ES8504452A1 - Procedimiento para la obtencion de productos farmaceuticos solidos a base de particulas esfericas. - Google Patents

Procedimiento para la obtencion de productos farmaceuticos solidos a base de particulas esfericas.

Info

Publication number
ES8504452A1
ES8504452A1 ES529959A ES529959A ES8504452A1 ES 8504452 A1 ES8504452 A1 ES 8504452A1 ES 529959 A ES529959 A ES 529959A ES 529959 A ES529959 A ES 529959A ES 8504452 A1 ES8504452 A1 ES 8504452A1
Authority
ES
Spain
Prior art keywords
solution
single crystals
assistants
organic
crystals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529959A
Other languages
English (en)
Other versions
ES529959A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of ES8504452A1 publication Critical patent/ES8504452A1/es
Publication of ES529959A0 publication Critical patent/ES529959A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Jellies, Jams, And Syrups (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE PRODUCTOS FARMACEUTICOS SOLIDOS A BASE DE PARTICULAS ESFERICAS.COMPRENDE: A) AGITAR EN CRISTALIZADORES DE AGITACION O DE TUBO CONDUCTOS DE MARCHA RAPIDA Y CON UNA VELOCIDAD DE 50 A 1.000 REVOLUCIONES POR MINUTO, UNA SOLUCION ACUOSA, ORGANICA, U ORGANICO-ACUOSA, SATURADA; B) INOCULAR A LA SOLUCION DE LA ETAPA (A) CON GERMENES CRISTALINOS FINAMENTE MOLIDOS CON UN DIAMETRO DE PARTICULA H 300 2M; C) ENFRIAR LENTAMENTE A LA SOLUCION DE LA ETAPA (B), PARA OBTENER MONOCRISTALES ESFERICOS CON UN DIAMETRO DE 0,1 A 3 MM; D) SEPARAR A LOS CRISTALES DE LA SOLUCION; E) SECAR A LOS CRISTALES SEPARADOS A UNA TEMPERATURA ENTRE 40 Y 200JC; F) COMBINAR A LOS CRISTALES SECADOS CON LOS PRODUCTOS AUXILIARES FARMACEUTICOS CORRESPONDIENTES, O CON LAS SUSTANCIAS ACTIVAS FARMACEUTICAS CORRESPONDIENTES; Y G) CONFECCIONAR A LOS CRISTALES COMBINADOS POR RECUBRIMIENTO, TABLETAS O LLENADO EN CAPSULAS DE GELATINA DURA, EN PRODUCTOS FARMACEUTICOS SOLIDOS.
ES529959A 1983-02-23 1984-02-22 Procedimiento para la obtencion de productos farmaceuticos solidos a base de particulas esfericas. Granted ES529959A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833306250 DE3306250A1 (de) 1983-02-23 1983-02-23 Sphaerische einkristalle fuer pharmazeutische zwecke

Publications (2)

Publication Number Publication Date
ES8504452A1 true ES8504452A1 (es) 1985-04-16
ES529959A0 ES529959A0 (es) 1985-04-16

Family

ID=6191601

Family Applications (1)

Application Number Title Priority Date Filing Date
ES529959A Granted ES529959A0 (es) 1983-02-23 1984-02-22 Procedimiento para la obtencion de productos farmaceuticos solidos a base de particulas esfericas.

Country Status (11)

Country Link
US (1) US4632843A (es)
EP (1) EP0119480B1 (es)
JP (1) JPS59182290A (es)
AT (1) ATE40291T1 (es)
AU (1) AU561079B2 (es)
CA (1) CA1220421A (es)
DE (2) DE3306250A1 (es)
ES (1) ES529959A0 (es)
IL (1) IL71018A (es)
PT (1) PT78146B (es)
ZA (1) ZA841287B (es)

Families Citing this family (27)

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Publication number Priority date Publication date Assignee Title
ATE71293T1 (de) * 1986-09-18 1992-01-15 London Pharmacy Innovation Arzneiformulierung.
GB8628728D0 (en) * 1986-12-02 1987-01-07 Euro Celtique Sa Spheroids
US4874613A (en) * 1987-03-06 1989-10-17 Baker Cummins Pharmaceuticals, Inc. Taste concealing pharmaceutical dosage unit
FR2613619B1 (fr) * 1987-04-07 1993-10-15 Recherche Informatique Pharmacie Medicaments, produits dietetiques ou produits d'hygiene sous forme de compositions pulverulentes obtenues par adsorption de principes actifs sur un sucre a dissolution rapide
IL86211A (en) * 1987-05-04 1992-03-29 Ciba Geigy Ag Oral forms of administration for carbamazepine in the forms of stable aqueous suspension with delayed release and their preparation
GB8805695D0 (en) * 1988-03-10 1988-04-07 Nycomed As Enteric coated spheroidal granules
DE3911069A1 (de) * 1989-04-06 1990-10-11 Knoll Ag Einkristalle von ss-phenylpropiophenonen
DE4027927A1 (de) * 1990-09-04 1992-03-05 Bayer Ag Brausekomponente und verfahren zu ihrer herstellung
JP3447042B2 (ja) * 1997-07-23 2003-09-16 フロイント産業株式会社 単一物質球形粒の製造方法
DE19834876A1 (de) * 1998-08-01 2000-02-03 Aventis Res & Tech Gmbh & Co Verfahren zur Herstellung sphärischer Teilchen bei der Kristallisation
DE19901687B4 (de) 1999-01-18 2006-06-01 Grünenthal GmbH Opioide Analgetika mit kontrollierter Wirkstofffreisetzung
WO2000076480A2 (en) * 1999-06-11 2000-12-21 Eli Lilly And Company Pharmaceutical materials and methods for their preparation and use
US7001892B1 (en) 1999-06-11 2006-02-21 Purdue Research Foundation Pharmaceutical materials and methods for their preparation and use
FI20002217A (fi) * 1999-12-30 2001-07-01 Orion Yhtymae Oyj Inhalaatiopartikkelit
FI20010115A0 (fi) * 2001-01-18 2001-01-18 Orion Corp Menetelmä nanopartikkelien valmistamiseksi
JP4422488B2 (ja) * 2002-02-19 2010-02-24 テバ ファーマシューティカル インダストリーズ リミティド アトルバスタチンヘミカルシウム溶媒和物の脱溶媒和法及び有機溶媒を本質的に含まないアトルバスタチンヘミカルシウム
DE10218110A1 (de) * 2002-04-23 2003-11-20 Jenapharm Gmbh Verfahren zum Herstellen von Kristallen von Arzneimittelhilfsstoffen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen
DE10218106A1 (de) * 2002-04-23 2003-11-20 Jenapharm Gmbh Verfahren zum Herstellen von Kristallen von Arzneimittelwirkstoffen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen
WO2004000280A1 (en) * 2002-04-29 2003-12-31 Shire Laboraties, Inc. Pharmaceutical formulations with improved bioavailability
AT504996B1 (de) * 2007-03-02 2009-03-15 Andritz Tech & Asset Man Gmbh Verfahren und vorrichtung zur trocknung von kristallinen carbonsäuren
US20080268018A1 (en) * 2007-04-30 2008-10-30 Pacetti Stephen D Method for forming crystallized therapeutic agents on a medical device
JPWO2009072334A1 (ja) * 2007-12-03 2011-04-21 富田製薬株式会社 製剤用核粒子
CA2691554A1 (en) * 2010-02-01 2011-08-01 Michael Krautter Crystal growing device
US9905953B1 (en) 2016-09-30 2018-02-27 Slobodan Pavlovic High power spring-actuated electrical connector
EP3518690A4 (en) * 2016-10-03 2020-02-26 Höganäs Ab (publ) WHITE IRON BASED FOOD ADDITIVE
JP6989715B2 (ja) 2018-02-26 2022-01-05 ロイヤル プレシジョン プロダクツ，エルエルシー 高電力用途用のばね作動式電気コネクター
CN111498874B (zh) * 2020-02-21 2022-10-04 天津大学 一种大粒度碘化铯球晶及其制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA799930A (en) * 1968-11-26 Polderman Jacobus Process for rendering powders free flowing and the thus obtained powders
US2996431A (en) * 1953-12-16 1961-08-15 Barry Richard Henry Friable tablet and process for manufacturing same
US2853420A (en) * 1956-01-25 1958-09-23 Lowey Hans Ethyl cellulose coatings for shaped medicinal preparations
US3072533A (en) * 1960-11-15 1963-01-08 Henry J Johnson Crystalline vitamin d composition and method of preparing same
NL137432C (es) * 1964-08-13 1900-01-01
US3433872A (en) * 1966-11-25 1969-03-18 Hoffmann La Roche Palatable,free-flowing,non-agglomerating caffeine powder
FR7932M (es) * 1968-09-30 1970-05-19
US3854480A (en) * 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
CA942667A (en) * 1970-10-16 1974-02-26 Alejandro Zaffaroni Drug-delivery system
US3909444A (en) * 1971-08-05 1975-09-30 Ncr Co Microcapsule
FR2171934B1 (es) * 1972-02-16 1974-09-13 Rhone Poulenc Sa
US4123382A (en) * 1973-05-25 1978-10-31 Merck & Co., Inc. Method of microencapsulation
JPS53124634A (en) * 1974-08-15 1978-10-31 Shin Nihon Kagaku Kogyo Kk Production of table salt
JPS51113813A (en) * 1975-03-03 1976-10-07 Towa Kasei Kogyo Kk Pulverizing process of maltitol
SE418247B (sv) * 1975-11-17 1981-05-18 Haessle Ab Sett att framstella kroppar med reglerad frigoring av en aktiv komponent
DD146547A5 (de) * 1978-07-15 1981-02-18 Boehringer Sohn Ingelheim Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen
US4386120A (en) * 1980-01-07 1983-05-31 Nippon Kayaku Kabushiki Kaisha Process for producing polyacrylic acid salt granules easily soluble in water
DE3000979A1 (de) * 1980-01-12 1981-07-23 Dr. Karl Thomae Gmbh, 7950 Biberach Neue dipyridamol-retardformen und verfahren zu ihrer herstellung
US4259315A (en) * 1980-06-13 1981-03-31 A. H. Robins Company, Inc. Controlled release potassium dosage form
US4479911A (en) * 1982-01-28 1984-10-30 Sandoz, Inc. Process for preparation of microspheres and modification of release rate of core material

Also Published As

Publication number Publication date
AU561079B2 (en) 1987-04-30
EP0119480A2 (de) 1984-09-26
EP0119480A3 (en) 1985-09-25
US4632843A (en) 1986-12-30
JPH0573727B2 (es) 1993-10-15
JPS59182290A (ja) 1984-10-17
CA1220421A (en) 1987-04-14
AU2484384A (en) 1984-08-30
IL71018A (en) 1987-01-30
ATE40291T1 (de) 1989-02-15
DE3476337D1 (en) 1989-03-02
PT78146B (en) 1986-05-19
PT78146A (en) 1984-03-01
EP0119480B1 (de) 1989-01-25
IL71018A0 (en) 1984-05-31
DE3306250A1 (de) 1984-08-23
ZA841287B (en) 1984-10-31
ES529959A0 (es) 1985-04-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050212