JPS5728005A - Pharmaceutical composition having diuretic, hypotensive and antihydropic activity - Google Patents

Pharmaceutical composition having diuretic, hypotensive and antihydropic activity

Info

Publication number
JPS5728005A
JPS5728005A JP10327380A JP10327380A JPS5728005A JP S5728005 A JPS5728005 A JP S5728005A JP 10327380 A JP10327380 A JP 10327380A JP 10327380 A JP10327380 A JP 10327380A JP S5728005 A JPS5728005 A JP S5728005A
Authority
JP
Japan
Prior art keywords
compound
formula
antihydropic
hypotensive
diuretic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10327380A
Other languages
Japanese (ja)
Other versions
JPS6157287B2 (en
Inventor
Yasuo Suzuki
Haruo Onishi
Koji Kojiyaku
Kazuo Yamaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Original Assignee
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharmaceutical Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Priority to JP10327380A priority Critical patent/JPS5728005A/en
Priority to US06/281,243 priority patent/US4421919A/en
Priority to GB8120930A priority patent/GB2081091B/en
Priority to FR8114439A priority patent/FR2487196A1/en
Priority to DE19813129719 priority patent/DE3129719C2/en
Publication of JPS5728005A publication Critical patent/JPS5728005A/en
Publication of JPS6157287B2 publication Critical patent/JPS6157287B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

PURPOSE: To prepare the titled compositin having high safety and effect to the remedy of dropsy, congestive heart, hypertension, etc., by using 6-chloro-4-oxyimono-1-acyl-1,2,3,4-tetrahydroquinoline (new material) or its salt as main component.
CONSTITUTION: The titled pharmaceutical composition is prepared by using the compound of formula (R is 1W4C alkyl, phenyl-substituted lower alkyl or phenylalkenyl) as a main component. The compound of formula has diuretic, hypotensive and antihydropic activities at the same time, and extremely high safety. It is used in the form of oral administration, suppository, injection, ointment, etc., together with conventional pharmaceutical carrier, base or diluent. The compound of formula is novel compound and it prepared by (1) acylating p-chloroaniline, (2) cylizing the product to obtain 6-chloro-4-oxo-1,2,3,4-tetrahydroquinoline, (3) reacting the compound with acid anhydride, etc., and (4) converting the product to oxime.
COPYRIGHT: (C)1982,JPO&Japio
JP10327380A 1980-07-28 1980-07-28 Pharmaceutical composition having diuretic, hypotensive and antihydropic activity Granted JPS5728005A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP10327380A JPS5728005A (en) 1980-07-28 1980-07-28 Pharmaceutical composition having diuretic, hypotensive and antihydropic activity
US06/281,243 US4421919A (en) 1980-07-28 1981-07-07 4-Oximino-1,2,3,4-tetrahydroquinoline derivatives
GB8120930A GB2081091B (en) 1980-07-28 1981-07-07 Hypotensive diuretic pharmaceutical compositions containing tetrahydroquinoline derivatives
FR8114439A FR2487196A1 (en) 1980-07-28 1981-07-24 PHARMACEUTICAL COMPOSITION PRODUCING DIURETIC, HYPOTENSE AND ANTI-EDEMATOUS EFFECTS BASED ON QUINOLINE DERIVATIVE
DE19813129719 DE3129719C2 (en) 1980-07-28 1981-07-28 Pharmaceutical agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10327380A JPS5728005A (en) 1980-07-28 1980-07-28 Pharmaceutical composition having diuretic, hypotensive and antihydropic activity

Publications (2)

Publication Number Publication Date
JPS5728005A true JPS5728005A (en) 1982-02-15
JPS6157287B2 JPS6157287B2 (en) 1986-12-06

Family

ID=14349771

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10327380A Granted JPS5728005A (en) 1980-07-28 1980-07-28 Pharmaceutical composition having diuretic, hypotensive and antihydropic activity

Country Status (1)

Country Link
JP (1) JPS5728005A (en)

Also Published As

Publication number Publication date
JPS6157287B2 (en) 1986-12-06

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