JPS57136595A - Carcinostatic substance tf-230, its preparation, and carcinostatic agent containing the same - Google Patents
Carcinostatic substance tf-230, its preparation, and carcinostatic agent containing the sameInfo
- Publication number
- JPS57136595A JPS57136595A JP56022272A JP2227281A JPS57136595A JP S57136595 A JPS57136595 A JP S57136595A JP 56022272 A JP56022272 A JP 56022272A JP 2227281 A JP2227281 A JP 2227281A JP S57136595 A JPS57136595 A JP S57136595A
- Authority
- JP
- Japan
- Prior art keywords
- carcinostatic
- substance
- sulfuric acid
- exhibits
- culturing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Peptides Or Proteins (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
NEW MATERIAL:Light gray to light brown powder having the following characteristics; Active to suppress the proliferation of cancer cells such as Ehrlich ascites carcinoma of mouse; exhibits immuno-activating activity; insoluble in organic solvents such as methanol, acetone, benzene, etc.; exhibits no definite melting point and decomposes at 185W225°C; gives an ultraviolet absorption spectrum having peaks at 249W264nm, etc.; positive to Molish, phenol sulfuric acid, anthrone sulfuric acid, indole hydrochloric acid, and Lawry-Folin reaction; elemental analysis, C 42W45%, H 5W7% and N 10W11%; sugar content, 5W25%; protein content, 30W60%.
USE: Carcinostatic agent.
PROCESS: The carcinostatic substance TF-230 can be obtained by culturing bacteria capable of producing carcinostatic substance TF-230 and belonging to Fusobacterium genus, e.g. Fusobacterium nucleatum TF-031 (FERM-P No.5077), etc., adding hydrophilic organic solvent to the supernatant liquid of the culturing product, fractionating the produced precipitate with pH, and collecting the fraction preciptated between pH4 and 6.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56022272A JPS57136595A (en) | 1981-02-19 | 1981-02-19 | Carcinostatic substance tf-230, its preparation, and carcinostatic agent containing the same |
US06/347,871 US4477437A (en) | 1981-02-19 | 1982-02-11 | Substances having carcinostatic and immunostimulating activity |
DE19823205074 DE3205074A1 (en) | 1981-02-19 | 1982-02-12 | NEW CARCINOSTATIC AND IMMUNOSTIMULATING SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND CARCINOSTATIC AGENTS WITH A CONTENT THEREOF |
GB8204093A GB2093347B (en) | 1981-02-19 | 1982-02-12 | Immunostimulant material tf-2 from fusobacterium sp |
FI820527A FI69096C (en) | 1981-02-19 | 1982-02-17 | REFRIGERATION FOR CARCINOSTATICS AND IMMUNOSTIMULATION TF-2 SUBSTANCES |
FR8202601A FR2499855B1 (en) | 1981-02-19 | 1982-02-17 | NOVEL CARCINOSTATIC AND IMMUNO-STIMULATING SUBSTANCES, PROCESS FOR PREPARING SAME FROM FUSOBACTERIUM BACTERIA, AND CARCINOSTATIC AGENT CONTAINING SUCH SUBSTANCES |
DD82237480A DD202891A5 (en) | 1981-02-19 | 1982-02-17 | NEW CARCINOSTATIC AND IMMUNOSTIMULATING SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND CARCINOSTATIC AGENTS WITH A CONTENT OF THE SAME |
DK069282A DK151640C (en) | 1981-02-19 | 1982-02-17 | PROCEDURE FOR PREPARING RELATIONSHIPS WITH CARCINOSTATIC AND IMMUNOSTIMULATIVE EFFECT |
CH979/82A CH651052A5 (en) | 1981-02-19 | 1982-02-17 | METHOD FOR PRODUCING A CARCINOSTATIC SUBSTANCE AND CARCINOSTATIC SUBSTANCE. |
CA000396425A CA1184864A (en) | 1981-02-19 | 1982-02-17 | Substances having carcinostatic and immunostimulating activity, process for preparing the same and carcinostatic agent containing the same |
IT47817/82A IT1189224B (en) | 1981-02-19 | 1982-02-17 | CARCINOSTATIC AND IMMUNOSTIMULATING SUBSTANCES TF-2, PROCEDURE TO PREPARE THEM AND CARCINOSTATIC AGENT CONTAINING THEM |
NO820509A NO157426C (en) | 1981-02-19 | 1982-02-18 | PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE COMPOUNDS FOR THE CULTIVATION OF MICRO-ORGANISMS. |
KR8200714A KR890002256B1 (en) | 1981-02-19 | 1982-02-18 | Process for preparing anticanser tf-2 |
NL8200640A NL8200640A (en) | 1981-02-19 | 1982-02-18 | NEW CARCINOSTATIC SUBSTANCES, PREPARATIONS CONTAINING THEM AND METHOD FOR THE PREPARATION THEREOF. |
PT74455A PT74455B (en) | 1981-02-19 | 1982-02-18 | Process for preparing novel substances having carcinostatic and immunostimulating activity and of a carcinostatic agent containing same |
NZ199771A NZ199771A (en) | 1981-02-19 | 1982-02-18 | Carcinostatic and immunostimulating substances produced by fusobacterium nucleatum |
SE8201016A SE457000B (en) | 1981-02-19 | 1982-02-18 | PROCEDURE FOR PREPARING A CARCINOSTATIC AND IMMUNOSTIMULATING TF-2 SUBSTANCE, CARCINOSTATIC TF-2 SUBSTANCE AND CARCINOSTATIC AGENT. |
ES509774A ES8308926A1 (en) | 1981-02-19 | 1982-02-19 | Immunostimulant, carcinostatics TF-2 by cultivation of fusobacterium |
BE0/207355A BE892204A (en) | 1981-02-19 | 1982-02-19 | NOVEL CARCINOSTATIC AND IMMUNQ-STIMULATING SUBSTANCES, PROCESS FOR PREPARING THEM FROM FUSOBACTERIUM BACTERIA, AND CARCINOSTATIC AGENT CONTAINING SUCH SUBSTANCES |
AT0064682A AT381722B (en) | 1981-02-19 | 1982-02-19 | METHOD FOR PRODUCING A NEW CARCINOSTATIC SUBSTANCE |
US06/619,895 US4591558A (en) | 1981-02-19 | 1984-08-06 | Novel substances having antitumor and immunostimulating activity, process for preparing the same and antitumor agent containing the same |
DK251186A DK165641C (en) | 1981-02-19 | 1986-05-29 | PROCEDURE FOR PREPARING TF-220, TF-230 AND TF-240 COMPOUNDS AND THE SIMILAR PROTEIN-FREE COMPOUNDS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56022272A JPS57136595A (en) | 1981-02-19 | 1981-02-19 | Carcinostatic substance tf-230, its preparation, and carcinostatic agent containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57136595A true JPS57136595A (en) | 1982-08-23 |
JPH021153B2 JPH021153B2 (en) | 1990-01-10 |
Family
ID=12078121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56022272A Granted JPS57136595A (en) | 1981-02-19 | 1981-02-19 | Carcinostatic substance tf-230, its preparation, and carcinostatic agent containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57136595A (en) |
-
1981
- 1981-02-19 JP JP56022272A patent/JPS57136595A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPH021153B2 (en) | 1990-01-10 |
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