JPS5653670A - 2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component - Google Patents
2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective componentInfo
- Publication number
- JPS5653670A JPS5653670A JP12882679A JP12882679A JPS5653670A JP S5653670 A JPS5653670 A JP S5653670A JP 12882679 A JP12882679 A JP 12882679A JP 12882679 A JP12882679 A JP 12882679A JP S5653670 A JPS5653670 A JP S5653670A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- carboxylic acid
- oxothiazolidine
- acid derivative
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A 2-oxothazolidine-4-carboxylic acid derivative formula I (R1 is H, lower alkanoyl or benzoyl; R and R2 are H or alkyl) or when R is H, a nontoxic salt of the acid.
EXAMPLE: 3-[3-Acetylthio-2(S)-methylpropanoyl]-2-oxothiazolidine-4(R)-carboxylic acid tert-butyl ester.
USE: Hypotensor having angiotensinase inhibiting activity. Does: 1W50mg/kg wt. daily for oral administration, and 0.1W10mg/kg wt. daily for parenteral administration. Administered 2W4 times daily.
PROCESS: A compound of formula I wherein R is R3 and R1 is R4, can be prepared by reacting a compound of formula II (R3 is lower alkyl; M is alkali metal) with a compound of formula III (R4 is lower alkanoyl or benzoyl) in an inert organic solvent at room temperature.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12882679A JPS5653670A (en) | 1979-10-08 | 1979-10-08 | 2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component |
FR8009787A FR2455585A1 (en) | 1979-05-04 | 1980-04-30 | OXOAMINOACID DERIVATIVES, MANUFACTURING METHOD AND PHARMACEUTICAL COMPOSITION |
GB8014359A GB2051781B (en) | 1979-05-04 | 1980-05-01 | Oxoamino acid derivatives |
DE19803016960 DE3016960A1 (en) | 1979-05-04 | 1980-05-02 | OXOAMINOAID DERIVATIVES AND THEIR NON-TOXIC SALTS, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
IT8048579A IT8048579A0 (en) | 1979-05-04 | 1980-05-05 | OXOAMINO ACIDS DERIVATIVES PROCEDURE FOR PRODUCING THEM AND COMPOSITIONS CONTAINING THEM |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12882679A JPS5653670A (en) | 1979-10-08 | 1979-10-08 | 2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5653670A true JPS5653670A (en) | 1981-05-13 |
Family
ID=14994360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12882679A Pending JPS5653670A (en) | 1979-05-04 | 1979-10-08 | 2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5653670A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60157562A (en) * | 1984-12-14 | 1985-08-17 | Toyota Motor Corp | Automatic transmission |
-
1979
- 1979-10-08 JP JP12882679A patent/JPS5653670A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60157562A (en) * | 1984-12-14 | 1985-08-17 | Toyota Motor Corp | Automatic transmission |
JPS6242184B2 (en) * | 1984-12-14 | 1987-09-07 | Toyota Motor Co Ltd |
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