JPS5653670A - 2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component - Google Patents
2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective componentInfo
- Publication number
- JPS5653670A JPS5653670A JP12882679A JP12882679A JPS5653670A JP S5653670 A JPS5653670 A JP S5653670A JP 12882679 A JP12882679 A JP 12882679A JP 12882679 A JP12882679 A JP 12882679A JP S5653670 A JPS5653670 A JP S5653670A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- carboxylic acid
- oxothiazolidine
- acid derivative
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- BMLMGCPTLHPWPY-UHFFFAOYSA-N 2-oxo-1,3-thiazolidine-4-carboxylic acid Chemical class OC(=O)C1CSC(=O)N1 BMLMGCPTLHPWPY-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- -1 3-[3-Acetylthio-2(S)-methylpropanoyl]-2-oxothiazolidine-4(R)-carboxylic acid tert-butyl ester Chemical compound 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical group 0.000 abstract 1
- 108010058865 angiotensinase Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 2-oxothazolidine-4-carboxylic acid derivative formula I (R1 is H, lower alkanoyl or benzoyl; R and R2 are H or alkyl) or when R is H, a nontoxic salt of the acid.
EXAMPLE: 3-[3-Acetylthio-2(S)-methylpropanoyl]-2-oxothiazolidine-4(R)-carboxylic acid tert-butyl ester.
USE: Hypotensor having angiotensinase inhibiting activity. Does: 1W50mg/kg wt. daily for oral administration, and 0.1W10mg/kg wt. daily for parenteral administration. Administered 2W4 times daily.
PROCESS: A compound of formula I wherein R is R3 and R1 is R4, can be prepared by reacting a compound of formula II (R3 is lower alkyl; M is alkali metal) with a compound of formula III (R4 is lower alkanoyl or benzoyl) in an inert organic solvent at room temperature.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12882679A JPS5653670A (en) | 1979-10-08 | 1979-10-08 | 2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component |
| FR8009787A FR2455585A1 (en) | 1979-05-04 | 1980-04-30 | OXOAMINOACID DERIVATIVES, MANUFACTURING METHOD AND PHARMACEUTICAL COMPOSITION |
| GB8014359A GB2051781B (en) | 1979-05-04 | 1980-05-01 | Oxoamino acid derivatives |
| DE19803016960 DE3016960A1 (en) | 1979-05-04 | 1980-05-02 | OXOAMINOAID DERIVATIVES AND THEIR NON-TOXIC SALTS, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
| IT8048579A IT8048579A0 (en) | 1979-05-04 | 1980-05-05 | OXOAMINO ACIDS DERIVATIVES PROCEDURE FOR PRODUCING THEM AND COMPOSITIONS CONTAINING THEM |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12882679A JPS5653670A (en) | 1979-10-08 | 1979-10-08 | 2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5653670A true JPS5653670A (en) | 1981-05-13 |
Family
ID=14994360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12882679A Pending JPS5653670A (en) | 1979-05-04 | 1979-10-08 | 2-oxothiazolidine-4-carboxylic acid derivative, its preparation, and pharmaceutical composition containing said compound as effective component |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5653670A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60157562A (en) * | 1984-12-14 | 1985-08-17 | Toyota Motor Corp | automatic transmission |
-
1979
- 1979-10-08 JP JP12882679A patent/JPS5653670A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60157562A (en) * | 1984-12-14 | 1985-08-17 | Toyota Motor Corp | automatic transmission |
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