JPS57175186A - Novel vitamin e derivative and its preparation - Google Patents
Novel vitamin e derivative and its preparationInfo
- Publication number
- JPS57175186A JPS57175186A JP6005381A JP6005381A JPS57175186A JP S57175186 A JPS57175186 A JP S57175186A JP 6005381 A JP6005381 A JP 6005381A JP 6005381 A JP6005381 A JP 6005381A JP S57175186 A JPS57175186 A JP S57175186A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- compound
- preparation
- reacting
- novel vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:2,5,7,8,-Tetramethyl-2-(4',8',12'-trimethyl-tridecyl)-6-(2"hydroxy- 3"-isopropyl-aminopropoxy)-chroman of formulaI.
USE: A vitamin E derivative. The compound is expected to be effective as a hypotensor or as a remedy for extrasystole.
PROCESS: The objective compound of formulaIcan be prepared by reacting the compound of formula II with epichlorohydrin, and then reacting the resultant intermediate with isopropylamine of formula III. The reaction is carried out in a solvent such as THF, dioxane, etc. in the presence of a strong base such as sodium hydride, metallic sodium, etc. at room temperature or preferably at the refluxing temperature, for about 12W24hrs.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6005381A JPS57175186A (en) | 1981-04-20 | 1981-04-20 | Novel vitamin e derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6005381A JPS57175186A (en) | 1981-04-20 | 1981-04-20 | Novel vitamin e derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57175186A true JPS57175186A (en) | 1982-10-28 |
Family
ID=13130952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6005381A Pending JPS57175186A (en) | 1981-04-20 | 1981-04-20 | Novel vitamin e derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57175186A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0683164A1 (en) * | 1994-05-20 | 1995-11-22 | Senju Pharmaceutical Co., Ltd. | Tocopherol derivatives |
WO1999062896A1 (en) * | 1998-06-03 | 1999-12-09 | Young Dae Kim | Novel polyoxypropylenepolyoxyethylene vitamin e and preparation thereof |
KR100438402B1 (en) * | 2001-05-30 | 2004-07-02 | 김영대 | Oil-in-water type emulsion cosmetic composition with low viscosity using polyoxypropylene-polyoxyethylene vitamin e |
US8148424B2 (en) | 1998-09-23 | 2012-04-03 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
-
1981
- 1981-04-20 JP JP6005381A patent/JPS57175186A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0683164A1 (en) * | 1994-05-20 | 1995-11-22 | Senju Pharmaceutical Co., Ltd. | Tocopherol derivatives |
WO1999062896A1 (en) * | 1998-06-03 | 1999-12-09 | Young Dae Kim | Novel polyoxypropylenepolyoxyethylene vitamin e and preparation thereof |
US8148424B2 (en) | 1998-09-23 | 2012-04-03 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
US8664264B2 (en) | 1998-09-23 | 2014-03-04 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
KR100438402B1 (en) * | 2001-05-30 | 2004-07-02 | 김영대 | Oil-in-water type emulsion cosmetic composition with low viscosity using polyoxypropylene-polyoxyethylene vitamin e |
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