GB1549038A - Fluorocarbon emulsions capable of carrying oxygen - Google Patents

Fluorocarbon emulsions capable of carrying oxygen

Info

Publication number
GB1549038A
GB1549038A GB27739/76A GB2773976A GB1549038A GB 1549038 A GB1549038 A GB 1549038A GB 27739/76 A GB27739/76 A GB 27739/76A GB 2773976 A GB2773976 A GB 2773976A GB 1549038 A GB1549038 A GB 1549038A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
perfluoro
alkyl
weight
tertiary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB27739/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GREEN CROSS CORP
Original Assignee
GREEN CROSS CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GREEN CROSS CORP filed Critical GREEN CROSS CORP
Publication of GB1549038A publication Critical patent/GB1549038A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The stable emulsion contains the following components: (A) At least one perfluorocarbon compound which contains 9 to 11 carbon atoms, selected from the series comprising perfluorodecalin, perfluoromethyldecalin, perfluoroalkylcyclohexane having 3 to 5 carbon atoms in the alkyl, perfluoroalkyltetrahydrofuran having 5 to 7 carbon atoms in the alkyl, perfluoroalkyltetrahydropyran having 4 to 6 carbon atoms in the alkyl and perfluoroalkanes having 9 to 11 carbon atoms; (B) At least one perfluoro-tertiary-amine having 9 to 11 carbon atoms, selected from the series comprising perfluoro-tertiaryalkylamines having 9 to 11 carbon atoms, perfluoro-N-alkylpiperidines having 4 to 6 carbon atoms in the alkyl and perfluoro-N-alkylmorpholines having 5 to 7 carbon atoms in the alkyl; a high-molecular-weight, non-ionic surfactant having a molecular weight of 2,000 to 20,000; a phospholipoid; at least one fatty acid having 8 to 22 carbon atoms or its physiologically acceptable salt or monoglyceride; the ratio by weight of the perfluorocarbon compound (A) to the perfluoro-tertiary-amine (B) being 95-50:5-50. Such an emulsion is stable even upon prolonged storage.
GB27739/76A 1976-02-03 1976-07-02 Fluorocarbon emulsions capable of carrying oxygen Expired GB1549038A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65496476A 1976-02-03 1976-02-03

Publications (1)

Publication Number Publication Date
GB1549038A true GB1549038A (en) 1979-08-01

Family

ID=24626936

Family Applications (1)

Application Number Title Priority Date Filing Date
GB27739/76A Expired GB1549038A (en) 1976-02-03 1976-07-02 Fluorocarbon emulsions capable of carrying oxygen

Country Status (22)

Country Link
JP (1) JPS5835485B2 (en)
AR (1) AR218864A1 (en)
AT (1) AT355214B (en)
BE (1) BE850992A (en)
CA (1) CA1072446A (en)
CH (1) CH633674A5 (en)
DD (1) DD132231A5 (en)
DE (1) DE2630586C2 (en)
DK (1) DK152256C (en)
ES (1) ES449635A1 (en)
FI (1) FI58071C (en)
FR (1) FR2361867A1 (en)
GB (1) GB1549038A (en)
IL (1) IL51325A (en)
LU (1) LU76698A1 (en)
MX (1) MX4136E (en)
NL (1) NL171533C (en)
NO (1) NO145370C (en)
NZ (1) NZ183096A (en)
SE (1) SE442706B (en)
SU (1) SU797546A3 (en)
ZA (1) ZA77229B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2447195A1 (en) * 1979-01-25 1980-08-22 Wada Juro CONTRAST COMPOSITION FOR ANGIOGRAPHY
GB2124104A (en) * 1982-07-27 1984-02-15 Univ Pennsylvania Perfluorochemical emulsion artificial blood
US5502094A (en) * 1994-05-20 1996-03-26 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use
US6024176A (en) * 1994-05-20 2000-02-15 3M Innovative Properties Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
EP1078636A1 (en) * 1998-05-15 2001-02-28 Chaoying Zhao Novel pharmaceutical composition for use in emergency treatment and preparation method thereof
US7357937B2 (en) 2002-09-24 2008-04-15 Therox, Inc. Perfluorocarbon emulsions with non-fluorinated surfactants
WO2010086589A3 (en) * 2009-01-30 2010-09-23 Steven Skill Apparatus for treatment of fluid streams and method of conducting the same

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186253A (en) * 1978-10-10 1980-01-29 The Green Cross Corporation Perfusate for preserving organ to be transplanted and preserving method
EP0077114B1 (en) * 1981-09-08 1987-12-02 Green Cross Corporation Perfluorochemicals, process for preparing the same and their use as blood substitutes
JPS5946218A (en) * 1982-09-09 1984-03-15 Green Cross Corp:The Fluorocarbon emulsion preparation
JPS59175421A (en) * 1983-03-24 1984-10-04 Tetsuzou Agishi Hemocathartic agent
AU2441592A (en) * 1991-08-08 1993-03-02 Leigh D. Segel Fluorocarbon blood substitute
WO1997025978A1 (en) * 1996-01-15 1997-07-24 BELOYARTSEV, Arkady Felixovich Method of obtaining perfluorocarbon emulsions for medical purposes
RU2259819C1 (en) 2004-03-01 2005-09-10 Кузнецова Ирина Николаевна Emulsion of perfluoroorganic compounds of medicinal indication and method for its obtaining
EP2005948A2 (en) 2006-03-14 2008-12-24 Sergey Ivanovich Vorobyev Perfluorocarbon gas transferring emulsion for medico-biological use, the composition and the production method thereof a medicinal agent
US8063020B2 (en) * 2007-12-22 2011-11-22 Simpkins Cuthbert O Resuscitation fluid
ES2541226B2 (en) * 2014-01-15 2016-02-12 MONDRAGÓN GOI ESKOLA POLITEKNIKOA J. Mª. ARIZMENDIARRIETA, S.C Blood phantom
RU2745290C2 (en) * 2019-04-12 2021-03-23 Ирина Николаевна Кузнецова Emulsion of perfluorocarbon compounds for biomedical purposes and a method for its production
WO2024046999A1 (en) * 2022-08-31 2024-03-07 Johann Wolfgang Goethe-Universität Frankfurt am Main Lecithin-modified nanoscale oxygen carriers (lenox)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH604490A5 (en) * 1970-09-05 1978-09-15 Green Cross Corp
JPS5331209B2 (en) * 1973-10-05 1978-09-01

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2447195A1 (en) * 1979-01-25 1980-08-22 Wada Juro CONTRAST COMPOSITION FOR ANGIOGRAPHY
US4285928A (en) * 1979-01-25 1981-08-25 Juro Wada Contrast composition for angiography
GB2124104A (en) * 1982-07-27 1984-02-15 Univ Pennsylvania Perfluorochemical emulsion artificial blood
US6214253B1 (en) 1994-05-20 2001-04-10 3M Innovative Properties Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
US6491983B2 (en) 1994-05-20 2002-12-10 3M Innovative Properties Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
US6024176A (en) * 1994-05-20 2000-02-15 3M Innovative Properties Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
US6863211B2 (en) 1994-05-20 2005-03-08 3M Innovative Properties Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
US6204299B1 (en) 1994-05-20 2001-03-20 Minnesota Mining And Manufacturing Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
US5502094A (en) * 1994-05-20 1996-03-26 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use
US6361713B1 (en) 1994-05-20 2002-03-26 3M Innovative Properties Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
US5567765A (en) * 1994-05-20 1996-10-22 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods of use
EP1078636A4 (en) * 1998-05-15 2003-07-02 Chaoying Zhao Novel pharmaceutical composition for use in emergency treatment and preparation method thereof
EP1078636A1 (en) * 1998-05-15 2001-02-28 Chaoying Zhao Novel pharmaceutical composition for use in emergency treatment and preparation method thereof
US7357937B2 (en) 2002-09-24 2008-04-15 Therox, Inc. Perfluorocarbon emulsions with non-fluorinated surfactants
US7468191B2 (en) 2002-09-24 2008-12-23 Therox, Inc. Method of preparing gas delivering perfluorocarbon emulsions with non-fluorinated surfactants
WO2010086589A3 (en) * 2009-01-30 2010-09-23 Steven Skill Apparatus for treatment of fluid streams and method of conducting the same
US9260687B2 (en) 2009-01-30 2016-02-16 Steven Skill Apparatus for treatment of fluid streams and method of conducting same

Also Published As

Publication number Publication date
NL171533C (en) 1983-04-18
CH633674A5 (en) 1982-12-31
FR2361867B1 (en) 1978-12-15
BE850992A (en) 1977-05-31
NO145370C (en) 1982-03-10
NZ183096A (en) 1979-04-26
JPS5296722A (en) 1977-08-13
NO145370B (en) 1981-11-30
FI58071B (en) 1980-08-29
FI770354A (en) 1977-08-04
DD132231A5 (en) 1978-09-13
AU1550576A (en) 1977-07-28
CA1072446A (en) 1980-02-26
DK152256B (en) 1988-02-15
FR2361867A1 (en) 1978-03-17
SU797546A3 (en) 1981-01-15
AR218864A1 (en) 1980-07-15
DK152256C (en) 1988-08-29
FI58071C (en) 1980-12-10
SE442706B (en) 1986-01-27
ATA496676A (en) 1979-07-15
DK307276A (en) 1977-08-04
JPS5835485B2 (en) 1983-08-03
NL171533B (en) 1982-11-16
DE2630586A1 (en) 1977-08-11
IL51325A (en) 1980-05-30
NO770324L (en) 1977-08-04
ES449635A1 (en) 1977-11-16
SE7607727L (en) 1977-08-04
LU76698A1 (en) 1977-06-28
NL7607514A (en) 1977-08-05
ZA77229B (en) 1977-11-30
IL51325A0 (en) 1977-03-31
AT355214B (en) 1980-02-25
MX4136E (en) 1982-01-06
DE2630586C2 (en) 1984-06-07

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
CTFF Supplementary protection certificate filed

Free format text: SPC/GB93/136, 930630

CTFG Supplementary protection certificate granted

Free format text: SPC/GB93/136, 940128, EXPIRES:20010701

PE20 Patent expired after termination of 20 years

Effective date: 19960701

CTFL Supplementary protection certificate lapsed

Free format text: SPC/GB93/136, 960701

CTFL Supplementary protection certificate lapsed

Free format text: SPC/GB93/136, 19960701