JPS572269A - Preparation of 1-methyl-5- p-toluoyl pyrrole-2-acetic acid - Google Patents
Preparation of 1-methyl-5- p-toluoyl pyrrole-2-acetic acidInfo
- Publication number
- JPS572269A JPS572269A JP7682680A JP7682680A JPS572269A JP S572269 A JPS572269 A JP S572269A JP 7682680 A JP7682680 A JP 7682680A JP 7682680 A JP7682680 A JP 7682680A JP S572269 A JPS572269 A JP S572269A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- solvent
- compound
- toluoyl
- pyrrole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000002904 solvent Substances 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- WKUBFPPJDMDEFL-UHFFFAOYSA-N (4-methylphenyl)-(1-methylpyrrol-2-yl)methanone Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=CN1C WKUBFPPJDMDEFL-UHFFFAOYSA-N 0.000 abstract 1
- OXHNLMTVIGZXSG-UHFFFAOYSA-N 1-Methylpyrrole Chemical compound CN1C=CC=C1 OXHNLMTVIGZXSG-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- -1 morpholino, piperidino Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- SVOOVMQUISJERI-UHFFFAOYSA-K rhodium(3+);triacetate Chemical compound [Rh+3].CC([O-])=O.CC([O-])=O.CC([O-])=O SVOOVMQUISJERI-UHFFFAOYSA-K 0.000 abstract 1
Landscapes
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7682680A JPS572269A (en) | 1980-06-06 | 1980-06-06 | Preparation of 1-methyl-5- p-toluoyl pyrrole-2-acetic acid |
| AT253481A AT374793B (de) | 1980-06-06 | 1981-06-05 | Verfahren zur herstellung von 1-methyl-5(p-toluoyl)-pyrrol-2-essigsaeure |
| CA000379152A CA1151188A (en) | 1980-06-06 | 1981-06-05 | Process for preparing 1-methyl-5-(p-toluoyl)pyrrole-2- acetic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7682680A JPS572269A (en) | 1980-06-06 | 1980-06-06 | Preparation of 1-methyl-5- p-toluoyl pyrrole-2-acetic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS572269A true JPS572269A (en) | 1982-01-07 |
| JPS649987B2 JPS649987B2 (enrdf_load_stackoverflow) | 1989-02-21 |
Family
ID=13616476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7682680A Granted JPS572269A (en) | 1980-06-06 | 1980-06-06 | Preparation of 1-methyl-5- p-toluoyl pyrrole-2-acetic acid |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS572269A (enrdf_load_stackoverflow) |
| AT (1) | AT374793B (enrdf_load_stackoverflow) |
| CA (1) | CA1151188A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873340A (en) * | 1986-05-29 | 1989-10-10 | Syntex (U.S.A.) Inc. | Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates |
| US4988822A (en) * | 1986-05-29 | 1991-01-29 | Syntex (U.S.A.) Inc. | Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates |
-
1980
- 1980-06-06 JP JP7682680A patent/JPS572269A/ja active Granted
-
1981
- 1981-06-05 CA CA000379152A patent/CA1151188A/en not_active Expired
- 1981-06-05 AT AT253481A patent/AT374793B/de not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873340A (en) * | 1986-05-29 | 1989-10-10 | Syntex (U.S.A.) Inc. | Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates |
| US4988822A (en) * | 1986-05-29 | 1991-01-29 | Syntex (U.S.A.) Inc. | Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates |
Also Published As
| Publication number | Publication date |
|---|---|
| ATA253481A (de) | 1983-10-15 |
| CA1151188A (en) | 1983-08-02 |
| JPS649987B2 (enrdf_load_stackoverflow) | 1989-02-21 |
| AT374793B (de) | 1984-05-25 |
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