JPS579760A - Novel isothiourea derivative and its preparation - Google Patents
Novel isothiourea derivative and its preparationInfo
- Publication number
- JPS579760A JPS579760A JP8553180A JP8553180A JPS579760A JP S579760 A JPS579760 A JP S579760A JP 8553180 A JP8553180 A JP 8553180A JP 8553180 A JP8553180 A JP 8553180A JP S579760 A JPS579760 A JP S579760A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- preparation
- derivative
- prepared
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:An isothiourea derivative of formula I (R is hydroxy group or chlorine).
EXAMPLE: N-Cyano-N'-(2-chloroethyl)-S-methyl isothiourea.
USE: Useful as an intermediate for the preparation of cimetidine which blocks histamine H2-receptor and has the remedying activity to gastric ulcer, duodenal ulcer, etc. The compound can be prepared from aminoethanol and chloroethylamine which are easily available in the market, and accordingly it has excellent industrial value.
PROCESS: The compound of formula I is prepared by reacting an ethylamine derivative of formula II with dimethylcyanoimide dithiocarbonate of formula III in a polar solvent at a temperature between room temperature and 110°C for 0.5W5 hours. The polar solvent is selected from those which do not directly concern with the reaction, e.g. alcohols.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8553180A JPS579760A (en) | 1980-06-23 | 1980-06-23 | Novel isothiourea derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8553180A JPS579760A (en) | 1980-06-23 | 1980-06-23 | Novel isothiourea derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS579760A true JPS579760A (en) | 1982-01-19 |
Family
ID=13861465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8553180A Pending JPS579760A (en) | 1980-06-23 | 1980-06-23 | Novel isothiourea derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS579760A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6359938U (en) * | 1986-10-07 | 1988-04-21 |
-
1980
- 1980-06-23 JP JP8553180A patent/JPS579760A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6359938U (en) * | 1986-10-07 | 1988-04-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IE831282L (en) | Heterocyclylsulphonylureas | |
IE812713L (en) | Herbicidal nicotinamide derivatives | |
AU5047793A (en) | New derivatives of erythromycin, their preparation process, their use as medicaments | |
MD1761B2 (en) | 2,6-dihydroxypyridine ethers, process for obtaining thereof, herbicidal composition and method of weed plants control | |
JPS6471887A (en) | Organosilicon compound | |
PT75510A (en) | Process for the preparation of substituted phenylsulfonylurea derivatives having an herbicidal effect | |
YU45662B (en) | PROCEDURE FOR OBTAINING FENMEDIFAM OR DESMEDIFAM | |
JPS579760A (en) | Novel isothiourea derivative and its preparation | |
AU553927B2 (en) | Oxazolo- thiazolo- imidazolo (5,4-b) pyridines | |
DK159457C (en) | ANALOGY PROCEDURE FOR PREPARATION OF 7ALFA-ACYLTHIO-15,16-METHYLENE-3-OXO-17ALFA-PREGNA-1,4-DIEN-21,17-CARBOLACTONER | |
JPS5610175A (en) | Preparation of imidazole derivative | |
JPS5535067A (en) | Novel urea derivative and its preparation | |
DK554580A (en) | PROCEDURE FOR PREPARING CIMETIDIN | |
AU2196183A (en) | Substituted benzyl-cycloalkenylurea derivatives | |
ES8206506A1 (en) | Manufacture of aminoalkyl-furans or thiophenes | |
JPS5728064A (en) | Phthalazinone derivative | |
JPS5731652A (en) | Guanidine derivative | |
ES8406156A1 (en) | N-pteridinyl ureas, process for their preparation and their use. | |
JPS5711954A (en) | Novel nitroguanidine derivative and it preparation | |
JPS56122368A (en) | Guanidinothiazole compound and its preparation | |
JPS5764662A (en) | Alkylene disulfur derivative | |
JPS57120572A (en) | Guanidine derivative and its preparation | |
JPS5668666A (en) | Pyrrole derivative | |
JPS5731659A (en) | Isothiourea derivative | |
JPS5759862A (en) | Novel pyprolidonecarboxylic acid derivative, antiulcer agent containing said compound, and its preparation |