JPS5697270A - Preparation of 2- 4-benzylpiperidino -1- 4-hydroxyphenyl -1- propanol and addition salt thereof - Google Patents

Preparation of 2- 4-benzylpiperidino -1- 4-hydroxyphenyl -1- propanol and addition salt thereof

Info

Publication number
JPS5697270A
JPS5697270A JP17319879A JP17319879A JPS5697270A JP S5697270 A JPS5697270 A JP S5697270A JP 17319879 A JP17319879 A JP 17319879A JP 17319879 A JP17319879 A JP 17319879A JP S5697270 A JPS5697270 A JP S5697270A
Authority
JP
Japan
Prior art keywords
reaction mixture
benzylpyridine
methanol
solvent
hydroxypropiophenone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17319879A
Other languages
Japanese (ja)
Other versions
JPS64946B2 (en
Inventor
Bonpei Yasui
Tomohisa Miyamoto
Katsuyuki Hiraoka
Yoshitaka Sako
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FUNAI CORP
Funai Pharmaceutical Industries Ltd
Original Assignee
FUNAI CORP
Funai Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FUNAI CORP, Funai Pharmaceutical Industries Ltd filed Critical FUNAI CORP
Priority to JP17319879A priority Critical patent/JPS5697270A/en
Priority to PH24937A priority patent/PH16735A/en
Priority to GB8038771A priority patent/GB2067187B/en
Priority to CA000366167A priority patent/CA1141387A/en
Priority to US06/213,033 priority patent/US4377691A/en
Priority to AR283504A priority patent/AR229157A1/en
Priority to DE19803045916 priority patent/DE3045916A1/en
Priority to ES497527A priority patent/ES8200342A1/en
Priority to IT26487/80A priority patent/IT1148744B/en
Priority to FR8025923A priority patent/FR2471374A1/en
Priority to BR8008020A priority patent/BR8008020A/en
Priority to CH9032/80A priority patent/CH648550A5/en
Priority to AT0597580A priority patent/AT374181B/en
Publication of JPS5697270A publication Critical patent/JPS5697270A/en
Priority to HK71984A priority patent/HK71984A/en
Publication of JPS64946B2 publication Critical patent/JPS64946B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled substances, by brominating 4-hydroxypropiophenone in methanol as a solvent, fixing the formed hydrogen bromide with a base, heating the reaction mixture with 4-benzylpyridine under refluxing, and reducing the reaction mixture catalytically.
CONSTITUTION: 4-Hydroxypropiophenone is brominated in methanol, ethanol or ether as a solvent, and the formed hydrogen bromide is fixed with a basic substance, e.g. 4-benzylpyridine or potassium hydrogencarbonate, and 4-benzylpyridine is added simultaneously to heat the reaction mixture with methanol, etc. as a solvent under refluxing. The reaction mixture is then catalytically reduced to afford the hydrobromide of the titled substance.
EFFECT: The method is simple due to the absence of harmful substances necessary for benzylation. The reaction can be carried out in the same reaction vessel by the through process.
USE: A remedy for cerebrovascular disorder sequelae.
COPYRIGHT: (C)1981,JPO&Japio
JP17319879A 1979-12-07 1979-12-30 Preparation of 2- 4-benzylpiperidino -1- 4-hydroxyphenyl -1- propanol and addition salt thereof Granted JPS5697270A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP17319879A JPS5697270A (en) 1979-12-30 1979-12-30 Preparation of 2- 4-benzylpiperidino -1- 4-hydroxyphenyl -1- propanol and addition salt thereof
PH24937A PH16735A (en) 1979-12-07 1980-12-03 A new process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid addition salts thereof
GB8038771A GB2067187B (en) 1979-12-07 1980-12-03 Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid addition salts thereof
CA000366167A CA1141387A (en) 1979-12-07 1980-12-04 Process for the preparation of 1-(4-hydroxyphenyl)-2- (4-benzylpiperidino)-1-propanol and acid-addition salts thereof
US06/213,033 US4377691A (en) 1979-12-07 1980-12-04 Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid-addition salts thereof
ES497527A ES8200342A1 (en) 1979-12-07 1980-12-05 Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid-addition salts thereof
DE19803045916 DE3045916A1 (en) 1979-12-07 1980-12-05 METHOD FOR PRODUCING 4-BENZYL- (ALPHA) - (P-HYDROXYPHENYL) - (BETA) -METHYL-1-PIPERIDINAETHANOL AND ITS SALTS WITH ACIDS
AR283504A AR229157A1 (en) 1979-12-07 1980-12-05 PROCEDURE FOR THE PREPARATION OF 1- (4-HYDROXIPHENYL) -2- (4-BENCILPIPERIDINE) -1-PROPANOL
IT26487/80A IT1148744B (en) 1979-12-07 1980-12-05 PROCESS FOR THE PREPARATION OF 1- (4-HYDROXYPHENYL) -2- (4-BENZYLPIPERIDINE) -1-PROPANOL AND ITS ADDITION SALTS WITH ACID
FR8025923A FR2471374A1 (en) 1979-12-07 1980-12-05 NOVEL PROCESS FOR THE PREPARATION OF 1- (4-HYDROXYPHENYL) -2- (4-BENZYLPIPERIDINO) -PROPANOL AND ITS ACID ADDITION SALTS
BR8008020A BR8008020A (en) 1979-12-07 1980-12-08 PROCESS FOR THE PREPARATION OF 1- (4-HYDROXYphenyl) -2- (4-BENZYLPIPERIDINE) -1-PROPANOL AND ITS ACID ADDITION SALTS
CH9032/80A CH648550A5 (en) 1979-12-07 1980-12-08 METHOD FOR PRODUCING 4-BENZYL-ALPHA- (P-HYDROXYPHENYL)-BETA-METHYL-1-PIPERIDINAETHANOL AND ITS SALTS WITH ACIDS.
AT0597580A AT374181B (en) 1979-12-07 1980-12-09 METHOD FOR PRODUCING 4-BENZYL-ALPHA- (P
HK71984A HK71984A (en) 1979-12-07 1984-09-20 Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid-addition salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17319879A JPS5697270A (en) 1979-12-30 1979-12-30 Preparation of 2- 4-benzylpiperidino -1- 4-hydroxyphenyl -1- propanol and addition salt thereof

Publications (2)

Publication Number Publication Date
JPS5697270A true JPS5697270A (en) 1981-08-05
JPS64946B2 JPS64946B2 (en) 1989-01-10

Family

ID=15955912

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17319879A Granted JPS5697270A (en) 1979-12-07 1979-12-30 Preparation of 2- 4-benzylpiperidino -1- 4-hydroxyphenyl -1- propanol and addition salt thereof

Country Status (1)

Country Link
JP (1) JPS5697270A (en)

Also Published As

Publication number Publication date
JPS64946B2 (en) 1989-01-10

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