JPS5653670A - 2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component - Google Patents

2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component

Info

Publication number
JPS5653670A
JPS5653670A JP12882679A JP12882679A JPS5653670A JP S5653670 A JPS5653670 A JP S5653670A JP 12882679 A JP12882679 A JP 12882679A JP 12882679 A JP12882679 A JP 12882679A JP S5653670 A JPS5653670 A JP S5653670A
Authority
JP
Japan
Prior art keywords
compound
carboxylic acid
oxothiazolidine
acid derivative
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12882679A
Other languages
Japanese (ja)
Inventor
Masaaki Toda
Katsuhiro Imaki
Shigeru Sakuyama
Tadanori Okada
Masaki Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP12882679A priority Critical patent/JPS5653670A/en
Priority to FR8009787A priority patent/FR2455585A1/en
Priority to GB8014359A priority patent/GB2051781B/en
Priority to DE19803016960 priority patent/DE3016960A1/en
Priority to IT8048579A priority patent/IT8048579A0/en
Publication of JPS5653670A publication Critical patent/JPS5653670A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A 2-oxothazolidine-4-carboxylic acid derivative formula I (R1 is H, lower alkanoyl or benzoyl; R and R2 are H or alkyl) or when R is H, a nontoxic salt of the acid.
EXAMPLE: 3-[3-Acetylthio-2(S)-methylpropanoyl]-2-oxothiazolidine-4(R)-carboxylic acid tert-butyl ester.
USE: Hypotensor having angiotensinase inhibiting activity. Does: 1W50mg/kg wt. daily for oral administration, and 0.1W10mg/kg wt. daily for parenteral administration. Administered 2W4 times daily.
PROCESS: A compound of formula I wherein R is R3 and R1 is R4, can be prepared by reacting a compound of formula II (R3 is lower alkyl; M is alkali metal) with a compound of formula III (R4 is lower alkanoyl or benzoyl) in an inert organic solvent at room temperature.
COPYRIGHT: (C)1981,JPO&Japio
JP12882679A 1979-05-04 1979-10-08 2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component Pending JPS5653670A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP12882679A JPS5653670A (en) 1979-10-08 1979-10-08 2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component
FR8009787A FR2455585A1 (en) 1979-05-04 1980-04-30 OXOAMINOACID DERIVATIVES, MANUFACTURING METHOD AND PHARMACEUTICAL COMPOSITION
GB8014359A GB2051781B (en) 1979-05-04 1980-05-01 Oxoamino acid derivatives
DE19803016960 DE3016960A1 (en) 1979-05-04 1980-05-02 OXOAMINOAID DERIVATIVES AND THEIR NON-TOXIC SALTS, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
IT8048579A IT8048579A0 (en) 1979-05-04 1980-05-05 OXOAMINO ACIDS DERIVATIVES PROCEDURE FOR PRODUCING THEM AND COMPOSITIONS CONTAINING THEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12882679A JPS5653670A (en) 1979-10-08 1979-10-08 2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component

Publications (1)

Publication Number Publication Date
JPS5653670A true JPS5653670A (en) 1981-05-13

Family

ID=14994360

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12882679A Pending JPS5653670A (en) 1979-05-04 1979-10-08 2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component

Country Status (1)

Country Link
JP (1) JPS5653670A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60157562A (en) * 1984-12-14 1985-08-17 Toyota Motor Corp Automatic transmission

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60157562A (en) * 1984-12-14 1985-08-17 Toyota Motor Corp Automatic transmission
JPS6242184B2 (en) * 1984-12-14 1987-09-07 Toyota Motor Co Ltd

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