JPS5767599A - Preparation of 5-beta-choleic acid derivative - Google Patents

Preparation of 5-beta-choleic acid derivative

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Publication number
JPS5767599A
JPS5767599A JP14156180A JP14156180A JPS5767599A JP S5767599 A JPS5767599 A JP S5767599A JP 14156180 A JP14156180 A JP 14156180A JP 14156180 A JP14156180 A JP 14156180A JP S5767599 A JPS5767599 A JP S5767599A
Authority
JP
Japan
Prior art keywords
ester
diacyloxy
hydroxy
cholanic
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14156180A
Other languages
Japanese (ja)
Inventor
Masahiro Yasaka
Takeshi Hiiro
Mutsuo Ishii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kawaken Fine Chemicals Co Ltd
Original Assignee
Kawaken Fine Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kawaken Fine Chemicals Co Ltd filed Critical Kawaken Fine Chemicals Co Ltd
Priority to JP14156180A priority Critical patent/JPS5767599A/en
Publication of JPS5767599A publication Critical patent/JPS5767599A/en
Pending legal-status Critical Current

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Abstract

PURPOSE: To obtain the titled compound useful as an intermediate for synthesizing a solubilizer for gallstone industrially advantageously, by reacting a diacyloxy-hydroxy-cholanic ester with phosphorus trichloride in the presence of a tertiary amine.
CONSTITUTION: A 3α,7α-diacyloxy-12-hydroxy-5β-cholanic ester (e.g., 3α,7α-diacetoxy-12-hydroxy-5β-cholanic acid methyl ester. etc.) shown by the formulaI(R is lower alkyl; X is acyl) is reacted with phosphorus trichloride in a molar amount preferably 1W1.2 times as much as that of the compound in the presence of a tertiary amine (preferably α-picoline, etc.) occasionally in an inert solvent, e.g., dichloroethane, etc. at 120W150°C, to give the desired 3α,7α-diacyloxy-5β-11-choleic ester shown by the formula II.
EFFECT: By-products, e.g., compounds related to hydrazine are not prepared.
COPYRIGHT: (C)1982,JPO&Japio
JP14156180A 1980-10-09 1980-10-09 Preparation of 5-beta-choleic acid derivative Pending JPS5767599A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14156180A JPS5767599A (en) 1980-10-09 1980-10-09 Preparation of 5-beta-choleic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14156180A JPS5767599A (en) 1980-10-09 1980-10-09 Preparation of 5-beta-choleic acid derivative

Publications (1)

Publication Number Publication Date
JPS5767599A true JPS5767599A (en) 1982-04-24

Family

ID=15294824

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14156180A Pending JPS5767599A (en) 1980-10-09 1980-10-09 Preparation of 5-beta-choleic acid derivative

Country Status (1)

Country Link
JP (1) JPS5767599A (en)

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