JPS5645496A - Carcinostatic substance, tf-130, its preparation and carcinostatic preparation containing the same - Google Patents
Carcinostatic substance, tf-130, its preparation and carcinostatic preparation containing the sameInfo
- Publication number
- JPS5645496A JPS5645496A JP10781979A JP10781979A JPS5645496A JP S5645496 A JPS5645496 A JP S5645496A JP 10781979 A JP10781979 A JP 10781979A JP 10781979 A JP10781979 A JP 10781979A JP S5645496 A JPS5645496 A JP S5645496A
- Authority
- JP
- Japan
- Prior art keywords
- carcinostatic
- substance
- tumor
- preparation
- test
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
NEW MATERIAL:A carcinostatic substance, TF-130, which is obtained from the culture mixture resulting from the cultivation of a bacterium that belongs to Fusobacterium and can produce the carcinostatic substance, TF-130, and has folowing properties: a whity-grey to light brown powder; inhibiting the growth of cells of Ehrlich ascites-tumor, Ehrlich tuber tumor and sarcoma-180 tumor and having immunization activity; water-soluble and neutral, insoluble in methanol, benzene, etc.; showing now definite melting point and starting decomposition from about 110°C; positive in the Molisch's test, phenol-sulfuric acid test and other tests, while negative in the ninhydrin test; C 27.5W39.8%, H 3.2W5.7%, N 2.8W6.3%; the saccharide content is 19W64% (calculated as glucose) and the protein content is 6W 28% (calculated as cow serum albumin).
USE: Carcinostatic.
PREPARATION: For example, the substance is obtained by the cultivation of the mold of Fusobacterium nucleatum TF-031 (FERM-5077).
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10781979A JPS5645496A (en) | 1979-08-24 | 1979-08-24 | Carcinostatic substance, tf-130, its preparation and carcinostatic preparation containing the same |
DE19803031152 DE3031152A1 (en) | 1979-08-24 | 1980-08-18 | CARCINOSTATIC SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND MEDIUM WITH A CONTENT THEREOF |
GB8027026A GB2059969B (en) | 1979-08-24 | 1980-08-19 | Fusobacterium culture extracts |
CA000358667A CA1174618A (en) | 1979-08-24 | 1980-08-20 | Substances having carcinostatic and immunostimulating activity, process for preparing the same and carcinostatic agent containing the same |
FI802641A FI68080C (en) | 1979-08-24 | 1980-08-21 | FOER FARING FOR CARCINOSTATICS AND IMMUNOSISCULATION OF SUBSTANCES |
BE0/201815A BE884864A (en) | 1979-08-24 | 1980-08-21 | NOVEL SUBSTANCES PRODUCED BY FUSOBACTERIUM BACTERIA, PREPARATION METHOD THEREOF AND THERAPEUTIC APPLICATION THEREOF |
CH6297/80A CH648042A5 (en) | 1979-08-24 | 1980-08-21 | CARCINOSTATIC SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND MEDIUM WITH A CONTENT THEREOF. |
AT0426480A AT375674B (en) | 1979-08-24 | 1980-08-21 | METHOD FOR PRODUCING NEW CARCINOSTATIC SUBSTANCES |
US06/180,040 US4744985A (en) | 1979-08-24 | 1980-08-21 | Novel substances having carcinostatic and immunostimulating activity, process for preparing the same and carcinostatic agent containing the same |
AU61646/80A AU529076B2 (en) | 1979-08-24 | 1980-08-21 | Carcinostatic agents |
NO802499A NO155697C (en) | 1979-08-24 | 1980-08-22 | PROCEDURE FOR THE PREPARATION OF PHYSIOLOGICALLY ACTIVE COMPOUNDS. |
DD22346380A DD153999A5 (en) | 1979-08-24 | 1980-08-22 | PROCESS FOR THE PRODUCTION OF SUBSTANCES WITH CARCINOSTATIC AND IMMUNOSTIMULATING EFFECT |
IT49541/80A IT1181595B (en) | 1979-08-24 | 1980-08-22 | CARCINOSTATIC SUBSTANCES AND IMMUNE STIMULANTS PROCEDURE TO PREPARE THEM AND CARCINOSTATIC AGENT CONTAINING THEM |
PT71730A PT71730A (en) | 1979-08-24 | 1980-08-22 | Process for preparing novel substances having carcinostatic immunostimulating activity and a carcinostatic agent containing the same |
NZ194744A NZ194744A (en) | 1979-08-24 | 1980-08-22 | Preparation of carcinostatic and immunostimulating tf-substances from fusobacterium |
DK361680A DK151639C (en) | 1979-08-24 | 1980-08-22 | PROCEDURE FOR PREPARING TF-100 OR FRACTIONS WITH CARCINOSTATIC AND IMMUNOSTIMULATING ACTIVITY |
SE8005921A SE446406B (en) | 1979-08-24 | 1980-08-22 | NEW COMPOUNDS WITH CARCINOSTATIC AND IMMUNOSTIMULATING EFFECTS PRODUCED BY CULTIVATION OF FUSOBACTERIUM NUCLEATUM TF-031 (FERM 5077, ATCC 31647), PROCEDURE FOR THE PRODUCTION OF SAME AND CARCINOSTATIC |
NL8004759A NL8004759A (en) | 1979-08-24 | 1980-08-22 | NEW SUBSTANCES WITH CARCINOSTATIC AND IMMUNO-STIMULATING EFFECTS, METHOD FOR THE PREPARATION THEREOF AND CARCINOSTATIC PREPARATIONS CONTAINING THESE SUBSTANCES. |
FR8018396A FR2463619A1 (en) | 1979-08-24 | 1980-08-22 | NEW SUBSTANCES PRODUCED BY BACTERIA OF THE GENUS FUSOBACTERIUM, PROCESS FOR PREPARING THEM AND THEIR USE IN THERAPEUTICS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10781979A JPS5645496A (en) | 1979-08-24 | 1979-08-24 | Carcinostatic substance, tf-130, its preparation and carcinostatic preparation containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5645496A true JPS5645496A (en) | 1981-04-25 |
JPS627919B2 JPS627919B2 (en) | 1987-02-19 |
Family
ID=14468832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10781979A Granted JPS5645496A (en) | 1979-08-24 | 1979-08-24 | Carcinostatic substance, tf-130, its preparation and carcinostatic preparation containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5645496A (en) |
-
1979
- 1979-08-24 JP JP10781979A patent/JPS5645496A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS627919B2 (en) | 1987-02-19 |
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