JPS5629599A - Novel 2-fluoro-o2'-monoacyl-adenosine-3',5'-cyclic phosphate, its preparation and carcinostatic agnet containing the same - Google Patents
Novel 2-fluoro-o2'-monoacyl-adenosine-3',5'-cyclic phosphate, its preparation and carcinostatic agnet containing the sameInfo
- Publication number
- JPS5629599A JPS5629599A JP10496579A JP10496579A JPS5629599A JP S5629599 A JPS5629599 A JP S5629599A JP 10496579 A JP10496579 A JP 10496579A JP 10496579 A JP10496579 A JP 10496579A JP S5629599 A JPS5629599 A JP S5629599A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- adenosine
- fluoro
- cyclic phosphate
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003327 cancerostatic effect Effects 0.000 title abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- 241000295146 Gallionellaceae Species 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 1
- GIUYCYHIANZCFB-UUOKFMHZSA-N [(2r,3s,4r,5r)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O GIUYCYHIANZCFB-UUOKFMHZSA-N 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- YHASWHZGWUONAO-UHFFFAOYSA-N butanoyl butanoate Chemical compound CCCC(=O)OC(=O)CCC YHASWHZGWUONAO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10496579A JPS5629599A (en) | 1979-08-20 | 1979-08-20 | Novel 2-fluoro-o2'-monoacyl-adenosine-3',5'-cyclic phosphate, its preparation and carcinostatic agnet containing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10496579A JPS5629599A (en) | 1979-08-20 | 1979-08-20 | Novel 2-fluoro-o2'-monoacyl-adenosine-3',5'-cyclic phosphate, its preparation and carcinostatic agnet containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5629599A true JPS5629599A (en) | 1981-03-24 |
| JPS634557B2 JPS634557B2 (enrdf_load_stackoverflow) | 1988-01-29 |
Family
ID=14394807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10496579A Granted JPS5629599A (en) | 1979-08-20 | 1979-08-20 | Novel 2-fluoro-o2'-monoacyl-adenosine-3',5'-cyclic phosphate, its preparation and carcinostatic agnet containing the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5629599A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6027395A (ja) * | 1983-07-21 | 1985-02-12 | Satoshi Shinohara | フラクトオリゴ糖の製造方法 |
| JPS61146192A (ja) * | 1984-12-17 | 1986-07-03 | Satoshi Shinohara | フラクトオリゴ糖とβ―１．３―１．６グルカンを主成分とする飲食物の製造方法 |
-
1979
- 1979-08-20 JP JP10496579A patent/JPS5629599A/ja active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6027395A (ja) * | 1983-07-21 | 1985-02-12 | Satoshi Shinohara | フラクトオリゴ糖の製造方法 |
| JPS61146192A (ja) * | 1984-12-17 | 1986-07-03 | Satoshi Shinohara | フラクトオリゴ糖とβ―１．３―１．６グルカンを主成分とする飲食物の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS634557B2 (enrdf_load_stackoverflow) | 1988-01-29 |
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