JPS57145830A - Optical resolution of 2-(4-chlorophenyl)-3-methylbutanoic acid - Google Patents

Optical resolution of 2-(4-chlorophenyl)-3-methylbutanoic acid

Info

Publication number
JPS57145830A
JPS57145830A JP56031248A JP3124881A JPS57145830A JP S57145830 A JPS57145830 A JP S57145830A JP 56031248 A JP56031248 A JP 56031248A JP 3124881 A JP3124881 A JP 3124881A JP S57145830 A JPS57145830 A JP S57145830A
Authority
JP
Japan
Prior art keywords
salt
cpa
diethylamine
acid
crystallized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56031248A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6321654B2 (enExample
Inventor
Hiroyuki Nohira
Hiroharu Terunuma
Shinji Koube
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP56031248A priority Critical patent/JPS57145830A/ja
Priority to US06/344,523 priority patent/US4376213A/en
Priority to HU82691A priority patent/HU191349B/hu
Priority to DE8282101759T priority patent/DE3260350D1/de
Priority to EP82101759A priority patent/EP0060466B1/en
Publication of JPS57145830A publication Critical patent/JPS57145830A/ja
Publication of JPS6321654B2 publication Critical patent/JPS6321654B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP56031248A 1981-03-06 1981-03-06 Optical resolution of 2-(4-chlorophenyl)-3-methylbutanoic acid Granted JPS57145830A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP56031248A JPS57145830A (en) 1981-03-06 1981-03-06 Optical resolution of 2-(4-chlorophenyl)-3-methylbutanoic acid
US06/344,523 US4376213A (en) 1981-03-06 1982-02-01 Method for optical resolution of 2-(4-chlorophenyl)-3-methylbutanoic acid
HU82691A HU191349B (en) 1981-03-06 1982-03-05 Process for preparing optically active isomers from 2-/4-chloro-phenyl/-3-methyl-butyric acid
DE8282101759T DE3260350D1 (en) 1981-03-06 1982-03-05 Method for optical resolution of 2-(4-chlorophenyl)-3-methyl-butanoic acid
EP82101759A EP0060466B1 (en) 1981-03-06 1982-03-05 Method for optical resolution of 2-(4-chlorophenyl)-3-methyl-butanoic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56031248A JPS57145830A (en) 1981-03-06 1981-03-06 Optical resolution of 2-(4-chlorophenyl)-3-methylbutanoic acid

Publications (2)

Publication Number Publication Date
JPS57145830A true JPS57145830A (en) 1982-09-09
JPS6321654B2 JPS6321654B2 (enExample) 1988-05-09

Family

ID=12326063

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56031248A Granted JPS57145830A (en) 1981-03-06 1981-03-06 Optical resolution of 2-(4-chlorophenyl)-3-methylbutanoic acid

Country Status (5)

Country Link
US (1) US4376213A (enExample)
EP (1) EP0060466B1 (enExample)
JP (1) JPS57145830A (enExample)
DE (1) DE3260350D1 (enExample)
HU (1) HU191349B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61186355A (ja) * 1985-02-13 1986-08-20 Nippon Kayaku Co Ltd 光学活性バリンの新規製造法
JPH0684332B2 (ja) * 1985-06-20 1994-10-26 住友化学工業株式会社 ａ−イソプロピル−ｐ−クロルフエニル酢酸の光学分割法
IT1222013B (it) * 1987-07-10 1990-08-31 Chimica Profarmaco Spa Ind Processo di risoluzione ottica di acido 2 (6 metossi 2 naftil) propionico
US5302751A (en) * 1992-01-21 1994-04-12 Ethyl Corporation Profen resolution

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450751A (en) * 1963-06-15 1969-06-17 Noguchi Inst The Continuous optical resolution of racemic glutamic acid or its salts
US3405159A (en) * 1964-11-17 1968-10-08 Merck & Co Inc Process for resolving racemic mixtures of optically-active enantiomorphs
JPS535134A (en) * 1976-06-30 1978-01-18 Sumitomo Chem Co Ltd Racemization of optical active 2-(4)chlorophenyl)-3-methylbutylic acid
GR64816B (en) * 1977-03-08 1980-06-03 Boots Co Ltd Resolution of flurbiprofen ii/iii
US4230860A (en) * 1978-11-06 1980-10-28 American Cyanamid Company Processes for the separation of enantiomers by selective crystallization

Also Published As

Publication number Publication date
EP0060466B1 (en) 1984-07-11
EP0060466A1 (en) 1982-09-22
JPS6321654B2 (enExample) 1988-05-09
DE3260350D1 (en) 1984-08-16
US4376213A (en) 1983-03-08
HU191349B (en) 1987-02-27

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