JPS5551016A - Liquid for perfusion and storage of transplanting organ - Google Patents

Liquid for perfusion and storage of transplanting organ

Info

Publication number
JPS5551016A
JPS5551016A JP6958579A JP6958579A JPS5551016A JP S5551016 A JPS5551016 A JP S5551016A JP 6958579 A JP6958579 A JP 6958579A JP 6958579 A JP6958579 A JP 6958579A JP S5551016 A JPS5551016 A JP S5551016A
Authority
JP
Japan
Prior art keywords
organ
liquid
perfusion
storage
oxygen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6958579A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6210201B2 (https=
Inventor
Kazumasa Yokoyama
Masakazu Iwai
Hiroyuki Okamoto
Noboru Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
GC Biopharma Corp
Original Assignee
Green Cross Corp Japan
Green Cross Corp Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan, Green Cross Corp Korea filed Critical Green Cross Corp Japan
Publication of JPS5551016A publication Critical patent/JPS5551016A/ja
Publication of JPS6210201B2 publication Critical patent/JPS6210201B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP6958579A 1978-10-10 1979-06-04 Liquid for perfusion and storage of transplanting organ Granted JPS5551016A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/950,071 US4186253A (en) 1978-10-10 1978-10-10 Perfusate for preserving organ to be transplanted and preserving method

Publications (2)

Publication Number Publication Date
JPS5551016A true JPS5551016A (en) 1980-04-14
JPS6210201B2 JPS6210201B2 (https=) 1987-03-05

Family

ID=25489899

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6958579A Granted JPS5551016A (en) 1978-10-10 1979-06-04 Liquid for perfusion and storage of transplanting organ

Country Status (6)

Country Link
US (1) US4186253A (https=)
EP (1) EP0033402B1 (https=)
JP (1) JPS5551016A (https=)
AT (1) ATE4572T1 (https=)
AU (1) AU517547B2 (https=)
WO (1) WO1981002103A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5843934A (ja) * 1981-09-08 1983-03-14 Green Cross Corp:The ペルフルオロ化合物およびその製造方法
JPS63208572A (ja) * 1987-02-24 1988-08-30 Daikin Ind Ltd パ−フルオロ含窒素環状化合物およびその製法
JPS6490141A (en) * 1987-08-25 1989-04-06 Air Prod & Chem Perfluorobutyl derivative compound
JPH01125335A (ja) * 1987-08-25 1989-05-17 Air Prod And Chem Inc 過弗素化化合物と、はんだ付け法および液体系中の気体輸送法
KR20000023874A (ko) * 1999-04-09 2000-05-06 김욱진 고농도산소용해수액

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186253A (en) * 1978-10-10 1980-01-29 The Green Cross Corporation Perfusate for preserving organ to be transplanted and preserving method
JPS58170782A (ja) * 1982-01-22 1983-10-07 アイ・エス・シ−・ケミカルズ・リミテツド 過弗素化複素環式化合物およびこれを含むエマルシヨン
US4397870A (en) * 1982-07-27 1983-08-09 The University Of Pennsylvania Process for prolonging retention of emulsion particles in the bloodstream
US4542147A (en) * 1982-08-07 1985-09-17 The Green Cross Corporation Perfluoro-1-azatricyclic amine compound
JPS5946218A (ja) * 1982-09-09 1984-03-15 Green Cross Corp:The フルオロカ−ボン乳化製剤
CA1280082C (en) * 1984-06-22 1991-02-12 Richard L. Veech Electrolyte solutions and in vitro use thereof
JPS61502943A (ja) * 1984-06-22 1986-12-18 ビ−チ、リチャ−ド・エル 電解質溶液およびその生体内における使用
US5284645A (en) * 1987-08-05 1994-02-08 Alliance Pharmaceutical Corp. Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems
US5684050A (en) * 1986-01-24 1997-11-04 Hemagen/Pfc Stable emulsions of highly fluorinated organic compounds
US5514720A (en) * 1986-07-09 1996-05-07 Hemagen/Pfc Stable emulsions of highly fluorinated organic compounds
US5041288A (en) * 1986-05-15 1991-08-20 Emory University Method of treating tissue damaged by reperfusion injury
US5028599A (en) * 1986-05-15 1991-07-02 Emory University Method of treating mycardial damage
US5039520A (en) * 1986-05-15 1991-08-13 Emory University Plasma extender
US5152979A (en) * 1986-05-15 1992-10-06 Emory University Method for treating vascular obstructions caused by abnormal cells
US4879109A (en) * 1986-05-15 1989-11-07 Emory University Method for treating burns
US5648071A (en) * 1986-05-15 1997-07-15 Emory University Method of treating tumors
US5030448A (en) * 1986-05-15 1991-07-09 Emory University Method of delivering drugs to damaged or diseased tissue
US5250294A (en) * 1986-05-15 1993-10-05 Emory University Improved perfusion medium for transplantation of organs
US5240701A (en) * 1986-05-15 1993-08-31 Emory University Method of performing angioplasty procedures
US5182106A (en) * 1986-05-15 1993-01-26 Emory University Method for treating hypothermia
DE3751907T2 (de) * 1986-05-15 1997-04-03 Univ Emory Injizierbares Arzneimittel zum Schutz vor Gewebebeschädigung durch Ischemie
US5032394A (en) * 1986-05-15 1991-07-16 Emory University Method of treating burns
US5080894A (en) * 1986-05-15 1992-01-14 Emory University Method and composition for reducing tissue damage
US4837014A (en) * 1986-05-15 1989-06-06 Emory University An improved method of treating sickle cell anemia
US5078995A (en) * 1986-05-15 1992-01-07 Emory University Fibrionolytic composition
US4873083A (en) * 1986-05-15 1989-10-10 Emory University Fibrinolytic composition
US4997644A (en) * 1986-05-15 1991-03-05 Emory University Method of treating adult respiratory distress syndrome
US5017370A (en) * 1986-05-15 1991-05-21 Emory University Improved method of performing angioplasty procedures
US4937070A (en) * 1986-05-15 1990-06-26 Emory University Methods and compositions for treatment of pathological hydrophobic interactions in biological fluids
US4897263A (en) * 1986-05-15 1990-01-30 Emory University Methods and compositions for treatment of pathological hydrophobic interactions in biological fluids
US5064643A (en) * 1986-05-15 1991-11-12 Emory University Method for treating sickle cell disease
US5071649A (en) * 1986-05-15 1991-12-10 Emory University Method of preventing blockage in catheters
US5198211A (en) * 1986-05-15 1993-03-30 Emory University Method of treating myocardial damage
US5047236A (en) * 1986-05-15 1991-09-10 Emory University Method of treating stroke
US5089260A (en) * 1986-05-15 1992-02-18 Emory University Method of treating ischemic tissue
US4801452A (en) * 1986-05-15 1989-01-31 Hunter Robert L Fibrinolytic composition
US5674911A (en) * 1987-02-20 1997-10-07 Cytrx Corporation Antiinfective polyoxypropylene/polyoxyethylene copolymers and methods of use
US5171755A (en) * 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
US5073383A (en) * 1989-04-21 1991-12-17 Affinity Biotech, Inc. Inhibiting aggregation in fluorocarbon emulsions
US4938961A (en) * 1989-04-28 1990-07-03 Geoffrey Collins Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia
US5110722A (en) * 1989-11-09 1992-05-05 Cryolife, Inc. Cell, tissue or organ storage solution
ES2117640T3 (es) * 1990-01-17 1998-08-16 Univ California Composicion para mejorar la supervivencia de materiales biologicos.
US5358931A (en) * 1990-01-17 1994-10-25 The Regents Of The University Of California Interaction of thermal hysteresis proteins with cells and cell membranes and associated applications
JPH06500632A (ja) * 1990-08-10 1994-01-20 アナリティカル・コントロール・システムズ・インコーポレーテッド 改良された診断および治療組成物
CH683485A5 (fr) * 1990-11-20 1994-03-31 Pasteur Merieux Serums Vacc Solutions de perfusion, de conservation et de reperfusion d'organes.
US5696298A (en) * 1991-03-19 1997-12-09 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
ATE187154T1 (de) * 1991-03-19 1999-12-15 Cytrx Corp Polyoxypropylen/polyoxyethylen copolymere mit verbesserter biologischer aktivität
USRE38558E1 (en) 1991-03-19 2004-07-20 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
US5403575A (en) * 1991-12-12 1995-04-04 Hemagen/Pfc Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them
US5470568A (en) * 1992-02-13 1995-11-28 Arch Development Corporation Methods and compositions of a polymer (poloxamer) for cell repair
US5605687A (en) * 1992-05-15 1997-02-25 Arch Development Corporation Methods and compositions of a polymer (poloxamer) for repair of electrical injury
WO1994021116A1 (en) * 1993-03-16 1994-09-29 Alliance Pharmaceutical Corp. Preservation solution and method for warm organ preservation
JP2686405B2 (ja) * 1993-04-06 1997-12-08 全国農業協同組合連合会 牛受精卵の凍結保存方法
WO1995012310A1 (en) * 1993-11-02 1995-05-11 Emory University Composition for tissue and organ transplantation preservation
US5658560A (en) * 1994-01-18 1997-08-19 Serikov; Vladimir B. Method of treating endotoxemia by administering tyloxapol
US5658962A (en) 1994-05-20 1997-08-19 Minnesota Mining And Manufacturing Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
US5502094A (en) * 1994-05-20 1996-03-26 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use
US5614170A (en) * 1994-11-30 1997-03-25 Hemagen/Pfc Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (MRI)
GB9512529D0 (en) * 1995-06-20 1995-08-23 Bnfl Fluorchem Ltd Cell treatment
WO1997025978A1 (en) * 1996-01-15 1997-07-24 BELOYARTSEV, Arkady Felixovich Method of obtaining perfluorocarbon emulsions for medical purposes
SE511587C2 (sv) * 1997-07-08 1999-10-25 Sandvik Ab Sätt att tillverka skär med hål för fastspänning
US5843024A (en) 1996-05-17 1998-12-01 Breonics, Inc. Solution and process for resuscitation and preparation of ischemically damaged tissue
US6679859B1 (en) 1997-10-24 2004-01-20 Alliance Pharmaceutical Corp. Amelioration of ischemic damage using synthetic oxygen carriers
US20010055809A1 (en) * 1998-01-30 2001-12-27 Harpal S. Mangat Extending tissue preservation
AU6031599A (en) * 1998-09-09 2000-03-27 University Of Pittsburgh Improved artificial blood fluids
KR20030076593A (ko) * 2000-12-29 2003-09-26 오뜨끄리또에 악찌오네르노에 오브셰스뜨보 나우취노-쁘로이즈보드스뜨벤나야 피르마 "뻬르프또란" 가스 전달 에멀젼용 기재로서 사용되는 퍼플루오르화된사이클을 포함하는 3차 아민 및 이의 제조방법
RU2200544C1 (ru) * 2001-06-29 2003-03-20 Воробьев Сергей Иванович Способ получения стерильных перфторуглеродных эмульсий для искусственных перфторуглеродных кровезаменителей
IL273422B (en) 2004-10-07 2022-07-01 Transmedics Inc Methods and systems for extracorporeal organ treatment
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
US9078428B2 (en) * 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US8535691B2 (en) * 2006-02-16 2013-09-17 Peach Technologies, LLC. Perflurochemical treatment process and apparatus
KR100767811B1 (ko) 2006-10-25 2007-10-17 강원대학교산학협력단 이식 장기의 체외 관류방법
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US20090226876A1 (en) * 2007-11-19 2009-09-10 THE UNITED STATES GOVERMENT as represented by the DEPARTMENT OF VETERAN'S AFFAIRS Compositions And Methods For Cardiovascular Surgery
US9814230B2 (en) 2008-01-31 2017-11-14 Transmedics, Inc. Systems and methods for ex vivo lung care
US20120122816A1 (en) * 2009-02-05 2012-05-17 Resolvyx Pharmaceuticals, Inc. Compositions and methods for organ preservation
CA2756685C (en) * 2009-04-15 2019-12-24 Tenax Therapeutics, Inc. Emulsions of perfluorocarbons
US20120064178A1 (en) * 2010-09-13 2012-03-15 Carolyn Flora Anne Dean Cell-8 Solution
WO2012142487A1 (en) 2011-04-14 2012-10-18 Transmedics, Inc. Organ care solution for ex-vivo machine perfusion of donor lungs
US20130330706A1 (en) * 2012-06-06 2013-12-12 Evan C. Unger Fluid for Suspended Animation
EP2978307B1 (en) 2013-03-28 2018-12-26 The Trustees of Columbia University in the City of New York Reperfusion with omega-3 glycerides promotes donor organ protection for transplantation
CA3185937A1 (en) 2014-06-02 2015-12-10 Transmedics, Inc. Ex vivo organ care system
AU2015361996B2 (en) 2014-12-12 2019-09-26 Transmedics, Inc. Apparatus and method for organ perfusion
DK3824731T3 (da) 2015-09-09 2025-05-26 Transmedics Inc Aortakanyle til ex vivo-organplejesystem
EP4238417A3 (en) 2016-05-30 2023-12-06 Tevosol, Inc. Apparatus and method for ex vivo lung ventilation with a varying exterior pressure
EP4580680A1 (de) 2022-08-31 2025-07-09 Universität Duisburg-Essen Lecithin-modifizierte nanoskalierte sauerstoffträger (lenox)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3843455A (en) * 1972-09-13 1974-10-22 M Bier Apparatus and technique for preservation of isolated organs through perfusion
US3911138B1 (en) * 1973-02-26 1996-10-29 Childrens Hosp Medical Center Artificial blood and method for supporting oxygen transport in animals
JPS5331209B2 (https=) * 1973-10-05 1978-09-01
JPS5835485B2 (ja) * 1976-02-03 1983-08-03 株式会社ミドリ十字 酸素運搬輸液
US4186253A (en) * 1978-10-10 1980-01-29 The Green Cross Corporation Perfusate for preserving organ to be transplanted and preserving method

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5843934A (ja) * 1981-09-08 1983-03-14 Green Cross Corp:The ペルフルオロ化合物およびその製造方法
JPS63208572A (ja) * 1987-02-24 1988-08-30 Daikin Ind Ltd パ−フルオロ含窒素環状化合物およびその製法
JPS6490141A (en) * 1987-08-25 1989-04-06 Air Prod & Chem Perfluorobutyl derivative compound
JPH01125335A (ja) * 1987-08-25 1989-05-17 Air Prod And Chem Inc 過弗素化化合物と、はんだ付け法および液体系中の気体輸送法
KR20000023874A (ko) * 1999-04-09 2000-05-06 김욱진 고농도산소용해수액

Also Published As

Publication number Publication date
EP0033402B1 (en) 1983-09-07
EP0033402A1 (en) 1981-08-12
WO1981002103A1 (fr) 1981-08-06
US4186253A (en) 1980-01-29
ATE4572T1 (de) 1983-09-15
AU517547B2 (en) 1981-08-06
JPS6210201B2 (https=) 1987-03-05

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