JPS5726676A - Preparation of oxirane derivative - Google Patents

Preparation of oxirane derivative

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Publication number
JPS5726676A
JPS5726676A JP10120980A JP10120980A JPS5726676A JP S5726676 A JPS5726676 A JP S5726676A JP 10120980 A JP10120980 A JP 10120980A JP 10120980 A JP10120980 A JP 10120980A JP S5726676 A JPS5726676 A JP S5726676A
Authority
JP
Japan
Prior art keywords
propanol derivative
formula
aromatic alcohol
equimolar
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10120980A
Other languages
Japanese (ja)
Inventor
Shinobu Iriuchijima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP10120980A priority Critical patent/JPS5726676A/en
Publication of JPS5726676A publication Critical patent/JPS5726676A/en
Pending legal-status Critical Current

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Abstract

PURPOSE: To obtain the titled substance, an intermediate for synthesizing a compound useful as a remedy for arrhythmia, etc. by one stage easily, by reacting a readily obtainable propanol derivative as raw material with an aromatic alcohol without using epichlorohydrin, a carcinogenic substance.
CONSTITUTION: A propanol derivative shown by the formula I (Y is H or acyl) is reacted with an aromatic alcohol, e.g., phenol, 4-chlorophenol, 1-naphtol, etc. shown by the formula ArOH (Ar is aromatic group) in the presence of a base, e.g., sodium methoxide, sodium hydroxide, etc. in a solvent, e.g., methanol, diethyl ether, etc. at room temperature to 80°C, to give a compound shown by the formula II. Preferably the amount of the base used is equimolar or more to about 5mol based on propanol derivative, and the amount of the propanol derivative used is equimolar to about 5mol based on aromatic alcohol.
COPYRIGHT: (C)1982,JPO&Japio
JP10120980A 1980-07-25 1980-07-25 Preparation of oxirane derivative Pending JPS5726676A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10120980A JPS5726676A (en) 1980-07-25 1980-07-25 Preparation of oxirane derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10120980A JPS5726676A (en) 1980-07-25 1980-07-25 Preparation of oxirane derivative

Publications (1)

Publication Number Publication Date
JPS5726676A true JPS5726676A (en) 1982-02-12

Family

ID=14294524

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10120980A Pending JPS5726676A (en) 1980-07-25 1980-07-25 Preparation of oxirane derivative

Country Status (1)

Country Link
JP (1) JPS5726676A (en)

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