JPS57175186A - Novel vitamin e derivative and its preparation - Google Patents

Novel vitamin e derivative and its preparation

Info

Publication number
JPS57175186A
JPS57175186A JP6005381A JP6005381A JPS57175186A JP S57175186 A JPS57175186 A JP S57175186A JP 6005381 A JP6005381 A JP 6005381A JP 6005381 A JP6005381 A JP 6005381A JP S57175186 A JPS57175186 A JP S57175186A
Authority
JP
Japan
Prior art keywords
derivative
compound
preparation
reacting
novel vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6005381A
Other languages
Japanese (ja)
Inventor
Dotaro Fujimoto
Giichi Funatsukuri
Ryuichi Fukui
Shuhei Takamatsu
Takeshi Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujimoto Pharmaceutical Corp
Original Assignee
Fujimoto Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujimoto Pharmaceutical Corp filed Critical Fujimoto Pharmaceutical Corp
Priority to JP6005381A priority Critical patent/JPS57175186A/en
Publication of JPS57175186A publication Critical patent/JPS57175186A/en
Pending legal-status Critical Current

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  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:2,5,7,8,-Tetramethyl-2-(4',8',12'-trimethyl-tridecyl)-6-(2"hydroxy- 3"-isopropyl-aminopropoxy)-chroman of formulaI.
USE: A vitamin E derivative. The compound is expected to be effective as a hypotensor or as a remedy for extrasystole.
PROCESS: The objective compound of formulaIcan be prepared by reacting the compound of formula II with epichlorohydrin, and then reacting the resultant intermediate with isopropylamine of formula III. The reaction is carried out in a solvent such as THF, dioxane, etc. in the presence of a strong base such as sodium hydride, metallic sodium, etc. at room temperature or preferably at the refluxing temperature, for about 12W24hrs.
COPYRIGHT: (C)1982,JPO&Japio
JP6005381A 1981-04-20 1981-04-20 Novel vitamin e derivative and its preparation Pending JPS57175186A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6005381A JPS57175186A (en) 1981-04-20 1981-04-20 Novel vitamin e derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6005381A JPS57175186A (en) 1981-04-20 1981-04-20 Novel vitamin e derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS57175186A true JPS57175186A (en) 1982-10-28

Family

ID=13130952

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6005381A Pending JPS57175186A (en) 1981-04-20 1981-04-20 Novel vitamin e derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS57175186A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0683164A1 (en) * 1994-05-20 1995-11-22 Senju Pharmaceutical Co., Ltd. Tocopherol derivatives
WO1999062896A1 (en) * 1998-06-03 1999-12-09 Young Dae Kim Novel polyoxypropylenepolyoxyethylene vitamin e and preparation thereof
KR100438402B1 (en) * 2001-05-30 2004-07-02 김영대 Oil-in-water type emulsion cosmetic composition with low viscosity using polyoxypropylene-polyoxyethylene vitamin e
US8148424B2 (en) 1998-09-23 2012-04-03 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0683164A1 (en) * 1994-05-20 1995-11-22 Senju Pharmaceutical Co., Ltd. Tocopherol derivatives
WO1999062896A1 (en) * 1998-06-03 1999-12-09 Young Dae Kim Novel polyoxypropylenepolyoxyethylene vitamin e and preparation thereof
US8148424B2 (en) 1998-09-23 2012-04-03 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
US8664264B2 (en) 1998-09-23 2014-03-04 Research Development Foundation Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
KR100438402B1 (en) * 2001-05-30 2004-07-02 김영대 Oil-in-water type emulsion cosmetic composition with low viscosity using polyoxypropylene-polyoxyethylene vitamin e

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