JPS5728062A - 6-amino-3 2h pyridazinone derivative - Google Patents
6-amino-3 2h pyridazinone derivativeInfo
- Publication number
- JPS5728062A JPS5728062A JP10538780A JP10538780A JPS5728062A JP S5728062 A JPS5728062 A JP S5728062A JP 10538780 A JP10538780 A JP 10538780A JP 10538780 A JP10538780 A JP 10538780A JP S5728062 A JPS5728062 A JP S5728062A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- expressed
- alkyl
- ulcer
- gastric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The titled compound expressed by formula I (R1 is H or alkyl; R2 is alkyl or phenyl or R1 and R2 together form a 5- or 6-membered heterocyclic ring containing N and/or O; R3 is lower alkyl; Z is S or -CH2-; m is an integer 1W3; n is 0 or an integer 1W3).
EXAMPLE: N-Cyano-N'-[ 3-( 6-dimethylamino-3-oxo-2-pyridazinyl )propyl ]-S-methylisothiourea.
USE: A medicine, useful as a remedy and a preventing agent against peptic ulcers, e.g. gastric hyperacidity, gastric ulcer and duodenal ulcer, or an intermediate for preparing another compound having the similar action, and capable of exhibiting the activity of inhibiting the gastric juice secretion, and inhibiting the development of experimental ulcers, e.g. the aspirin, stress or Shay ulcer, with prolonged action, weak toxicity and improved chemical resistance.
PROCESS: An amine derivative expressed by formula II is reacted with a dialkyl cyanodithioimidocarbonate expressed by formula III (R4 is lower alkyl) to give the compound expressed by formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10538780A JPS5728062A (en) | 1980-07-29 | 1980-07-29 | 6-amino-3 2h pyridazinone derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10538780A JPS5728062A (en) | 1980-07-29 | 1980-07-29 | 6-amino-3 2h pyridazinone derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5728062A true JPS5728062A (en) | 1982-02-15 |
JPS6340189B2 JPS6340189B2 (en) | 1988-08-10 |
Family
ID=14406237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10538780A Granted JPS5728062A (en) | 1980-07-29 | 1980-07-29 | 6-amino-3 2h pyridazinone derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5728062A (en) |
-
1980
- 1980-07-29 JP JP10538780A patent/JPS5728062A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6340189B2 (en) | 1988-08-10 |
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