JPS5697270A - Preparation of 2- 4-benzylpiperidino -1- 4-hydroxyphenyl -1- propanol and addition salt thereof - Google Patents
Preparation of 2- 4-benzylpiperidino -1- 4-hydroxyphenyl -1- propanol and addition salt thereofInfo
- Publication number
- JPS5697270A JPS5697270A JP17319879A JP17319879A JPS5697270A JP S5697270 A JPS5697270 A JP S5697270A JP 17319879 A JP17319879 A JP 17319879A JP 17319879 A JP17319879 A JP 17319879A JP S5697270 A JPS5697270 A JP S5697270A
- Authority
- JP
- Japan
- Prior art keywords
- reaction mixture
- benzylpyridine
- methanol
- solvent
- hydroxypropiophenone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled substances, by brominating 4-hydroxypropiophenone in methanol as a solvent, fixing the formed hydrogen bromide with a base, heating the reaction mixture with 4-benzylpyridine under refluxing, and reducing the reaction mixture catalytically.
CONSTITUTION: 4-Hydroxypropiophenone is brominated in methanol, ethanol or ether as a solvent, and the formed hydrogen bromide is fixed with a basic substance, e.g. 4-benzylpyridine or potassium hydrogencarbonate, and 4-benzylpyridine is added simultaneously to heat the reaction mixture with methanol, etc. as a solvent under refluxing. The reaction mixture is then catalytically reduced to afford the hydrobromide of the titled substance.
EFFECT: The method is simple due to the absence of harmful substances necessary for benzylation. The reaction can be carried out in the same reaction vessel by the through process.
USE: A remedy for cerebrovascular disorder sequelae.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17319879A JPS5697270A (en) | 1979-12-30 | 1979-12-30 | Preparation of 2- 4-benzylpiperidino -1- 4-hydroxyphenyl -1- propanol and addition salt thereof |
PH24937A PH16735A (en) | 1979-12-07 | 1980-12-03 | A new process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid addition salts thereof |
GB8038771A GB2067187B (en) | 1979-12-07 | 1980-12-03 | Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid addition salts thereof |
CA000366167A CA1141387A (en) | 1979-12-07 | 1980-12-04 | Process for the preparation of 1-(4-hydroxyphenyl)-2- (4-benzylpiperidino)-1-propanol and acid-addition salts thereof |
US06/213,033 US4377691A (en) | 1979-12-07 | 1980-12-04 | Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid-addition salts thereof |
ES497527A ES8200342A1 (en) | 1979-12-07 | 1980-12-05 | Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid-addition salts thereof |
DE19803045916 DE3045916A1 (en) | 1979-12-07 | 1980-12-05 | METHOD FOR PRODUCING 4-BENZYL- (ALPHA) - (P-HYDROXYPHENYL) - (BETA) -METHYL-1-PIPERIDINAETHANOL AND ITS SALTS WITH ACIDS |
AR283504A AR229157A1 (en) | 1979-12-07 | 1980-12-05 | PROCEDURE FOR THE PREPARATION OF 1- (4-HYDROXIPHENYL) -2- (4-BENCILPIPERIDINE) -1-PROPANOL |
IT26487/80A IT1148744B (en) | 1979-12-07 | 1980-12-05 | PROCESS FOR THE PREPARATION OF 1- (4-HYDROXYPHENYL) -2- (4-BENZYLPIPERIDINE) -1-PROPANOL AND ITS ADDITION SALTS WITH ACID |
FR8025923A FR2471374A1 (en) | 1979-12-07 | 1980-12-05 | NOVEL PROCESS FOR THE PREPARATION OF 1- (4-HYDROXYPHENYL) -2- (4-BENZYLPIPERIDINO) -PROPANOL AND ITS ACID ADDITION SALTS |
BR8008020A BR8008020A (en) | 1979-12-07 | 1980-12-08 | PROCESS FOR THE PREPARATION OF 1- (4-HYDROXYphenyl) -2- (4-BENZYLPIPERIDINE) -1-PROPANOL AND ITS ACID ADDITION SALTS |
CH9032/80A CH648550A5 (en) | 1979-12-07 | 1980-12-08 | METHOD FOR PRODUCING 4-BENZYL-ALPHA- (P-HYDROXYPHENYL)-BETA-METHYL-1-PIPERIDINAETHANOL AND ITS SALTS WITH ACIDS. |
AT0597580A AT374181B (en) | 1979-12-07 | 1980-12-09 | METHOD FOR PRODUCING 4-BENZYL-ALPHA- (P |
HK71984A HK71984A (en) | 1979-12-07 | 1984-09-20 | Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid-addition salts |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17319879A JPS5697270A (en) | 1979-12-30 | 1979-12-30 | Preparation of 2- 4-benzylpiperidino -1- 4-hydroxyphenyl -1- propanol and addition salt thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5697270A true JPS5697270A (en) | 1981-08-05 |
JPS64946B2 JPS64946B2 (en) | 1989-01-10 |
Family
ID=15955912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17319879A Granted JPS5697270A (en) | 1979-12-07 | 1979-12-30 | Preparation of 2- 4-benzylpiperidino -1- 4-hydroxyphenyl -1- propanol and addition salt thereof |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5697270A (en) |
-
1979
- 1979-12-30 JP JP17319879A patent/JPS5697270A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS64946B2 (en) | 1989-01-10 |
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