JPS5576844A - Optical resolution of 1-phenylethylamine - Google Patents
Optical resolution of 1-phenylethylamineInfo
- Publication number
- JPS5576844A JPS5576844A JP14983978A JP14983978A JPS5576844A JP S5576844 A JPS5576844 A JP S5576844A JP 14983978 A JP14983978 A JP 14983978A JP 14983978 A JP14983978 A JP 14983978A JP S5576844 A JPS5576844 A JP S5576844A
- Authority
- JP
- Japan
- Prior art keywords
- phenylethylamine
- salt
- optically active
- resolution agent
- optical resolution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To perform optical resolution of 1-phenylethylamine useful as an optical resolution agent for racemic acids, etc. easily, in a high yield, by using cinnamic acid or cis-cyclohexane-1,2-dicarboxylic acid as a resolution agent in the selective crystallization method.
CONSTITUTION: In the optical resolution of 1-phenylethylamine, cinnamic acid or cis-cyclohexane-1,2-dicarboxylic acid is used as a resolution agent to give the salt of 1-phenylethylamine. The optically active acid salt is selectively crystallized from the salt solution. For example, the salt of the resolution agent and (±)-1-phenylethylamine which may contain an excess amount of one of the optically active isomers, is dissolved in a liquid diluent, e.g. methanol, etc., to a supersaturated state. A small amount of the crystal of the salt of the resolution agent and the optically active 1-phenylethylamine is added to the above solution as seed crystals, and the salt of an active isomer same as the optically active isomer seed crystals is separated by crystallization.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14983978A JPS5576844A (en) | 1978-12-04 | 1978-12-04 | Optical resolution of 1-phenylethylamine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14983978A JPS5576844A (en) | 1978-12-04 | 1978-12-04 | Optical resolution of 1-phenylethylamine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5576844A true JPS5576844A (en) | 1980-06-10 |
JPS5741457B2 JPS5741457B2 (en) | 1982-09-03 |
Family
ID=15483777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14983978A Granted JPS5576844A (en) | 1978-12-04 | 1978-12-04 | Optical resolution of 1-phenylethylamine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5576844A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5714561A (en) * | 1980-06-30 | 1982-01-25 | Hiroyuki Nohira | Optical resolution of 1-phenyl-2- p-tolyl ethylamine |
-
1978
- 1978-12-04 JP JP14983978A patent/JPS5576844A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5714561A (en) * | 1980-06-30 | 1982-01-25 | Hiroyuki Nohira | Optical resolution of 1-phenyl-2- p-tolyl ethylamine |
Also Published As
Publication number | Publication date |
---|---|
JPS5741457B2 (en) | 1982-09-03 |
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