JPS57134417A - Cardiotonic agent - Google Patents
Cardiotonic agentInfo
- Publication number
- JPS57134417A JPS57134417A JP56020490A JP2049081A JPS57134417A JP S57134417 A JPS57134417 A JP S57134417A JP 56020490 A JP56020490 A JP 56020490A JP 2049081 A JP2049081 A JP 2049081A JP S57134417 A JPS57134417 A JP S57134417A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- agent
- phenylthiazole
- phenylacetaldehyde
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000496 cardiotonic agent Substances 0.000 title abstract 2
- ZLLOWHFKKIOINR-UHFFFAOYSA-N 5-phenyl-1,3-thiazole Chemical class S1C=NC=C1C1=CC=CC=C1 ZLLOWHFKKIOINR-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- DTUQWGWMVIHBKE-UHFFFAOYSA-N phenylacetaldehyde Chemical compound O=CCC1=CC=CC=C1 DTUQWGWMVIHBKE-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- LOUZEJGRHQDABV-UHFFFAOYSA-N 2-bromo-2-phenylacetaldehyde Chemical compound O=CC(Br)C1=CC=CC=C1 LOUZEJGRHQDABV-UHFFFAOYSA-N 0.000 abstract 1
- JGLDQLVRYJRBBW-UHFFFAOYSA-N 5-phenyl-3h-1,3-thiazol-2-one Chemical compound S1C(O)=NC=C1C1=CC=CC=C1 JGLDQLVRYJRBBW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001746 atrial effect Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- CYEBJEDOHLIWNP-UHFFFAOYSA-N methanethioamide Chemical compound NC=S CYEBJEDOHLIWNP-UHFFFAOYSA-N 0.000 abstract 1
- 229940100595 phenylacetaldehyde Drugs 0.000 abstract 1
- 230000033764 rhythmic process Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
- YUKQRDCYNOVPGJ-UHFFFAOYSA-N thioacetamide Chemical compound CC(N)=S YUKQRDCYNOVPGJ-UHFFFAOYSA-N 0.000 abstract 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56020490A JPS57134417A (en) | 1981-02-14 | 1981-02-14 | Cardiotonic agent |
| US06/345,672 US4418070A (en) | 1981-02-14 | 1982-02-04 | Cardiotonic agents |
| FR8202257A FR2499853B1 (fr) | 1981-02-14 | 1982-02-11 | Agents cardiotoniques, a base de derives du 5-phenylthiazole et composition pharmaceutique contenant un tel agent |
| DE19823204732 DE3204732A1 (de) | 1981-02-14 | 1982-02-11 | Herztonikum |
| IT19647/82A IT1157267B (it) | 1981-02-14 | 1982-02-12 | Agente cardiostimolante oppure cardiotonico |
| GB8204233A GB2094143B (en) | 1981-02-14 | 1982-02-12 | Compositions containing 5-phenylthiazoles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56020490A JPS57134417A (en) | 1981-02-14 | 1981-02-14 | Cardiotonic agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57134417A true JPS57134417A (en) | 1982-08-19 |
| JPH024577B2 JPH024577B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-01-29 |
Family
ID=12028583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56020490A Granted JPS57134417A (en) | 1981-02-14 | 1981-02-14 | Cardiotonic agent |
Country Status (6)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6043373A (en) * | 1995-07-12 | 2000-03-28 | Yungjin Pharmaceutical Co., Ltd. | Heterocycle-fused thiazole derivatives |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4721721A (en) * | 1984-12-18 | 1988-01-26 | Rorer Pharmaceutical Corporation | 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses |
| US4734422A (en) * | 1985-10-15 | 1988-03-29 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic aroylthiazolones and the use thereof |
| US4670450A (en) * | 1985-11-13 | 1987-06-02 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic thiazolones |
| US4666913A (en) * | 1985-11-22 | 1987-05-19 | William H. Rorer, Inc. | Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses |
| DE102010045797A1 (de) * | 2010-09-20 | 2012-03-22 | Klinikum Darmstadt Gmbh | Verbindungen für die Diagnostik neurodegenerativer Erkrankungen am Riechepithel |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2132431A1 (de) * | 1971-06-30 | 1973-01-11 | Riedel De Haen Ag | 4-phenyl-thiazolderivate enthaltende pharmazeutische praeparate |
| BE790569A (fr) * | 1971-10-27 | 1973-04-26 | Syntex Corp | Agents cardiovasculaires a base de thiazoles |
-
1981
- 1981-02-14 JP JP56020490A patent/JPS57134417A/ja active Granted
-
1982
- 1982-02-04 US US06/345,672 patent/US4418070A/en not_active Expired - Fee Related
- 1982-02-11 FR FR8202257A patent/FR2499853B1/fr not_active Expired
- 1982-02-11 DE DE19823204732 patent/DE3204732A1/de active Granted
- 1982-02-12 IT IT19647/82A patent/IT1157267B/it active
- 1982-02-12 GB GB8204233A patent/GB2094143B/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6043373A (en) * | 1995-07-12 | 2000-03-28 | Yungjin Pharmaceutical Co., Ltd. | Heterocycle-fused thiazole derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2499853B1 (fr) | 1985-11-22 |
| FR2499853A1 (fr) | 1982-08-20 |
| US4418070A (en) | 1983-11-29 |
| GB2094143A (en) | 1982-09-15 |
| DE3204732A1 (de) | 1982-09-09 |
| GB2094143B (en) | 1984-12-19 |
| DE3204732C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1991-04-11 |
| IT1157267B (it) | 1987-02-11 |
| JPH024577B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-01-29 |
| IT8219647A0 (it) | 1982-02-12 |
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