IT1189224B - CARCINOSTATIC AND IMMUNOSTIMULATING SUBSTANCES TF-2, PROCEDURE TO PREPARE THEM AND CARCINOSTATIC AGENT CONTAINING THEM - Google Patents
CARCINOSTATIC AND IMMUNOSTIMULATING SUBSTANCES TF-2, PROCEDURE TO PREPARE THEM AND CARCINOSTATIC AGENT CONTAINING THEMInfo
- Publication number
- IT1189224B IT1189224B IT47817/82A IT4781782A IT1189224B IT 1189224 B IT1189224 B IT 1189224B IT 47817/82 A IT47817/82 A IT 47817/82A IT 4781782 A IT4781782 A IT 4781782A IT 1189224 B IT1189224 B IT 1189224B
- Authority
- IT
- Italy
- Prior art keywords
- carcinostatic
- substances
- agent containing
- prepare
- procedure
- Prior art date
Links
- 239000000126 substance Substances 0.000 title abstract 4
- 101000651310 Desulfitobacterium hafniense (strain Y51) Trigger factor 2 Proteins 0.000 title abstract 2
- 230000003308 immunostimulating effect Effects 0.000 title abstract 2
- 230000003327 cancerostatic effect Effects 0.000 title 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000605909 Fusobacterium Species 0.000 abstract 1
- 241000282414 Homo sapiens Species 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/05—Immunological preparations stimulating the reticulo-endothelial system, e.g. against cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
Abstract
Novel TF-2 substances having antitumor and immunostimulating activity, which are obtained from a culture or its supernatant fluid prepared by culturing bacteria belonging to Fusobacterium genus. Said substances are useful for the treatment of cancerous diseases of the mammals including human beings. This disclosure concerns such substances and a process for preparing the same and an antitumor agent containing the same.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56022270A JPS57136593A (en) | 1981-02-19 | 1981-02-19 | Carcinostatic substance tf-210, its preparation, and carcinostatic agent containing the same |
JP56022275A JPS57136598A (en) | 1981-02-19 | 1981-02-19 | Carcinostatic substance tf-300, its preparation, and carcinostatic agent containing the same |
JP56022273A JPS57136596A (en) | 1981-02-19 | 1981-02-19 | Carcinostatic substance tf-240, its preparation, and carcinostatic agent containing the same |
JP56022277A JPS57139089A (en) | 1981-02-19 | 1981-02-19 | Carcinostatic substance tf-350, its preparation and carcinostatic agent containing the same |
JP56022271A JPS57136594A (en) | 1981-02-19 | 1981-02-19 | Carcinostatic substance tf-220, its preparation, and carcinostatic agent containing the same |
JP56022274A JPS57136597A (en) | 1981-02-19 | 1981-02-19 | Carcinostatic substance tf-250, its preparation, and carcinostatic agent containing the same |
JP56022276A JPS57139088A (en) | 1981-02-19 | 1981-02-19 | Carcinostatic substance tf-340, its preparation and carcinostatic agent containing the same |
JP56022272A JPS57136595A (en) | 1981-02-19 | 1981-02-19 | Carcinostatic substance tf-230, its preparation, and carcinostatic agent containing the same |
JP57011744A JPS58129977A (en) | 1982-01-29 | 1982-01-29 | Carcinostatic substance tf-300-2, its preparation and carcinostatic agent containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8247817A0 IT8247817A0 (en) | 1982-02-17 |
IT1189224B true IT1189224B (en) | 1988-01-28 |
Family
ID=27576620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT47817/82A IT1189224B (en) | 1981-02-19 | 1982-02-17 | CARCINOSTATIC AND IMMUNOSTIMULATING SUBSTANCES TF-2, PROCEDURE TO PREPARE THEM AND CARCINOSTATIC AGENT CONTAINING THEM |
Country Status (16)
Country | Link |
---|---|
US (1) | US4591558A (en) |
AT (1) | AT381722B (en) |
BE (1) | BE892204A (en) |
CA (1) | CA1184864A (en) |
CH (1) | CH651052A5 (en) |
DE (1) | DE3205074A1 (en) |
DK (1) | DK151640C (en) |
FI (1) | FI69096C (en) |
FR (1) | FR2499855B1 (en) |
GB (1) | GB2093347B (en) |
IT (1) | IT1189224B (en) |
NL (1) | NL8200640A (en) |
NO (1) | NO157426C (en) |
NZ (1) | NZ199771A (en) |
PT (1) | PT74455B (en) |
SE (1) | SE457000B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5931715A (en) * | 1982-08-17 | 1984-02-20 | Toyama Chem Co Ltd | Preparation of carcinostatic substance tf-500 |
WO2010096668A1 (en) * | 2009-02-20 | 2010-08-26 | Frymaster L.L.C. | Racking system for deep fryer |
CN102595987A (en) | 2009-07-15 | 2012-07-18 | 弗瑞马斯特公司 | Automated rack/basket lifting system for deep open vat frying system |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5461112A (en) * | 1977-10-24 | 1979-05-17 | Ono Pharmaceut Co Ltd | Oncostatic polysaccharide* its preparation* and oncostatic drugs containing it as an effective component |
JPS5943929B2 (en) * | 1979-08-13 | 1984-10-25 | サッポロビール株式会社 | Polysaccharide RBS substance, its production method, and antitumor agent containing it as an active ingredient |
DE3031152A1 (en) * | 1979-08-24 | 1981-03-19 | Toyama Chemical Co. Ltd., Tokyo | CARCINOSTATIC SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND MEDIUM WITH A CONTENT THEREOF |
US4477437A (en) * | 1981-02-19 | 1984-10-16 | Toyama Chemical Co., Ltd. | Substances having carcinostatic and immunostimulating activity |
-
1982
- 1982-02-12 DE DE19823205074 patent/DE3205074A1/en active Granted
- 1982-02-12 GB GB8204093A patent/GB2093347B/en not_active Expired
- 1982-02-17 CH CH979/82A patent/CH651052A5/en not_active IP Right Cessation
- 1982-02-17 IT IT47817/82A patent/IT1189224B/en active
- 1982-02-17 DK DK069282A patent/DK151640C/en not_active IP Right Cessation
- 1982-02-17 FR FR8202601A patent/FR2499855B1/en not_active Expired
- 1982-02-17 CA CA000396425A patent/CA1184864A/en not_active Expired
- 1982-02-17 FI FI820527A patent/FI69096C/en not_active IP Right Cessation
- 1982-02-18 PT PT74455A patent/PT74455B/en not_active IP Right Cessation
- 1982-02-18 NO NO820509A patent/NO157426C/en unknown
- 1982-02-18 NZ NZ199771A patent/NZ199771A/en unknown
- 1982-02-18 SE SE8201016A patent/SE457000B/en unknown
- 1982-02-18 NL NL8200640A patent/NL8200640A/en not_active Application Discontinuation
- 1982-02-19 AT AT0064682A patent/AT381722B/en not_active IP Right Cessation
- 1982-02-19 BE BE0/207355A patent/BE892204A/en not_active IP Right Cessation
-
1984
- 1984-08-06 US US06/619,895 patent/US4591558A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AT381722B (en) | 1986-11-25 |
NO157426C (en) | 1988-03-16 |
DE3205074C2 (en) | 1987-09-24 |
CH651052A5 (en) | 1985-08-30 |
FI820527L (en) | 1982-08-20 |
DK151640C (en) | 1988-06-20 |
SE8201016L (en) | 1982-08-20 |
PT74455B (en) | 1984-12-04 |
FR2499855B1 (en) | 1985-07-12 |
SE457000B (en) | 1988-11-21 |
US4591558A (en) | 1986-05-27 |
NL8200640A (en) | 1982-09-16 |
NZ199771A (en) | 1985-09-13 |
DE3205074A1 (en) | 1982-12-16 |
FI69096C (en) | 1985-12-10 |
CA1184864A (en) | 1985-04-02 |
PT74455A (en) | 1982-03-01 |
NO157426B (en) | 1987-12-07 |
GB2093347A (en) | 1982-09-02 |
FR2499855A1 (en) | 1982-08-20 |
DK69282A (en) | 1982-08-20 |
ATA64682A (en) | 1986-04-15 |
IT8247817A0 (en) | 1982-02-17 |
GB2093347B (en) | 1985-03-27 |
DK151640B (en) | 1987-12-21 |
FI69096B (en) | 1985-08-30 |
NO820509L (en) | 1982-08-20 |
BE892204A (en) | 1982-08-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950125 |