JPS5726677A - Preparation of oxirane compound - Google Patents

Preparation of oxirane compound

Info

Publication number
JPS5726677A
JPS5726677A JP10121080A JP10121080A JPS5726677A JP S5726677 A JPS5726677 A JP S5726677A JP 10121080 A JP10121080 A JP 10121080A JP 10121080 A JP10121080 A JP 10121080A JP S5726677 A JPS5726677 A JP S5726677A
Authority
JP
Japan
Prior art keywords
formula
compound
bromohydrin
compound shown
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10121080A
Other languages
Japanese (ja)
Inventor
Shinobu Iriuchijima
Natsuko Kojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP10121080A priority Critical patent/JPS5726677A/en
Publication of JPS5726677A publication Critical patent/JPS5726677A/en
Pending legal-status Critical Current

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Abstract

PURPOSE: To obtain the titled substance, an intermediate for synthesizing a compound useful as a remedy for arrhythmia by a few processes easily, by treating a readily obtainable bromohydrin compound as a raw material with a base without using epichlorohydrin, a carcinogenic substance.
CONSTITUTION: A bromohydrin compound [e.g., 1-bromo-2-acetoxy-3-(1-naphtoxy)propane, etc.] shown by the formula I (Ar is aromatic group; R is lower alkyl) is treated with a base, e.g., sodium methoxide, potassium hydroxide, etc. at about room temperature, to give a compound shown by the formula II. The amount of the base used is preferably equimolar to about 2mol based on bromohydrin compound shown by the formula I. The compound shown by the formula I can be easily synthesized by reacting a diol compound shown by the formula III with hydrobromic acid and a lower fatty acid shown by the formula IV.
COPYRIGHT: (C)1982,JPO&Japio
JP10121080A 1980-07-25 1980-07-25 Preparation of oxirane compound Pending JPS5726677A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10121080A JPS5726677A (en) 1980-07-25 1980-07-25 Preparation of oxirane compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10121080A JPS5726677A (en) 1980-07-25 1980-07-25 Preparation of oxirane compound

Publications (1)

Publication Number Publication Date
JPS5726677A true JPS5726677A (en) 1982-02-12

Family

ID=14294549

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10121080A Pending JPS5726677A (en) 1980-07-25 1980-07-25 Preparation of oxirane compound

Country Status (1)

Country Link
JP (1) JPS5726677A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568759A (en) * 1984-03-08 1986-02-04 The Dow Chemical Company Preparation of epoxides
WO1998034930A1 (en) * 1997-02-07 1998-08-13 Shell Internationale Research Maatschappij B.V. Process for the manufacture of epoxy compounds
WO2002088105A1 (en) * 2001-04-27 2002-11-07 Eisai Co., Ltd. Process for producing oxirane compound

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568759A (en) * 1984-03-08 1986-02-04 The Dow Chemical Company Preparation of epoxides
WO1998034930A1 (en) * 1997-02-07 1998-08-13 Shell Internationale Research Maatschappij B.V. Process for the manufacture of epoxy compounds
US6001954A (en) * 1997-02-07 1999-12-14 Shell Oil Company Process for the manufacture of epoxy compounds
US6235870B1 (en) 1997-02-07 2001-05-22 Shell Oil Company Dehydrohalogenation of poly (phenylhalo-b-hydroxypropyl ether) to form polyepoxide
WO2002088105A1 (en) * 2001-04-27 2002-11-07 Eisai Co., Ltd. Process for producing oxirane compound

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