FR2373279A1 - Composition a base d'un copolymere sequence pour la liberation prolongee d'un agent doue d'activite biologique - Google Patents
Composition a base d'un copolymere sequence pour la liberation prolongee d'un agent doue d'activite biologiqueInfo
- Publication number
- FR2373279A1 FR2373279A1 FR7737420A FR7737420A FR2373279A1 FR 2373279 A1 FR2373279 A1 FR 2373279A1 FR 7737420 A FR7737420 A FR 7737420A FR 7737420 A FR7737420 A FR 7737420A FR 2373279 A1 FR2373279 A1 FR 2373279A1
- Authority
- FR
- France
- Prior art keywords
- agent
- biological activity
- composition based
- prolonged release
- copolymer sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
- C08G18/72—Polyisocyanates or polyisothiocyanates
- C08G18/80—Masked polyisocyanates
- C08G18/8003—Masked polyisocyanates masked with compounds having at least two groups containing active hydrogen
- C08G18/8006—Masked polyisocyanates masked with compounds having at least two groups containing active hydrogen with compounds of C08G18/32
- C08G18/8009—Masked polyisocyanates masked with compounds having at least two groups containing active hydrogen with compounds of C08G18/32 with compounds of C08G18/3203
- C08G18/8012—Masked polyisocyanates masked with compounds having at least two groups containing active hydrogen with compounds of C08G18/32 with compounds of C08G18/3203 with diols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/65—Low-molecular-weight compounds having active hydrogen with high-molecular-weight compounds having active hydrogen
- C08G18/66—Compounds of groups C08G18/42, C08G18/48, or C08G18/52
- C08G18/6666—Compounds of group C08G18/48 or C08G18/52
- C08G18/667—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38
- C08G18/6674—Compounds of group C08G18/48 or C08G18/52 with compounds of group C08G18/32 or polyamines of C08G18/38 with compounds of group C08G18/3203
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S521/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S521/905—Hydrophilic or hydrophobic cellular product
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S521/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S521/914—Polyurethane cellular product formed from a polyol which has been derived from at least two 1,2 epoxides as reactants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S528/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S528/904—Isocyanate polymer having stated hydrophilic or hydrophobic property
Abstract
L'invention concerne une composition destinée à la libération prolongée d'un agent doué d'activité biologique. La composition de l'invention contient 1 un agent doué d'activité biologique, 2 un copolymère polyoxy-alkylène-polyuréthanne séquencé hydrophile linéaire sensiblement dépourvu de réticulation et présentant plusieurs régions hydrophiles et hydrophobes et 3, le cas échéant, un tampon acceptable du point de vue biologique. Application par exemple à la réalisation d'un dispositif intravaginal pour la liberation lente d'un composé abortif.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB51917/76A GB1551620A (en) | 1976-12-13 | 1976-12-13 | Delivery means for biologically active agents |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2373279A1 true FR2373279A1 (fr) | 1978-07-07 |
FR2373279B1 FR2373279B1 (fr) | 1980-06-06 |
Family
ID=10461919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7737420A Granted FR2373279A1 (fr) | 1976-12-13 | 1977-12-12 | Composition a base d'un copolymere sequence pour la liberation prolongee d'un agent doue d'activite biologique |
Country Status (18)
Country | Link |
---|---|
US (1) | US4202880A (fr) |
JP (1) | JPS5375319A (fr) |
AR (1) | AR222459A1 (fr) |
AU (1) | AU514408B2 (fr) |
BE (1) | BE861788A (fr) |
CA (1) | CA1085726A (fr) |
CH (1) | CH634996A5 (fr) |
DE (1) | DE2755505A1 (fr) |
EG (1) | EG12845A (fr) |
FR (1) | FR2373279A1 (fr) |
GB (1) | GB1551620A (fr) |
IE (1) | IE46085B1 (fr) |
IL (1) | IL53508A (fr) |
IT (1) | IT1089964B (fr) |
NL (1) | NL182777C (fr) |
NZ (1) | NZ185794A (fr) |
SE (1) | SE436685B (fr) |
ZA (1) | ZA777060B (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2447191A1 (fr) * | 1979-01-29 | 1980-08-22 | Perstorp Ab | Preparation medicale contenant de la prostaglandine et son utilisation pour application intravaginale et intracervicale |
EP0016654A1 (fr) * | 1979-03-21 | 1980-10-01 | National Research Development Corporation | Composition à libération contrôlée d'un prostaglandine et procédé pour sa préparation |
EP0092918A2 (fr) * | 1982-04-22 | 1983-11-02 | Imperial Chemical Industries Plc | Formulations à libération continue |
WO1994022934A1 (fr) * | 1993-04-01 | 1994-10-13 | British Technology Group Limited | Copolymeres en blocs aleatoires |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2087909B (en) * | 1980-11-22 | 1984-11-07 | Shirley Inst | Breathable non-porous polyurethane film |
GB2108517B (en) * | 1981-06-12 | 1985-06-12 | Nat Res Dev | Hydrogels |
US4469671A (en) * | 1983-02-22 | 1984-09-04 | Eli Lilly And Company | Contraceptive device |
US4911691A (en) * | 1984-09-21 | 1990-03-27 | Menlo Care, Inc. | Assembly for adminstering IV solution |
US4883699A (en) * | 1984-09-21 | 1989-11-28 | Menlo Care, Inc. | Polymeric article having high tensile energy to break when hydrated |
JPS6178718A (ja) * | 1984-09-25 | 1986-04-22 | Toyobo Co Ltd | 抗血栓性の優れた薬剤徐放性ポリマ−組成物 |
US4550126A (en) * | 1985-01-25 | 1985-10-29 | Hydromer, Inc. | Hydrophilic, flexible, open cell polyurethane-poly(N-vinyl lactam) interpolymer foam and dental and biomedical products fabricated therefrom |
ES2043619T3 (es) * | 1986-05-14 | 1994-01-01 | Takiron Co | Adhesivo para administracion percutanea. |
US4978391A (en) * | 1987-11-13 | 1990-12-18 | Dentsply Management Corp. | Intraoral medicament delivery and procedure |
JPH0540585Y2 (fr) * | 1988-01-13 | 1993-10-14 | ||
US5173535A (en) * | 1988-02-11 | 1992-12-22 | Dow Corning Corporation | Plastics containing sustained release of functional materials |
US4994047A (en) * | 1988-05-06 | 1991-02-19 | Menlo Care, Inc. | Multi-layer cannula structure |
US5000955A (en) * | 1988-07-29 | 1991-03-19 | Tyndale Plains-Hunter Ltd. | Thermally reversible polyurethane hydrogels and cosmetic, biological and medical uses |
US4920172A (en) * | 1989-01-30 | 1990-04-24 | Tyndale Plains-Hunter Ltd. | Hydrophilic polyurethane emulsions and materials produced therefrom |
US5342624A (en) * | 1989-02-16 | 1994-08-30 | British Technology Group Ltd. | Dispensing device |
JPH02290317A (ja) * | 1989-04-21 | 1990-11-30 | Nec Ic Microcomput Syst Ltd | フィルタ回路 |
GB8918589D0 (en) * | 1989-08-15 | 1989-09-27 | Graham Neil B | Polymeric compositions |
JPH0435519A (ja) * | 1990-05-31 | 1992-02-06 | Sanyo Electric Co Ltd | フィルタ回路 |
US5384333A (en) * | 1992-03-17 | 1995-01-24 | University Of Miami | Biodegradable injectable drug delivery polymer |
WO1993022360A1 (fr) * | 1992-04-24 | 1993-11-11 | The Polymer Technology Group, Inc. | Copolymeres et membrane non-poreuse, semi-permeable de ceux-ci, et son utilisation pour impregner des molecules presentant une plage de masses moleculaires predeterminee |
US5290418A (en) * | 1992-09-24 | 1994-03-01 | Applied Biosystems, Inc. | Viscous electrophoresis polymer medium and method |
GB9326255D0 (en) * | 1993-12-23 | 1994-02-23 | Roussel Lab Ltd | Medical device for the prevention and treatment of cancer |
AUPO251096A0 (en) | 1996-09-23 | 1996-10-17 | Cardiac Crc Nominees Pty Limited | Polysiloxane-containing polyurethane elastomeric compositions |
US6706775B2 (en) * | 2002-04-02 | 2004-03-16 | H. H. Brown Shoe Technologies, Inc. | Polyurethane foam products with controlled release of agents and additives |
GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
GB0417401D0 (en) | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
GB0613333D0 (en) * | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
GB0613638D0 (en) | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
GB0620685D0 (en) | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
US8580294B2 (en) | 2010-10-19 | 2013-11-12 | International Partnership For Microbicides | Platinum-catalyzed intravaginal rings |
US10137031B2 (en) | 2013-11-14 | 2018-11-27 | International Partnership For Microbicides, Inc. | Combination therapy intravaginal rings |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1127082B (de) * | 1959-02-26 | 1962-04-05 | Hoechst Ag | Verfahren zur Herstellung von hochmolekularen wasserloeslichen oder wasserquellbaren Polyaetherurethanen |
FR2261293A2 (fr) * | 1974-02-19 | 1975-09-12 | Grace W R & Co | |
US3923926A (en) * | 1974-01-29 | 1975-12-02 | Dai Ichi Kogyo Seiyaku Co Ltd | Thixotropic polyurethane composition |
US3953406A (en) * | 1973-01-26 | 1976-04-27 | California Institute Of Technology | Water-insoluble, swellable polyurethanes |
NL7604459A (nl) * | 1975-04-28 | 1976-11-01 | Syntex Inc | Subcutaan inplanteerbare pil. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3164565A (en) * | 1962-04-06 | 1965-01-05 | Dow Chemical Co | Water-swellable polyurethanes from a polyalkyalene ether glycol and an oxyalkylated dphenol |
DE1617393C2 (de) | 1966-01-06 | 1982-11-11 | Československá akademie věd, Praha | Verfahren zur Herstellung von biologisch aktive Stoffe enthaltenden hydrophilen vernetzten Copolymeren |
US3857932A (en) * | 1970-09-09 | 1974-12-31 | F Gould | Dry hydrophilic acrylate or methacrylate polymer prolonged release drug implants |
US3975350A (en) * | 1972-08-02 | 1976-08-17 | Princeton Polymer Laboratories, Incorporated | Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles |
US3978266A (en) * | 1972-10-05 | 1976-08-31 | Ionics Lyo Products Company | Surgical dressings |
-
1976
- 1976-12-13 GB GB51917/76A patent/GB1551620A/en not_active Expired
-
1977
- 1977-11-23 IE IE2374/77A patent/IE46085B1/en unknown
- 1977-11-28 US US05/855,332 patent/US4202880A/en not_active Expired - Lifetime
- 1977-11-28 CA CA291,890A patent/CA1085726A/fr not_active Expired
- 1977-11-28 NZ NZ185794A patent/NZ185794A/xx unknown
- 1977-11-28 ZA ZA00777060A patent/ZA777060B/xx unknown
- 1977-11-30 AU AU31065/77A patent/AU514408B2/en not_active Expired
- 1977-12-01 IL IL53508A patent/IL53508A/xx unknown
- 1977-12-09 NL NLAANVRAGE7713656,A patent/NL182777C/xx not_active IP Right Cessation
- 1977-12-12 FR FR7737420A patent/FR2373279A1/fr active Granted
- 1977-12-12 CH CH1524177A patent/CH634996A5/de not_active IP Right Cessation
- 1977-12-12 SE SE7714066A patent/SE436685B/xx not_active IP Right Cessation
- 1977-12-12 JP JP14916277A patent/JPS5375319A/ja active Granted
- 1977-12-12 AR AR270334A patent/AR222459A1/es active
- 1977-12-13 DE DE19772755505 patent/DE2755505A1/de active Granted
- 1977-12-13 IT IT30670/77A patent/IT1089964B/it active
- 1977-12-13 BE BE183401A patent/BE861788A/fr not_active IP Right Cessation
- 1977-12-13 EG EG686/77A patent/EG12845A/xx active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1127082B (de) * | 1959-02-26 | 1962-04-05 | Hoechst Ag | Verfahren zur Herstellung von hochmolekularen wasserloeslichen oder wasserquellbaren Polyaetherurethanen |
US3953406A (en) * | 1973-01-26 | 1976-04-27 | California Institute Of Technology | Water-insoluble, swellable polyurethanes |
US3923926A (en) * | 1974-01-29 | 1975-12-02 | Dai Ichi Kogyo Seiyaku Co Ltd | Thixotropic polyurethane composition |
FR2261293A2 (fr) * | 1974-02-19 | 1975-09-12 | Grace W R & Co | |
NL7604459A (nl) * | 1975-04-28 | 1976-11-01 | Syntex Inc | Subcutaan inplanteerbare pil. |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2447191A1 (fr) * | 1979-01-29 | 1980-08-22 | Perstorp Ab | Preparation medicale contenant de la prostaglandine et son utilisation pour application intravaginale et intracervicale |
EP0016654A1 (fr) * | 1979-03-21 | 1980-10-01 | National Research Development Corporation | Composition à libération contrôlée d'un prostaglandine et procédé pour sa préparation |
WO1980001985A1 (fr) * | 1979-03-21 | 1980-10-02 | M Embrey | Compositions a degagement controle (ii) |
JPS56500254A (fr) * | 1979-03-21 | 1981-03-05 | ||
US4894238A (en) * | 1979-03-21 | 1990-01-16 | National Research Development Corporation | Controlled release compositions |
US4931288A (en) * | 1979-03-21 | 1990-06-05 | Lloyds Bank Plc | Controlled release compositions (II) |
EP0092918A2 (fr) * | 1982-04-22 | 1983-11-02 | Imperial Chemical Industries Plc | Formulations à libération continue |
EP0092918A3 (en) * | 1982-04-22 | 1985-01-16 | Imperial Chemical Industries Plc | Continuous release formulations |
WO1994022934A1 (fr) * | 1993-04-01 | 1994-10-13 | British Technology Group Limited | Copolymeres en blocs aleatoires |
US7241845B2 (en) | 1993-04-01 | 2007-07-10 | Ocutec Limited | Random block copolymers |
Also Published As
Publication number | Publication date |
---|---|
AU514408B2 (en) | 1981-02-05 |
CH634996A5 (de) | 1983-03-15 |
NZ185794A (en) | 1979-03-28 |
JPS619922B2 (fr) | 1986-03-27 |
AR222459A1 (es) | 1981-05-29 |
IE46085L (en) | 1978-06-13 |
BE861788A (fr) | 1978-06-13 |
SE436685B (sv) | 1985-01-21 |
IE46085B1 (en) | 1983-02-09 |
JPS5375319A (en) | 1978-07-04 |
US4202880A (en) | 1980-05-13 |
ZA777060B (en) | 1978-09-27 |
EG12845A (en) | 1980-10-31 |
NL182777C (nl) | 1988-05-16 |
DE2755505C2 (fr) | 1987-02-26 |
SE7714066L (sv) | 1978-06-14 |
IL53508A0 (en) | 1978-03-10 |
IT1089964B (it) | 1985-06-18 |
DE2755505A1 (de) | 1978-06-15 |
AU3106577A (en) | 1979-06-07 |
GB1551620A (en) | 1979-08-30 |
IL53508A (en) | 1980-11-30 |
CA1085726A (fr) | 1980-09-16 |
FR2373279B1 (fr) | 1980-06-06 |
NL7713656A (nl) | 1978-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |