JPS5731659A - Isothiourea derivative - Google Patents
Isothiourea derivativeInfo
- Publication number
- JPS5731659A JPS5731659A JP10539080A JP10539080A JPS5731659A JP S5731659 A JPS5731659 A JP S5731659A JP 10539080 A JP10539080 A JP 10539080A JP 10539080 A JP10539080 A JP 10539080A JP S5731659 A JPS5731659 A JP S5731659A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- atom
- compound
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002541 isothioureas Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 206010020601 Hyperchlorhydria Diseases 0.000 abstract 1
- -1 N-Cyano-S-methyl-N'-[3-(4-phenylpiperazino)propyl]isothiourea Chemical compound 0.000 abstract 1
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 208000000718 duodenal ulcer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 201000005917 gastric ulcer Diseases 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 208000011906 peptic ulcer disease Diseases 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NEW MATERIAL:The titled compound of formula I (R1 is alkyl, cylohexyl or benzyl; R2 is alkyl, cyclohexyl or phenyl; R1 and R2 may together form a 5- membered, 6-membered or bicyclic hetero ring containing one N atom, two N atoms, or one N atom and one O atom; R3 is alkyl; m is 3W5).
EXAMPLE: N-Cyano-S-methyl-N'-[3-(4-phenylpiperazino)propyl]isothiourea.
USE: Remedy and preventive for peptic ulcer. It is effective to hyperacidity, gastric ulcer, and duodenal ulcer. It is also useful as an intermediate of the compound having similar activities.
PROCESS: The compound of formula I is prepared by reacting the amine derivative of formula II with dialkyl cyanodithioimide carbonate derivative of formula III (R4 is alkyl) in the absence of solvent or in a solvent such as ethanol, chloroform, etc., at room temperature or under cooling.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10539080A JPS5731659A (en) | 1980-07-29 | 1980-07-29 | Isothiourea derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10539080A JPS5731659A (en) | 1980-07-29 | 1980-07-29 | Isothiourea derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5731659A true JPS5731659A (en) | 1982-02-20 |
| JPH0144694B2 JPH0144694B2 (en) | 1989-09-29 |
Family
ID=14406312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10539080A Granted JPS5731659A (en) | 1980-07-29 | 1980-07-29 | Isothiourea derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5731659A (en) |
-
1980
- 1980-07-29 JP JP10539080A patent/JPS5731659A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0144694B2 (en) | 1989-09-29 |
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