JPS56115798A - 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation, and antitumor agent containing the same - Google Patents
2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation, and antitumor agent containing the sameInfo
- Publication number
- JPS56115798A JPS56115798A JP1740780A JP1740780A JPS56115798A JP S56115798 A JPS56115798 A JP S56115798A JP 1740780 A JP1740780 A JP 1740780A JP 1740780 A JP1740780 A JP 1740780A JP S56115798 A JPS56115798 A JP S56115798A
- Authority
- JP
- Japan
- Prior art keywords
- deoxy
- acetyl
- antitumor agent
- preparation
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- IMWAONMKDTZRAJ-HBNTYKKESA-N [(2r,3s,5r)-3-acetyloxy-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate Chemical class C1[C@H](OC(C)=O)[C@@H](COC(=O)C)O[C@H]1N1C(=O)NC(=O)C(F)=C1 IMWAONMKDTZRAJ-HBNTYKKESA-N 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
- -1 3-[ 2-( 2-Methoxyethoxy )benzoyl ]-2'-deoxy-3',5'-di-O-acetyl-5-fluorouridine Chemical compound 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
- PJVTZVUSBZLJOI-RNSXUZJQSA-N 1-[(2s,4s,5r)-2-acetyl-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidine-2,4-dione Chemical compound C1=C(F)C(=O)NC(=O)N1[C@@]1(C(=O)C)C[C@H](O)[C@@H](CO)O1 PJVTZVUSBZLJOI-RNSXUZJQSA-N 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000005270 trialkylamine group Chemical group 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1740780A JPS56115798A (en) | 1980-02-15 | 1980-02-15 | 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation, and antitumor agent containing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1740780A JPS56115798A (en) | 1980-02-15 | 1980-02-15 | 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation, and antitumor agent containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56115798A true JPS56115798A (en) | 1981-09-11 |
| JPS6247197B2 JPS6247197B2 (enrdf_load_stackoverflow) | 1987-10-06 |
Family
ID=11943137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1740780A Granted JPS56115798A (en) | 1980-02-15 | 1980-02-15 | 2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation, and antitumor agent containing the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56115798A (enrdf_load_stackoverflow) |
-
1980
- 1980-02-15 JP JP1740780A patent/JPS56115798A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6247197B2 (enrdf_load_stackoverflow) | 1987-10-06 |
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