5630996A true JPS5630996A (en) | 1981-03-28 |
JPS627917B2 JPS627917B2 (en) | 1987-02-19 |
Family
ID=14468780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10781779A Granted JPS5630996A (en) | 1979-08-24 | 1979-08-24 | Carcinostatic substance tf-110, its preparation, and carcinostatic comprizing it |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5630996A (en) |
-
1979
- 1979-08-24 JP JP10781779A patent/JPS5630996A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS627917B2 (en) | 1987-02-19 |
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