JPS5690052A - Preparation of 4-hydroxybenzyl nitrile derivative - Google Patents
Preparation of 4-hydroxybenzyl nitrile derivativeInfo
- Publication number
- JPS5690052A JPS5690052A JP16354679A JP16354679A JPS5690052A JP S5690052 A JPS5690052 A JP S5690052A JP 16354679 A JP16354679 A JP 16354679A JP 16354679 A JP16354679 A JP 16354679A JP S5690052 A JPS5690052 A JP S5690052A
- Authority
- JP
- Japan
- Prior art keywords
- raw material
- hydroxybenzyl
- agent
- ester derivative
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled compound which is an intermediate for a β-blocker (a cardiac drug) and an anti-inflammatory agent in a short step simply, by reacting an industrially and readily available 4-haloalkylphenol ester derivative as a raw material with a cyanogenating agent.
CONSTITUTION: A 4-haloalkylphenol ester derivative expressed by formula III (R is lower alkyl or aryl; R1 is H halogen or alkoxyl; R2 is H, lower alkyl or aryl; X is halogen) as a raw material is reacted with a cyanogenating agent, e.g. potassium cyanide, to give a 4-hydroxybenzyl nitrile derivative of formula I. The raw material is obtained by reacting a 4-alkylphenol ester derivative expressed by formula II with a halogenating agent.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16354679A JPS5690052A (en) | 1979-12-18 | 1979-12-18 | Preparation of 4-hydroxybenzyl nitrile derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16354679A JPS5690052A (en) | 1979-12-18 | 1979-12-18 | Preparation of 4-hydroxybenzyl nitrile derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5690052A true JPS5690052A (en) | 1981-07-21 |
JPS6147824B2 JPS6147824B2 (en) | 1986-10-21 |
Family
ID=15775940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16354679A Granted JPS5690052A (en) | 1979-12-18 | 1979-12-18 | Preparation of 4-hydroxybenzyl nitrile derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5690052A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5176234A (en) * | 1974-12-03 | 1976-07-01 | Bayer Ag |
-
1979
- 1979-12-18 JP JP16354679A patent/JPS5690052A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5176234A (en) * | 1974-12-03 | 1976-07-01 | Bayer Ag |
Also Published As
Publication number | Publication date |
---|---|
JPS6147824B2 (en) | 1986-10-21 |
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