JPS5645496A - Carcinostatic substance, tf-130, its preparation and carcinostatic preparation containing the same - Google Patents

Carcinostatic substance, tf-130, its preparation and carcinostatic preparation containing the same

Info

Publication number
JPS5645496A
JPS5645496A JP10781979A JP10781979A JPS5645496A JP S5645496 A JPS5645496 A JP S5645496A JP 10781979 A JP10781979 A JP 10781979A JP 10781979 A JP10781979 A JP 10781979A JP S5645496 A JPS5645496 A JP S5645496A
Authority
JP
Japan
Prior art keywords
carcinostatic
substance
tumor
preparation
test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10781979A
Other languages
Japanese (ja)
Other versions
JPS627919B2 (en
Inventor
Kenzo Tamai
Isamu Saikawa
Takashi Yasuda
Shohachi Murakami
Toyoo Maeda
Hisatsugu Tsuda
Hiroshi Sakai
Masatoshi Sugita
Yoshiko Yamamoto
Takashi Minami
Takako Hori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to JP10781979A priority Critical patent/JPS5645496A/en
Priority to DE19803031152 priority patent/DE3031152A1/en
Priority to GB8027026A priority patent/GB2059969B/en
Priority to CA000358667A priority patent/CA1174618A/en
Priority to FI802641A priority patent/FI68080C/en
Priority to BE0/201815A priority patent/BE884864A/en
Priority to CH6297/80A priority patent/CH648042A5/en
Priority to AT0426480A priority patent/AT375674B/en
Priority to US06/180,040 priority patent/US4744985A/en
Priority to AU61646/80A priority patent/AU529076B2/en
Priority to NO802499A priority patent/NO155697C/en
Priority to DD22346380A priority patent/DD153999A5/en
Priority to IT49541/80A priority patent/IT1181595B/en
Priority to PT71730A priority patent/PT71730A/en
Priority to NZ194744A priority patent/NZ194744A/en
Priority to DK361680A priority patent/DK151639C/en
Priority to SE8005921A priority patent/SE446406B/en
Priority to NL8004759A priority patent/NL8004759A/en
Priority to FR8018396A priority patent/FR2463619A1/en
Publication of JPS5645496A publication Critical patent/JPS5645496A/en
Publication of JPS627919B2 publication Critical patent/JPS627919B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

NEW MATERIAL:A carcinostatic substance, TF-130, which is obtained from the culture mixture resulting from the cultivation of a bacterium that belongs to Fusobacterium and can produce the carcinostatic substance, TF-130, and has folowing properties: a whity-grey to light brown powder; inhibiting the growth of cells of Ehrlich ascites-tumor, Ehrlich tuber tumor and sarcoma-180 tumor and having immunization activity; water-soluble and neutral, insoluble in methanol, benzene, etc.; showing now definite melting point and starting decomposition from about 110°C; positive in the Molisch's test, phenol-sulfuric acid test and other tests, while negative in the ninhydrin test; C 27.5W39.8%, H 3.2W5.7%, N 2.8W6.3%; the saccharide content is 19W64% (calculated as glucose) and the protein content is 6W 28% (calculated as cow serum albumin).
USE: Carcinostatic.
PREPARATION: For example, the substance is obtained by the cultivation of the mold of Fusobacterium nucleatum TF-031 (FERM-5077).
COPYRIGHT: (C)1981,JPO&Japio
JP10781979A 1979-08-24 1979-08-24 Carcinostatic substance, tf-130, its preparation and carcinostatic preparation containing the same Granted JPS5645496A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
JP10781979A JPS5645496A (en) 1979-08-24 1979-08-24 Carcinostatic substance, tf-130, its preparation and carcinostatic preparation containing the same
DE19803031152 DE3031152A1 (en) 1979-08-24 1980-08-18 CARCINOSTATIC SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND MEDIUM WITH A CONTENT THEREOF
GB8027026A GB2059969B (en) 1979-08-24 1980-08-19 Fusobacterium culture extracts
CA000358667A CA1174618A (en) 1979-08-24 1980-08-20 Substances having carcinostatic and immunostimulating activity, process for preparing the same and carcinostatic agent containing the same
FI802641A FI68080C (en) 1979-08-24 1980-08-21 FOER FARING FOR CARCINOSTATICS AND IMMUNOSISCULATION OF SUBSTANCES
BE0/201815A BE884864A (en) 1979-08-24 1980-08-21 NOVEL SUBSTANCES PRODUCED BY FUSOBACTERIUM BACTERIA, PREPARATION METHOD THEREOF AND THERAPEUTIC APPLICATION THEREOF
CH6297/80A CH648042A5 (en) 1979-08-24 1980-08-21 CARCINOSTATIC SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND MEDIUM WITH A CONTENT THEREOF.
AT0426480A AT375674B (en) 1979-08-24 1980-08-21 METHOD FOR PRODUCING NEW CARCINOSTATIC SUBSTANCES
US06/180,040 US4744985A (en) 1979-08-24 1980-08-21 Novel substances having carcinostatic and immunostimulating activity, process for preparing the same and carcinostatic agent containing the same
AU61646/80A AU529076B2 (en) 1979-08-24 1980-08-21 Carcinostatic agents
NO802499A NO155697C (en) 1979-08-24 1980-08-22 PROCEDURE FOR THE PREPARATION OF PHYSIOLOGICALLY ACTIVE COMPOUNDS.
DD22346380A DD153999A5 (en) 1979-08-24 1980-08-22 PROCESS FOR THE PRODUCTION OF SUBSTANCES WITH CARCINOSTATIC AND IMMUNOSTIMULATING EFFECT
IT49541/80A IT1181595B (en) 1979-08-24 1980-08-22 CARCINOSTATIC SUBSTANCES AND IMMUNE STIMULANTS PROCEDURE TO PREPARE THEM AND CARCINOSTATIC AGENT CONTAINING THEM
PT71730A PT71730A (en) 1979-08-24 1980-08-22 Process for preparing novel substances having carcinostatic immunostimulating activity and a carcinostatic agent containing the same
NZ194744A NZ194744A (en) 1979-08-24 1980-08-22 Preparation of carcinostatic and immunostimulating tf-substances from fusobacterium
DK361680A DK151639C (en) 1979-08-24 1980-08-22 PROCEDURE FOR PREPARING TF-100 OR FRACTIONS WITH CARCINOSTATIC AND IMMUNOSTIMULATING ACTIVITY
SE8005921A SE446406B (en) 1979-08-24 1980-08-22 NEW COMPOUNDS WITH CARCINOSTATIC AND IMMUNOSTIMULATING EFFECTS PRODUCED BY CULTIVATION OF FUSOBACTERIUM NUCLEATUM TF-031 (FERM 5077, ATCC 31647), PROCEDURE FOR THE PRODUCTION OF SAME AND CARCINOSTATIC
NL8004759A NL8004759A (en) 1979-08-24 1980-08-22 NEW SUBSTANCES WITH CARCINOSTATIC AND IMMUNO-STIMULATING EFFECTS, METHOD FOR THE PREPARATION THEREOF AND CARCINOSTATIC PREPARATIONS CONTAINING THESE SUBSTANCES.
FR8018396A FR2463619A1 (en) 1979-08-24 1980-08-22 NEW SUBSTANCES PRODUCED BY BACTERIA OF THE GENUS FUSOBACTERIUM, PROCESS FOR PREPARING THEM AND THEIR USE IN THERAPEUTICS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10781979A JPS5645496A (en) 1979-08-24 1979-08-24 Carcinostatic substance, tf-130, its preparation and carcinostatic preparation containing the same

Publications (2)

Publication Number Publication Date
JPS5645496A true JPS5645496A (en) 1981-04-25
JPS627919B2 JPS627919B2 (en) 1987-02-19

Family

ID=14468832

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10781979A Granted JPS5645496A (en) 1979-08-24 1979-08-24 Carcinostatic substance, tf-130, its preparation and carcinostatic preparation containing the same

Country Status (1)

Country Link
JP (1) JPS5645496A (en)

Also Published As

Publication number Publication date
JPS627919B2 (en) 1987-02-19

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