JPS56500254A - - Google Patents

Info

Publication number
JPS56500254A
JPS56500254A JP50062580A JP50062580A JPS56500254A JP S56500254 A JPS56500254 A JP S56500254A JP 50062580 A JP50062580 A JP 50062580A JP 50062580 A JP50062580 A JP 50062580A JP S56500254 A JPS56500254 A JP S56500254A
Authority
JP
Japan
Prior art keywords
prostaglandin
residues
linked
molecular weight
average molecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP50062580A
Other languages
English (en)
Other versions
JPH0323530B2 (ja
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of JPS56500254A publication Critical patent/JPS56500254A/ja
Publication of JPH0323530B2 publication Critical patent/JPH0323530B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/65—Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
    • C08G18/66—Compounds of groups C08G18/42, C08G18/48, or C08G18/52
    • C08G18/6666—Compounds of group C08G18/48 or C08G18/52
    • C08G18/667—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38
    • C08G18/6674—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203
    • C08G18/6677—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203 having at least three hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2210/00—Compositions for preparing hydrogels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2250/00—Compositions for preparing crystalline polymers
JP55500625A 1979-03-21 1980-03-21 Expired - Lifetime JPH0323530B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7909853 1979-03-21

Publications (2)

Publication Number Publication Date
JPS56500254A true JPS56500254A (ja) 1981-03-05
JPH0323530B2 JPH0323530B2 (ja) 1991-03-29

Family

ID=10504015

Family Applications (2)

Application Number Title Priority Date Filing Date
JP55500624A Expired - Lifetime JPH0323529B2 (ja) 1979-03-21 1980-03-21
JP55500625A Expired - Lifetime JPH0323530B2 (ja) 1979-03-21 1980-03-21

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP55500624A Expired - Lifetime JPH0323529B2 (ja) 1979-03-21 1980-03-21

Country Status (11)

Country Link
US (2) US4931288A (ja)
EP (2) EP0016654B1 (ja)
JP (2) JPH0323529B2 (ja)
AT (2) ATE15444T1 (ja)
AU (2) AU537741B2 (ja)
DE (2) DE3071006D1 (ja)
GB (2) GB2047094B (ja)
HK (2) HK79885A (ja)
NZ (2) NZ193221A (ja)
WO (2) WO1980001984A1 (ja)
ZA (2) ZA801659B (ja)

Families Citing this family (68)

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US5079009A (en) * 1979-03-21 1992-01-07 National Research Development Corporation Controlled release compositions including polyethylene oxide with urethane cross-linking
NZ197543A (en) * 1980-07-02 1984-12-14 Commw Scient Ind Res Org Controlled release compositions for inclusion in intraruminal devices
AU558611B2 (en) * 1981-02-03 1987-02-05 Bayer Aktiengesellschaft Polyurethane gel
US4466936A (en) * 1981-02-03 1984-08-21 Bayer Aktiengesellschaft Production of molds using gel compositions with depot action based on a polyurethane matrix and relatively high molecular weight polyols
DE3272562D1 (en) * 1981-06-12 1986-09-18 Nat Res Dev Preparation of particulate gels
DK260782A (da) * 1981-06-12 1982-12-13 Nat Res Dev Hydrogeler
ZA831186B (en) * 1982-03-22 1983-11-30 Upjohn Ltd Gelled pge2/triacetin solutions
US4443428A (en) * 1982-06-21 1984-04-17 Euroceltique, S.A. Extended action controlled release compositions
FR2539135B1 (fr) * 1983-01-11 1986-02-28 Essilor Int Hydrogels de polyurethane et procede de fabrication
GB2135881A (en) * 1983-03-02 1984-09-12 Erba Farmitalia Method and pharmaceutical compositions for inhibiting or reducing gastrointestinal side effects of non-steroidal anti-inflammatory drugs
DE3476550D1 (en) * 1983-07-21 1989-03-09 Troponwerke Gmbh & Co Kg Thermoplastics containing antiphlogistics
GB8319766D0 (en) * 1983-07-22 1983-08-24 Graham N B Controlled release device
IL72041A (en) * 1984-06-05 1990-01-18 Elka Touitou Preparation for controlled release of iodine
US5439966A (en) * 1984-07-12 1995-08-08 National Research Development Corporation Polyethylene oxide temperature - or fluid-sensitive shape memory device
FR2582944B1 (fr) * 1985-06-11 1990-10-26 Commissariat Energie Atomique Piece en polymere, notamment en polyurethane de polyoxyethylene a gonflement anisotrope, son procede de fabrication et son utilisation comme dilatateur du col uterin
EP0347145A3 (en) * 1988-06-14 1990-10-24 University Of Utah Research Foundation Heterogeneous interpenetrating polymer networks for the controlled release of drugs
US5342624A (en) * 1989-02-16 1994-08-30 British Technology Group Ltd. Dispensing device
US5225514A (en) * 1989-03-17 1993-07-06 Ono Pharmaceutical Co., Ltd. Azo containing polyurethanes for drug delivery to the large intestines
DK0398472T3 (da) * 1989-03-17 1995-01-16 Ono Pharmaceutical Co Bionedbrydelige polyurethaner
GB8918589D0 (en) * 1989-08-15 1989-09-27 Graham Neil B Polymeric compositions
US5833665A (en) * 1990-06-14 1998-11-10 Integra Lifesciences I, Ltd. Polyurethane-biopolymer composite
DK0540670T3 (da) * 1990-07-26 1996-04-29 Monsanto Co Fremgangsmåde til fremstilling af tværbundne polyaminer
AU653771B2 (en) * 1991-01-03 1994-10-13 Alkermes Controlled Therapeutics, Inc. Stabilization of proteins by cationic biopolymers
GB2254002B (en) * 1991-01-16 1995-03-22 Controlled Therapeutics Retrievable pessary
GB9101502D0 (en) * 1991-01-23 1991-03-06 Controlled Therapeutics Sct Controlled release compositions
US5273742A (en) * 1991-12-30 1993-12-28 Tyndale Plains-Hunter Ltd. Biomedical water soluble hydrophilic polyurethane polymers and method of use thereof
GB9313017D0 (en) * 1993-06-24 1993-08-11 Univ Strathclyde Measurement of water content
US5458879A (en) * 1994-03-03 1995-10-17 The Procter & Gamble Company Oral vehicle compositions
US6322815B1 (en) 1994-07-22 2001-11-27 W. Mark Saltzman Multipart drug delivery system
GB9418483D0 (en) * 1994-09-14 1994-11-02 British Tech Group Compound for use in pre-term labour
GB2295316B (en) * 1994-11-25 1997-09-10 William Leslie Porter Bolus for supplying biologically beneficial substances to ruminant animals
GB9506946D0 (en) * 1995-04-04 1995-05-24 Univ Strathclyde Microgels
US20020064546A1 (en) * 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
DE19734538C1 (de) * 1997-07-30 1998-12-24 Jenapharm Gmbh Bioadhäsive Tablette
DE69913316T2 (de) * 1998-01-07 2004-11-18 Debio Recherche Pharmaceutique S.A. Abbaubare, heterobifunktionelle polyethylenglykolacrylate, sowie damit herstellbare gele und konjugate
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
GB9826192D0 (en) * 1998-12-01 1999-01-20 Controlled Theraputics Scotlan Oral transmucosal delivery
TWI246524B (en) * 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
US7265186B2 (en) * 2001-01-19 2007-09-04 Nektar Therapeutics Al, Corporation Multi-arm block copolymers as drug delivery vehicles
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
WO2004060967A1 (en) * 2002-12-31 2004-07-22 Nektar Therapeutics Al, Corporation Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof
US7794657B2 (en) 2003-06-03 2010-09-14 Cantimer, Inc. Phase change sensor
US20040259744A1 (en) * 2003-12-19 2004-12-23 Meidong Yang Skin and hair cleansers containing sulfur
ES2299776T3 (es) * 2004-06-16 2008-06-01 Straumann Holding Ag Membrana de barrera.
US7282584B2 (en) * 2004-06-16 2007-10-16 Straumann Holding Ag Methylene blue
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
WO2006133048A2 (en) * 2005-06-03 2006-12-14 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions comprising prostanoid-receptor agonists and methods of making and using the same
EP1926768B1 (en) 2005-07-18 2011-09-14 Nektar Therapeutics Branched functionalized polymers using branched polyol cores
DE102005053066A1 (de) * 2005-11-04 2007-05-10 Basf Ag Verwendung von Copolymeren als Solubilisatoren für in Wasser schwerlöslichen Verbindungen
CN101325976A (zh) * 2005-12-09 2008-12-17 巴斯夫欧洲公司 聚乙烯基内酰胺-聚氧化烯嵌段共聚物作为微水溶性化合物的加溶剂的用途
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
CN101500583B (zh) * 2006-07-12 2012-05-23 控制治疗（苏格兰）有限公司 含克林霉素盐酸盐的药物递送聚合物
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
WO2009013202A1 (de) * 2007-07-26 2009-01-29 Basf Se Verfahren zur herstellung von durch pfropfpolymerisation in lösung erhaltenen copolymeren auf basis von polyethern in fester form
US20110045076A1 (en) 2008-01-25 2011-02-24 Kiser Patrick F Linear order release polymer
DE102009052948B4 (de) * 2009-11-12 2013-05-29 Rkw Se Silageabdeckung
WO2012149326A1 (en) 2011-04-29 2012-11-01 Massachusetts Institute Of Technology Layer processing for pharmaceuticals
GB201110601D0 (en) 2011-06-23 2011-08-03 Controlled Therapeutics Scotland Ltd Improved bioresorbable
EP2754442A1 (en) 2013-01-09 2014-07-16 Ferring B.V. Misoprostol for the induction of labour
EP2754443A1 (en) 2013-01-09 2014-07-16 Ferring B.V. Misoprostol for the induction of labour
EP2689781A1 (en) 2012-07-26 2014-01-29 Ferring B.V. Misoprostol composition
MX2015001007A (es) 2012-07-26 2015-04-09 Ferring Bv Composicion de misoprostol.
MX2015001008A (es) 2012-07-26 2015-04-09 Ferring Bv Formulacion de misoprostol.
EP2689802A1 (en) 2012-07-26 2014-01-29 Ferring B.V. Misoprostol formulation
US10213960B2 (en) * 2014-05-20 2019-02-26 Massachusetts Institute Of Technology Plasticity induced bonding
GB201916808D0 (en) 2019-11-19 2020-01-01 Ferring Bv Pharmaceutical delivery device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975350A (en) * 1972-08-02 1976-08-17 Princeton Polymer Laboratories, Incorporated Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles
FR2373279A1 (fr) * 1976-12-13 1978-07-07 Ici Ltd Composition a base d'un copolymere sequence pour la liberation prolongee d'un agent doue d'activite biologique

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1586811A (ja) * 1966-01-06 1970-03-06
US3822238A (en) * 1972-08-02 1974-07-02 Princeton Polymer Lab Hydrophilic polyurethane polymers
US3953406A (en) * 1973-01-26 1976-04-27 California Institute Of Technology Water-insoluble, swellable polyurethanes
US3993551A (en) * 1973-09-10 1976-11-23 Union Carbide Corporation Process for cocrosslinking water soluble polymers and products thereof
FR2250793B1 (ja) * 1973-11-09 1978-12-29 Commissariat Energie Atomique
GB1494814A (en) * 1976-07-14 1977-12-14 Sanyo Chemical Ind Ltd Agrochemical compositions
SE431821B (sv) * 1979-01-29 1984-03-05 Perstorp Ab Lagringsstabilt, prostaglandininnehallande medicinskt preparat

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975350A (en) * 1972-08-02 1976-08-17 Princeton Polymer Laboratories, Incorporated Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles
FR2373279A1 (fr) * 1976-12-13 1978-07-07 Ici Ltd Composition a base d'un copolymere sequence pour la liberation prolongee d'un agent doue d'activite biologique

Also Published As

Publication number Publication date
EP0016652A1 (en) 1980-10-01
DE3071070D1 (en) 1985-10-17
EP0016654A1 (en) 1980-10-01
GB2047093A (en) 1980-11-26
ATE15444T1 (de) 1985-09-15
JPS56500253A (ja) 1981-03-05
ATE14979T1 (de) 1985-09-15
JPH0323529B2 (ja) 1991-03-29
ZA801659B (en) 1981-10-28
AU537740B2 (en) 1984-07-12
AU537741B2 (en) 1984-07-12
DE3071006D1 (en) 1985-09-26
EP0016654B1 (en) 1985-09-11
NZ193222A (en) 1984-08-24
AU5669080A (en) 1980-09-25
US4894238A (en) 1990-01-16
US4931288A (en) 1990-06-05
EP0016652B1 (en) 1985-08-21
JPH0323530B2 (ja) 1991-03-29
GB2047094B (en) 1983-12-07
HK79785A (en) 1985-10-25
WO1980001985A1 (en) 1980-10-02
WO1980001984A1 (en) 1980-10-02
ZA801654B (en) 1981-10-28
NZ193221A (en) 1984-08-24
GB2047094A (en) 1980-11-26
GB2047093B (en) 1983-12-07
HK79885A (en) 1985-10-25
AU5669180A (en) 1980-09-25

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