JPS5677298A - Movel 5-fluorouridine derivative and its preparation - Google Patents
Movel 5-fluorouridine derivative and its preparationInfo
- Publication number
- JPS5677298A JPS5677298A JP15292279A JP15292279A JPS5677298A JP S5677298 A JPS5677298 A JP S5677298A JP 15292279 A JP15292279 A JP 15292279A JP 15292279 A JP15292279 A JP 15292279A JP S5677298 A JPS5677298 A JP S5677298A
- Authority
- JP
- Japan
- Prior art keywords
- fluorouridine
- movel
- preparation
- acyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FHIDNBAQOFJWCA-UAKXSSHOSA-N 5-fluorouridine Chemical class O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 FHIDNBAQOFJWCA-UAKXSSHOSA-N 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- -1 e.g. Substances 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- ZCGHCZMVDSJOFI-SEFVSHJNSA-N [(2r,3s,4r,5r)-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2s)-4-methylsulfanyl-2-(phenylmethoxycarbonylamino)butanoate Chemical compound N([C@@H](CCSC)C(=O)OC[C@@H]1[C@H]([C@@H](O)[C@@H](O1)N1C(NC(=O)C(F)=C1)=O)O)C(=O)OCC1=CC=CC=C1 ZCGHCZMVDSJOFI-SEFVSHJNSA-N 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 230000009876 antimalignant effect Effects 0.000 abstract 1
- 150000007514 bases Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000005270 trialkylamine group Chemical group 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15292279A JPS5677298A (en) | 1979-11-28 | 1979-11-28 | Movel 5-fluorouridine derivative and its preparation |
| US06/210,796 US4340728A (en) | 1979-11-28 | 1980-11-26 | Nucleoside derivatives and process for preparing same |
| DE19803044740 DE3044740A1 (de) | 1979-11-28 | 1980-11-27 | Nucleosidderivate, ihre herstellung und pharmazeutische mittel |
| IT26289/80A IT1141100B (it) | 1979-11-28 | 1980-11-27 | Derivati nucleosidici e processo per la loro preparazione |
| GB8038211A GB2066812B (en) | 1979-11-28 | 1980-11-28 | 5'-acyl-uridine derivatives and processes for the preparation thereof |
| CH883380A CH646441A5 (de) | 1979-11-28 | 1980-11-28 | Nucleosidderivate, ihre herstellung und diese enthaltende pharmazeutische mittel. |
| FR8025348A FR2470774A1 (fr) | 1979-11-28 | 1980-11-28 | Derives de nucleosides, leur preparation et leurs utilisations therapeutiques |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15292279A JPS5677298A (en) | 1979-11-28 | 1979-11-28 | Movel 5-fluorouridine derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5677298A true JPS5677298A (en) | 1981-06-25 |
| JPS621399B2 JPS621399B2 (enrdf_load_stackoverflow) | 1987-01-13 |
Family
ID=15551073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15292279A Granted JPS5677298A (en) | 1979-11-28 | 1979-11-28 | Movel 5-fluorouridine derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5677298A (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61134397A (ja) * | 1984-12-01 | 1986-06-21 | Fuji Kagaku Kogyo Kk | ５’−０−オリゴペプチジル−５−フルオロウリジン及びその製造方法 |
| WO1988003146A1 (en) * | 1985-04-22 | 1988-05-05 | Fuji Kagaku Kogyo Kabushiki Kaisha | Novel 5'-o-acyl-5-fluorouridines and process for their preparation |
| US4892939A (en) * | 1986-05-30 | 1990-01-09 | Fuji Kagaku Kogyo Kabushiki Kaisha | Oligopeptidyl-5-fluorouridine compounds and process for preparing the same |
-
1979
- 1979-11-28 JP JP15292279A patent/JPS5677298A/ja active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61134397A (ja) * | 1984-12-01 | 1986-06-21 | Fuji Kagaku Kogyo Kk | ５’−０−オリゴペプチジル−５−フルオロウリジン及びその製造方法 |
| WO1988003146A1 (en) * | 1985-04-22 | 1988-05-05 | Fuji Kagaku Kogyo Kabushiki Kaisha | Novel 5'-o-acyl-5-fluorouridines and process for their preparation |
| US4892939A (en) * | 1986-05-30 | 1990-01-09 | Fuji Kagaku Kogyo Kabushiki Kaisha | Oligopeptidyl-5-fluorouridine compounds and process for preparing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS621399B2 (enrdf_load_stackoverflow) | 1987-01-13 |
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