JPS5446722A - Novel preparation of s-2-(3-aminopropyl-amino) ethyldihydrogenphosphorothioate monohydrate crystal - Google Patents
Novel preparation of s-2-(3-aminopropyl-amino) ethyldihydrogenphosphorothioate monohydrate crystalInfo
- Publication number
- JPS5446722A JPS5446722A JP11360177A JP11360177A JPS5446722A JP S5446722 A JPS5446722 A JP S5446722A JP 11360177 A JP11360177 A JP 11360177A JP 11360177 A JP11360177 A JP 11360177A JP S5446722 A JPS5446722 A JP S5446722A
- Authority
- JP
- Japan
- Prior art keywords
- crystal
- ethyldihydrogenphosphorothioate
- ethanol
- aminopropylamino
- monohydrate crystal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain the titled compound free from methanol, by suspending a polyhydrate crystal of S-2-(3-aminopropylamino) ethyldihydrogenphosphorothioate in ethanol, and by treating the suspension at a specific temperaure to transform the thioate into a monohydrate crystal.
CONSTITUTION: The titled compound is prepared by anyone of the following three methods: (A) A suspension of a polyhydrate crystal of S-2-(3-aminopropylamino)- ethyldihydrogenphosphorothioate in ethanol is treated in an ice bath or at a temperature of 60°C or below to transform the crystal into a monohydrate crystal to give the desired compound (B) A polyol containing or free from ethanol which is usually not used as a crystallization solvent is added to an aqueous solution of crude S-2-(3-aminopropylamino) ethyldihydroenphosphorothioate. (C) The aqueous solution is added to individual ethanol or polyol, or their mixture to crystallize the objective compound in a high yield.
USE: Radiation protectives.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11360177A JPS6041676B2 (en) | 1977-09-21 | 1977-09-21 | New method for producing S-2-(3-aminopropylamino)ethyldihydrodiene phosphorothioate monohydrate crystals |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11360177A JPS6041676B2 (en) | 1977-09-21 | 1977-09-21 | New method for producing S-2-(3-aminopropylamino)ethyldihydrodiene phosphorothioate monohydrate crystals |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5446722A true JPS5446722A (en) | 1979-04-12 |
JPS6041676B2 JPS6041676B2 (en) | 1985-09-18 |
Family
ID=14616338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11360177A Expired JPS6041676B2 (en) | 1977-09-21 | 1977-09-21 | New method for producing S-2-(3-aminopropylamino)ethyldihydrodiene phosphorothioate monohydrate crystals |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6041676B2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5591731A (en) * | 1992-07-31 | 1997-01-07 | U.S. Bioscience, Inc. | Crystalline amifostine compositions |
US6384259B1 (en) | 1998-11-16 | 2002-05-07 | Medimmune Oncology, Inc. | Stable amorphous amifostine compositions and dosage form |
US6407278B2 (en) | 1998-11-16 | 2002-06-18 | Medimmune Oncology, Inc. | Stable amorphous amifostine compositions and methods for the preparation and use of the same |
EP1243272A2 (en) | 1992-07-31 | 2002-09-25 | Medimmune Oncology, Inc. | Crystalline amifostine compositions and methods for the preparation and use of same |
US7629333B2 (en) | 2002-03-29 | 2009-12-08 | Medimmune, Llc | Stable amorphous amifostine compositions and methods for the preparation and use of same |
-
1977
- 1977-09-21 JP JP11360177A patent/JPS6041676B2/en not_active Expired
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5591731A (en) * | 1992-07-31 | 1997-01-07 | U.S. Bioscience, Inc. | Crystalline amifostine compositions |
EP1243272A2 (en) | 1992-07-31 | 2002-09-25 | Medimmune Oncology, Inc. | Crystalline amifostine compositions and methods for the preparation and use of same |
EP1243272A3 (en) * | 1992-07-31 | 2003-01-22 | Medimmune Oncology, Inc. | Crystalline amifostine compositions and methods for the preparation and use of same |
EP1764103A3 (en) * | 1992-07-31 | 2011-08-24 | Medimmune Oncology, Inc. | Crystalline amifostine compositions and methods for the preparation and use of same |
US6384259B1 (en) | 1998-11-16 | 2002-05-07 | Medimmune Oncology, Inc. | Stable amorphous amifostine compositions and dosage form |
US6407278B2 (en) | 1998-11-16 | 2002-06-18 | Medimmune Oncology, Inc. | Stable amorphous amifostine compositions and methods for the preparation and use of the same |
US6841545B2 (en) | 1998-11-16 | 2005-01-11 | Medimmune Oncology, Inc. | Stable amorphous amifostine compositions and methods for the preparation of same |
US7629333B2 (en) | 2002-03-29 | 2009-12-08 | Medimmune, Llc | Stable amorphous amifostine compositions and methods for the preparation and use of same |
Also Published As
Publication number | Publication date |
---|---|
JPS6041676B2 (en) | 1985-09-18 |
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