JPS5728005A - Pharmaceutical composition having diuretic, hypotensive and antihydropic activity - Google Patents
Pharmaceutical composition having diuretic, hypotensive and antihydropic activityInfo
- Publication number
- JPS5728005A JPS5728005A JP10327380A JP10327380A JPS5728005A JP S5728005 A JPS5728005 A JP S5728005A JP 10327380 A JP10327380 A JP 10327380A JP 10327380 A JP10327380 A JP 10327380A JP S5728005 A JPS5728005 A JP S5728005A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- antihydropic
- hypotensive
- diuretic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
PURPOSE: To prepare the titled compositin having high safety and effect to the remedy of dropsy, congestive heart, hypertension, etc., by using 6-chloro-4-oxyimono-1-acyl-1,2,3,4-tetrahydroquinoline (new material) or its salt as main component.
CONSTITUTION: The titled pharmaceutical composition is prepared by using the compound of formula (R is 1W4C alkyl, phenyl-substituted lower alkyl or phenylalkenyl) as a main component. The compound of formula has diuretic, hypotensive and antihydropic activities at the same time, and extremely high safety. It is used in the form of oral administration, suppository, injection, ointment, etc., together with conventional pharmaceutical carrier, base or diluent. The compound of formula is novel compound and it prepared by (1) acylating p-chloroaniline, (2) cylizing the product to obtain 6-chloro-4-oxo-1,2,3,4-tetrahydroquinoline, (3) reacting the compound with acid anhydride, etc., and (4) converting the product to oxime.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10327380A JPS5728005A (en) | 1980-07-28 | 1980-07-28 | Pharmaceutical composition having diuretic, hypotensive and antihydropic activity |
US06/281,243 US4421919A (en) | 1980-07-28 | 1981-07-07 | 4-Oximino-1,2,3,4-tetrahydroquinoline derivatives |
GB8120930A GB2081091B (en) | 1980-07-28 | 1981-07-07 | Hypotensive diuretic pharmaceutical compositions containing tetrahydroquinoline derivatives |
FR8114439A FR2487196A1 (en) | 1980-07-28 | 1981-07-24 | PHARMACEUTICAL COMPOSITION PRODUCING DIURETIC, HYPOTENSE AND ANTI-EDEMATOUS EFFECTS BASED ON QUINOLINE DERIVATIVE |
DE19813129719 DE3129719C2 (en) | 1980-07-28 | 1981-07-28 | Pharmaceutical agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10327380A JPS5728005A (en) | 1980-07-28 | 1980-07-28 | Pharmaceutical composition having diuretic, hypotensive and antihydropic activity |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5728005A true JPS5728005A (en) | 1982-02-15 |
JPS6157287B2 JPS6157287B2 (en) | 1986-12-06 |
Family
ID=14349771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10327380A Granted JPS5728005A (en) | 1980-07-28 | 1980-07-28 | Pharmaceutical composition having diuretic, hypotensive and antihydropic activity |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5728005A (en) |
-
1980
- 1980-07-28 JP JP10327380A patent/JPS5728005A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6157287B2 (en) | 1986-12-06 |
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