JPS5728062A - 6-amino-3 2h pyridazinone derivative - Google Patents

6-amino-3 2h pyridazinone derivative

Info

Publication number
JPS5728062A
JPS5728062A JP10538780A JP10538780A JPS5728062A JP S5728062 A JPS5728062 A JP S5728062A JP 10538780 A JP10538780 A JP 10538780A JP 10538780 A JP10538780 A JP 10538780A JP S5728062 A JPS5728062 A JP S5728062A
Authority
JP
Japan
Prior art keywords
formula
expressed
alkyl
ulcer
gastric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10538780A
Other languages
Japanese (ja)
Other versions
JPS6340189B2 (en
Inventor
Toshihiro Yamada
Hiroshi Shimamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MORISHITA SEIYAKU KK
Morishita Pharmaceuticals Co Ltd
Original Assignee
MORISHITA SEIYAKU KK
Morishita Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MORISHITA SEIYAKU KK, Morishita Pharmaceuticals Co Ltd filed Critical MORISHITA SEIYAKU KK
Priority to JP10538780A priority Critical patent/JPS5728062A/en
Publication of JPS5728062A publication Critical patent/JPS5728062A/en
Publication of JPS6340189B2 publication Critical patent/JPS6340189B2/ja
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The titled compound expressed by formula I (R1 is H or alkyl; R2 is alkyl or phenyl or R1 and R2 together form a 5- or 6-membered heterocyclic ring containing N and/or O; R3 is lower alkyl; Z is S or -CH2-; m is an integer 1W3; n is 0 or an integer 1W3).
EXAMPLE: N-Cyano-N'-[ 3-( 6-dimethylamino-3-oxo-2-pyridazinyl )propyl ]-S-methylisothiourea.
USE: A medicine, useful as a remedy and a preventing agent against peptic ulcers, e.g. gastric hyperacidity, gastric ulcer and duodenal ulcer, or an intermediate for preparing another compound having the similar action, and capable of exhibiting the activity of inhibiting the gastric juice secretion, and inhibiting the development of experimental ulcers, e.g. the aspirin, stress or Shay ulcer, with prolonged action, weak toxicity and improved chemical resistance.
PROCESS: An amine derivative expressed by formula II is reacted with a dialkyl cyanodithioimidocarbonate expressed by formula III (R4 is lower alkyl) to give the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP10538780A 1980-07-29 1980-07-29 6-amino-3 2h pyridazinone derivative Granted JPS5728062A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10538780A JPS5728062A (en) 1980-07-29 1980-07-29 6-amino-3 2h pyridazinone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10538780A JPS5728062A (en) 1980-07-29 1980-07-29 6-amino-3 2h pyridazinone derivative

Publications (2)

Publication Number Publication Date
JPS5728062A true JPS5728062A (en) 1982-02-15
JPS6340189B2 JPS6340189B2 (en) 1988-08-10

Family

ID=14406237

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10538780A Granted JPS5728062A (en) 1980-07-29 1980-07-29 6-amino-3 2h pyridazinone derivative

Country Status (1)

Country Link
JP (1) JPS5728062A (en)

Also Published As

Publication number Publication date
JPS6340189B2 (en) 1988-08-10

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