JPS57154171A - Preparation of 5-fluorocytosine salt - Google Patents
Preparation of 5-fluorocytosine saltInfo
- Publication number
- JPS57154171A JPS57154171A JP4008481A JP4008481A JPS57154171A JP S57154171 A JPS57154171 A JP S57154171A JP 4008481 A JP4008481 A JP 4008481A JP 4008481 A JP4008481 A JP 4008481A JP S57154171 A JPS57154171 A JP S57154171A
- Authority
- JP
- Japan
- Prior art keywords
- carboxylic acid
- fluorocytosine
- acid
- give
- fluorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical class NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 title abstract 3
- 150000001735 carboxylic acids Chemical class 0.000 abstract 4
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 4
- 239000000543 intermediate Substances 0.000 abstract 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 239000004599 antimicrobial Substances 0.000 abstract 2
- 239000007806 chemical reaction intermediate Substances 0.000 abstract 2
- 229940104302 cytosine Drugs 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- LRMSQVBRUNSOJL-UHFFFAOYSA-N 2,2,3,3,3-pentafluoropropanoic acid Chemical compound OC(=O)C(F)(F)C(F)(F)F LRMSQVBRUNSOJL-UHFFFAOYSA-N 0.000 abstract 1
- PXRROZVNOOEPPZ-UHFFFAOYSA-N Flupropanate Chemical compound OC(=O)C(F)(F)C(F)F PXRROZVNOOEPPZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 229960004413 flucytosine Drugs 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4008481A JPS57154171A (en) | 1981-03-18 | 1981-03-18 | Preparation of 5-fluorocytosine salt |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4008481A JPS57154171A (en) | 1981-03-18 | 1981-03-18 | Preparation of 5-fluorocytosine salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57154171A true JPS57154171A (en) | 1982-09-22 |
| JPS6123793B2 JPS6123793B2 (enExample) | 1986-06-07 |
Family
ID=12571025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4008481A Granted JPS57154171A (en) | 1981-03-18 | 1981-03-18 | Preparation of 5-fluorocytosine salt |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57154171A (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4473691A (en) * | 1981-04-14 | 1984-09-25 | Daikin Kogyo Co., Ltd. | Process for preparing 5-fluorocytosine salt |
| CN110615767A (zh) * | 2019-10-26 | 2019-12-27 | 新乡拓新药业股份有限公司 | 一种合成5-氟胞嘧啶的方法 |
| CN110746360A (zh) * | 2019-10-26 | 2020-02-04 | 新乡拓新药业股份有限公司 | 一种合成5-氟胞嘧啶的方法 |
| US10995075B2 (en) | 2014-08-29 | 2021-05-04 | University Of Durham | Process for producing fluorocytosine and fluorocytosine derivatives |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51149287A (en) * | 1975-06-17 | 1976-12-22 | Daikin Ind Ltd | Process for preparing 5-fluorouracil |
-
1981
- 1981-03-18 JP JP4008481A patent/JPS57154171A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51149287A (en) * | 1975-06-17 | 1976-12-22 | Daikin Ind Ltd | Process for preparing 5-fluorouracil |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4473691A (en) * | 1981-04-14 | 1984-09-25 | Daikin Kogyo Co., Ltd. | Process for preparing 5-fluorocytosine salt |
| US10995075B2 (en) | 2014-08-29 | 2021-05-04 | University Of Durham | Process for producing fluorocytosine and fluorocytosine derivatives |
| CN110615767A (zh) * | 2019-10-26 | 2019-12-27 | 新乡拓新药业股份有限公司 | 一种合成5-氟胞嘧啶的方法 |
| CN110746360A (zh) * | 2019-10-26 | 2020-02-04 | 新乡拓新药业股份有限公司 | 一种合成5-氟胞嘧啶的方法 |
| CN110615767B (zh) * | 2019-10-26 | 2022-06-28 | 新乡拓新药业股份有限公司 | 一种合成5-氟胞嘧啶的方法 |
| CN110746360B (zh) * | 2019-10-26 | 2022-06-28 | 新乡拓新药业股份有限公司 | 一种合成5-氟胞嘧啶的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6123793B2 (enExample) | 1986-06-07 |
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