JPS5728056A - Dihydropyridazinone derivative - Google Patents
Dihydropyridazinone derivativeInfo
- Publication number
- JPS5728056A JPS5728056A JP10536380A JP10536380A JPS5728056A JP S5728056 A JPS5728056 A JP S5728056A JP 10536380 A JP10536380 A JP 10536380A JP 10536380 A JP10536380 A JP 10536380A JP S5728056 A JPS5728056 A JP S5728056A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- lower alkyl
- reacted
- dihydropyridazinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A dihydropyridazinone derivative of formula I (R1, R2 and R3 are H, halogen, lower alkyl or lower alkyloxy; R4 and R5 are H or lower alkyl; R6 is lower alkyl; m is an integer 1W5).
EXAMPLE: N-Cyano-N'-[ 4-( 4,5-dihydro-6-phenyl-3-oxo-2-pyridazinyl )butyl ]-N"- methylguanidine.
USE: Useful as a remedy and a preventing agent against peptic ulcers, e.g. gastric hyperacidity, gastric ulcer or duodenal ulcer, and having great prolonged action, low toxicity and improved chemical resistance.
PROCESS: An amine derivative of formula II is reacted with dimethyl cyanodithioimidocarbonate in the absence or presence of an inert solvent, e.g. ethanol, at room temperature or under cooling to give an isothiourea derivative of formula III, which is then reacted with an amide derivative of formula IV under heating to afford the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10536380A JPS5728056A (en) | 1980-07-29 | 1980-07-29 | Dihydropyridazinone derivative |
EP19800304409 EP0030835B1 (en) | 1979-12-05 | 1980-12-05 | Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them |
DE8080304409T DE3063196D1 (en) | 1979-12-05 | 1980-12-05 | Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10536380A JPS5728056A (en) | 1980-07-29 | 1980-07-29 | Dihydropyridazinone derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5728056A true JPS5728056A (en) | 1982-02-15 |
Family
ID=14405637
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10536380A Pending JPS5728056A (en) | 1979-12-05 | 1980-07-29 | Dihydropyridazinone derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5728056A (en) |
-
1980
- 1980-07-29 JP JP10536380A patent/JPS5728056A/en active Pending
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