JPS5726676A - Preparation of oxirane derivative - Google Patents
Preparation of oxirane derivativeInfo
- Publication number
- JPS5726676A JPS5726676A JP10120980A JP10120980A JPS5726676A JP S5726676 A JPS5726676 A JP S5726676A JP 10120980 A JP10120980 A JP 10120980A JP 10120980 A JP10120980 A JP 10120980A JP S5726676 A JPS5726676 A JP S5726676A
- Authority
- JP
- Japan
- Prior art keywords
- propanol derivative
- formula
- aromatic alcohol
- equimolar
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Epoxy Compounds (AREA)
Abstract
PURPOSE: To obtain the titled substance, an intermediate for synthesizing a compound useful as a remedy for arrhythmia, etc. by one stage easily, by reacting a readily obtainable propanol derivative as raw material with an aromatic alcohol without using epichlorohydrin, a carcinogenic substance.
CONSTITUTION: A propanol derivative shown by the formula I (Y is H or acyl) is reacted with an aromatic alcohol, e.g., phenol, 4-chlorophenol, 1-naphtol, etc. shown by the formula ArOH (Ar is aromatic group) in the presence of a base, e.g., sodium methoxide, sodium hydroxide, etc. in a solvent, e.g., methanol, diethyl ether, etc. at room temperature to 80°C, to give a compound shown by the formula II. Preferably the amount of the base used is equimolar or more to about 5mol based on propanol derivative, and the amount of the propanol derivative used is equimolar to about 5mol based on aromatic alcohol.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10120980A JPS5726676A (en) | 1980-07-25 | 1980-07-25 | Preparation of oxirane derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10120980A JPS5726676A (en) | 1980-07-25 | 1980-07-25 | Preparation of oxirane derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5726676A true JPS5726676A (en) | 1982-02-12 |
Family
ID=14294524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10120980A Pending JPS5726676A (en) | 1980-07-25 | 1980-07-25 | Preparation of oxirane derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5726676A (en) |
-
1980
- 1980-07-25 JP JP10120980A patent/JPS5726676A/en active Pending
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