JPS56135468A - Preparation of 1- 4-hydroxyphenyl -2- 4-benzylpiperidino -1- propanol and addition salt thereof - Google Patents
Preparation of 1- 4-hydroxyphenyl -2- 4-benzylpiperidino -1- propanol and addition salt thereofInfo
- Publication number
- JPS56135468A JPS56135468A JP3822880A JP3822880A JPS56135468A JP S56135468 A JPS56135468 A JP S56135468A JP 3822880 A JP3822880 A JP 3822880A JP 3822880 A JP3822880 A JP 3822880A JP S56135468 A JPS56135468 A JP S56135468A
- Authority
- JP
- Japan
- Prior art keywords
- reaction mixture
- oxide catalyst
- platinum oxide
- product
- addition salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- UYNVMODNBIQBMV-UHFFFAOYSA-N 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol Chemical compound C1CC(CC=2C=CC=CC=2)CCN1C(C)C(O)C1=CC=C(O)C=C1 UYNVMODNBIQBMV-UHFFFAOYSA-N 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 abstract 4
- 239000003054 catalyst Substances 0.000 abstract 3
- 238000010438 heat treatment Methods 0.000 abstract 3
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 abstract 3
- 229910003446 platinum oxide Inorganic materials 0.000 abstract 3
- 239000011541 reaction mixture Substances 0.000 abstract 3
- DBOLXXRVIFGDTI-UHFFFAOYSA-N 4-benzylpyridine Chemical compound C=1C=NC=CC=1CC1=CC=CC=C1 DBOLXXRVIFGDTI-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000006227 byproduct Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000010992 reflux Methods 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000007789 gas Substances 0.000 abstract 1
- 239000011261 inert gas Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3822880A JPS56135468A (en) | 1980-03-27 | 1980-03-27 | Preparation of 1- 4-hydroxyphenyl -2- 4-benzylpiperidino -1- propanol and addition salt thereof |
| PH24937A PH16735A (en) | 1979-12-07 | 1980-12-03 | A new process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid addition salts thereof |
| GB8038771A GB2067187B (en) | 1979-12-07 | 1980-12-03 | Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid addition salts thereof |
| CA000366167A CA1141387A (en) | 1979-12-07 | 1980-12-04 | Process for the preparation of 1-(4-hydroxyphenyl)-2- (4-benzylpiperidino)-1-propanol and acid-addition salts thereof |
| US06/213,033 US4377691A (en) | 1979-12-07 | 1980-12-04 | Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid-addition salts thereof |
| FR8025923A FR2471374A1 (fr) | 1979-12-07 | 1980-12-05 | Nouveau procede pour la preparation du 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-propanol et de ses sels d'addition d'acides |
| AR283504A AR229157A1 (es) | 1979-12-07 | 1980-12-05 | Procedimiento para la preparacion de 1-(4-hidroxifenil)-2-(4-bencilpiperidino)-1-propanol |
| DE19803045916 DE3045916A1 (de) | 1979-12-07 | 1980-12-05 | Verfahren zur herstellung von 4-benzyl- (alpha) -(p-hydroxyphenyl)- (beta) -methyl-1-piperidinaethanol und seinen salzen mit saeuren |
| IT26487/80A IT1148744B (it) | 1979-12-07 | 1980-12-05 | Processo per la preparazione di 1-(4-idrossifenil)-2-(4-benzilpiperidino)-1-propanolo e relativi sali di addizione con acido |
| ES497527A ES8200342A1 (es) | 1979-12-07 | 1980-12-05 | Un procedimiento para la preparacion de 1-(4-hidroxifenil)- 2-(4-bencilpiperidino)-1-propanol |
| CH9032/80A CH648550A5 (de) | 1979-12-07 | 1980-12-08 | Verfahren zur herstellung von 4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidinaethanol und seinen salzen mit saeuren. |
| BR8008020A BR8008020A (pt) | 1979-12-07 | 1980-12-08 | Processo para a preparacao de 1-(4-hidroxifenil)-2-(4-benzilpiperidino)-1-propanol e seus sais de adicao de acido |
| AT0597580A AT374181B (de) | 1979-12-07 | 1980-12-09 | Verfahren zur herstellung von 4-benzyl-alpha-(p |
| HK71984A HK71984A (en) | 1979-12-07 | 1984-09-20 | Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1- propanol and acid-addition salts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3822880A JPS56135468A (en) | 1980-03-27 | 1980-03-27 | Preparation of 1- 4-hydroxyphenyl -2- 4-benzylpiperidino -1- propanol and addition salt thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56135468A true JPS56135468A (en) | 1981-10-22 |
| JPS6239154B2 JPS6239154B2 (enrdf_load_stackoverflow) | 1987-08-21 |
Family
ID=12519443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3822880A Granted JPS56135468A (en) | 1979-12-07 | 1980-03-27 | Preparation of 1- 4-hydroxyphenyl -2- 4-benzylpiperidino -1- propanol and addition salt thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56135468A (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01123066U (enrdf_load_stackoverflow) * | 1988-02-05 | 1989-08-22 |
-
1980
- 1980-03-27 JP JP3822880A patent/JPS56135468A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6239154B2 (enrdf_load_stackoverflow) | 1987-08-21 |
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