JPS5726677A - Preparation of oxirane compound - Google Patents
Preparation of oxirane compoundInfo
- Publication number
- JPS5726677A JPS5726677A JP10121080A JP10121080A JPS5726677A JP S5726677 A JPS5726677 A JP S5726677A JP 10121080 A JP10121080 A JP 10121080A JP 10121080 A JP10121080 A JP 10121080A JP S5726677 A JPS5726677 A JP S5726677A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- bromohydrin
- compound shown
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Epoxy Compounds (AREA)
Abstract
PURPOSE: To obtain the titled substance, an intermediate for synthesizing a compound useful as a remedy for arrhythmia by a few processes easily, by treating a readily obtainable bromohydrin compound as a raw material with a base without using epichlorohydrin, a carcinogenic substance.
CONSTITUTION: A bromohydrin compound [e.g., 1-bromo-2-acetoxy-3-(1-naphtoxy)propane, etc.] shown by the formula I (Ar is aromatic group; R is lower alkyl) is treated with a base, e.g., sodium methoxide, potassium hydroxide, etc. at about room temperature, to give a compound shown by the formula II. The amount of the base used is preferably equimolar to about 2mol based on bromohydrin compound shown by the formula I. The compound shown by the formula I can be easily synthesized by reacting a diol compound shown by the formula III with hydrobromic acid and a lower fatty acid shown by the formula IV.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10121080A JPS5726677A (en) | 1980-07-25 | 1980-07-25 | Preparation of oxirane compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10121080A JPS5726677A (en) | 1980-07-25 | 1980-07-25 | Preparation of oxirane compound |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5726677A true JPS5726677A (en) | 1982-02-12 |
Family
ID=14294549
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10121080A Pending JPS5726677A (en) | 1980-07-25 | 1980-07-25 | Preparation of oxirane compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5726677A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4568759A (en) * | 1984-03-08 | 1986-02-04 | The Dow Chemical Company | Preparation of epoxides |
WO1998034930A1 (en) * | 1997-02-07 | 1998-08-13 | Shell Internationale Research Maatschappij B.V. | Process for the manufacture of epoxy compounds |
WO2002088105A1 (en) * | 2001-04-27 | 2002-11-07 | Eisai Co., Ltd. | Process for producing oxirane compound |
-
1980
- 1980-07-25 JP JP10121080A patent/JPS5726677A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4568759A (en) * | 1984-03-08 | 1986-02-04 | The Dow Chemical Company | Preparation of epoxides |
WO1998034930A1 (en) * | 1997-02-07 | 1998-08-13 | Shell Internationale Research Maatschappij B.V. | Process for the manufacture of epoxy compounds |
US6001954A (en) * | 1997-02-07 | 1999-12-14 | Shell Oil Company | Process for the manufacture of epoxy compounds |
US6235870B1 (en) | 1997-02-07 | 2001-05-22 | Shell Oil Company | Dehydrohalogenation of poly (phenylhalo-b-hydroxypropyl ether) to form polyepoxide |
WO2002088105A1 (en) * | 2001-04-27 | 2002-11-07 | Eisai Co., Ltd. | Process for producing oxirane compound |
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