JPS5629600A - Novel 2-fluoro-n6,o2'-diacyl-adenosine-3',5'-cyclic phosphate, its preparation, and carcinostatic agent containing the same - Google Patents

Novel 2-fluoro-n6,o2'-diacyl-adenosine-3',5'-cyclic phosphate, its preparation, and carcinostatic agent containing the same

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Publication number
JPS5629600A
JPS5629600A JP10496679A JP10496679A JPS5629600A JP S5629600 A JPS5629600 A JP S5629600A JP 10496679 A JP10496679 A JP 10496679A JP 10496679 A JP10496679 A JP 10496679A JP S5629600 A JPS5629600 A JP S5629600A
Authority
JP
Japan
Prior art keywords
adenosine
fluoro
cyclic phosphate
formula
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10496679A
Other languages
Japanese (ja)
Other versions
JPS634558B2 (en
Inventor
Ayako Nasu
Nobuyuki Yamatsugu
Motohiko Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kikkoman Corp
Original Assignee
Kikkoman Corp
Kikkoman Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kikkoman Corp, Kikkoman Shoyu KK filed Critical Kikkoman Corp
Priority to JP10496679A priority Critical patent/JPS5629600A/en
Publication of JPS5629600A publication Critical patent/JPS5629600A/en
Publication of JPS634558B2 publication Critical patent/JPS634558B2/ja
Granted legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The titled cyclic phosphate expressed by formula I (R is 2W4C acyl; X is H, alkali metal or ammonium).
EXAMPLE: Sodium salt of 2-fluoro-N6,O2'-dibutyryl-adenosine-3',5'-cyclic phosphate.
USE: A carcinostatic agent with low toxicity and little side effects, and usable by intravenous injection, oral administration or application to mucous membranes in a dose of 10W60mg/kg/day for an adult.
PROCESS: 2-Fluoro-adenosine-3',5'-cyclic phosphate (salt) of formula II is reacted with an acid anhydride of formula III, e.g. butyric anhydride, preferably at 50W 70°C, to give a 2-fluoro-O2'-monoacyl-adenosine-3',5'-cyclic phosphate (salt) of formula IV, which is then reacted with a carboxylic acid of the formula ROH, e.g. butyric acid, and the acid anhydride of formula III in the presence of an inorganic acid, e.g. sulfuric acid, preferably at 90W110°C for 5W30min.
COPYRIGHT: (C)1981,JPO&Japio
JP10496679A 1979-08-20 1979-08-20 Novel 2-fluoro-n6,o2'-diacyl-adenosine-3',5'-cyclic phosphate, its preparation, and carcinostatic agent containing the same Granted JPS5629600A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10496679A JPS5629600A (en) 1979-08-20 1979-08-20 Novel 2-fluoro-n6,o2'-diacyl-adenosine-3',5'-cyclic phosphate, its preparation, and carcinostatic agent containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10496679A JPS5629600A (en) 1979-08-20 1979-08-20 Novel 2-fluoro-n6,o2'-diacyl-adenosine-3',5'-cyclic phosphate, its preparation, and carcinostatic agent containing the same

Publications (2)

Publication Number Publication Date
JPS5629600A true JPS5629600A (en) 1981-03-24
JPS634558B2 JPS634558B2 (en) 1988-01-29

Family

ID=14394837

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10496679A Granted JPS5629600A (en) 1979-08-20 1979-08-20 Novel 2-fluoro-n6,o2'-diacyl-adenosine-3',5'-cyclic phosphate, its preparation, and carcinostatic agent containing the same

Country Status (1)

Country Link
JP (1) JPS5629600A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015082723A (en) * 2013-10-22 2015-04-27 株式会社オーディオテクニカ Electret capacitor headphone unit

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015082723A (en) * 2013-10-22 2015-04-27 株式会社オーディオテクニカ Electret capacitor headphone unit

Also Published As

Publication number Publication date
JPS634558B2 (en) 1988-01-29

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