ES449635A1 - Fluorocarbon emulsions capable of carrying oxygen - Google Patents

Fluorocarbon emulsions capable of carrying oxygen

Info

Publication number
ES449635A1
ES449635A1 ES449635A ES449635A ES449635A1 ES 449635 A1 ES449635 A1 ES 449635A1 ES 449635 A ES449635 A ES 449635A ES 449635 A ES449635 A ES 449635A ES 449635 A1 ES449635 A1 ES 449635A1
Authority
ES
Spain
Prior art keywords
carbon atoms
perfluoro
alkyl
weight
tertiary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES449635A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Publication of ES449635A1 publication Critical patent/ES449635A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The stable emulsion contains the following components: (A) At least one perfluorocarbon compound which contains 9 to 11 carbon atoms, selected from the series comprising perfluorodecalin, perfluoromethyldecalin, perfluoroalkylcyclohexane having 3 to 5 carbon atoms in the alkyl, perfluoroalkyltetrahydrofuran having 5 to 7 carbon atoms in the alkyl, perfluoroalkyltetrahydropyran having 4 to 6 carbon atoms in the alkyl and perfluoroalkanes having 9 to 11 carbon atoms (B) At least one perfluoro-tertiary-amine having 9 to 11 carbon atoms, selected from the series comprising perfluoro-tertiaryalkylamines having 9 to 11 carbon atoms, perfluoro-N-alkylpiperidines having 4 to 6 carbon atoms in the alkyl and perfluoro-N-alkylmorpholines having 5 to 7 carbon atoms in the alkyl a high-molecular-weight, non-ionic surfactant having a molecular weight of 2,000 to 20,000 a phospholipoid at least one fatty acid having 8 to 22 carbon atoms or its physiologically acceptable salt or monoglyceride the ratio by weight of the perfluorocarbon compound (A) to the perfluoro-tertiary-amine (B) being 95-50:5-50. Such an emulsion is stable even upon prolonged storage.
ES449635A 1976-02-03 1976-07-07 Fluorocarbon emulsions capable of carrying oxygen Expired ES449635A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65496476A 1976-02-03 1976-02-03

Publications (1)

Publication Number Publication Date
ES449635A1 true ES449635A1 (en) 1977-11-16

Family

ID=24626936

Family Applications (1)

Application Number Title Priority Date Filing Date
ES449635A Expired ES449635A1 (en) 1976-02-03 1976-07-07 Fluorocarbon emulsions capable of carrying oxygen

Country Status (22)

Country Link
JP (1) JPS5835485B2 (en)
AR (1) AR218864A1 (en)
AT (1) AT355214B (en)
BE (1) BE850992A (en)
CA (1) CA1072446A (en)
CH (1) CH633674A5 (en)
DD (1) DD132231A5 (en)
DE (1) DE2630586C2 (en)
DK (1) DK152256C (en)
ES (1) ES449635A1 (en)
FI (1) FI58071C (en)
FR (1) FR2361867A1 (en)
GB (1) GB1549038A (en)
IL (1) IL51325A (en)
LU (1) LU76698A1 (en)
MX (1) MX4136E (en)
NL (1) NL171533C (en)
NO (1) NO145370C (en)
NZ (1) NZ183096A (en)
SE (1) SE442706B (en)
SU (1) SU797546A3 (en)
ZA (1) ZA77229B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2541226A1 (en) * 2014-01-15 2015-07-16 MONDRAGÓN GOI ESKOLA POLITEKNIKOA J. Mª. ARIZMENDIARRIETA, S.C Blood phantom (Machine-translation by Google Translate, not legally binding)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186253A (en) * 1978-10-10 1980-01-29 The Green Cross Corporation Perfusate for preserving organ to be transplanted and preserving method
JPS55100312A (en) * 1979-01-25 1980-07-31 Toshiro Wada Contrast medium for blood vessel
EP0077114B1 (en) * 1981-09-08 1987-12-02 Green Cross Corporation Perfluorochemicals, process for preparing the same and their use as blood substitutes
US4423077A (en) * 1982-07-27 1983-12-27 The University Of Pennsylvania Perfluorochemical emulsion artificial blood
JPS5946218A (en) * 1982-09-09 1984-03-15 Green Cross Corp:The Fluorocarbon emulsion preparation
JPS59175421A (en) * 1983-03-24 1984-10-04 Tetsuzou Agishi Hemocathartic agent
WO1993002653A1 (en) * 1991-08-08 1993-02-18 Segel Leigh D Fluorocarbon blood substitute
US5658962A (en) 1994-05-20 1997-08-19 Minnesota Mining And Manufacturing Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
US5502094A (en) * 1994-05-20 1996-03-26 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use
WO1997025978A1 (en) * 1996-01-15 1997-07-24 BELOYARTSEV, Arkady Felixovich Method of obtaining perfluorocarbon emulsions for medical purposes
CN1068778C (en) * 1998-05-15 2001-07-25 赵超英 Novel drug composition for treating and curing and its preparing method
US7357937B2 (en) 2002-09-24 2008-04-15 Therox, Inc. Perfluorocarbon emulsions with non-fluorinated surfactants
RU2259819C1 (en) 2004-03-01 2005-09-10 Кузнецова Ирина Николаевна Emulsion of perfluoroorganic compounds of medicinal indication and method for its obtaining
EA200801973A1 (en) 2006-03-14 2009-02-27 Сергей Иванович Воробьев PERFLUOROLEVAL GAS TRANSFER EMULSION FOR MEDICAL AND BIOLOGICAL PURPOSES, METHOD OF ITS RECEIVING AND MEANS FOR TREATMENT (OPTIONS)
US8063020B2 (en) * 2007-12-22 2011-11-22 Simpkins Cuthbert O Resuscitation fluid
GB2467353B (en) 2009-01-30 2011-07-20 Steven Skill Apparatus for treatment of fluid streams and method of conducting the same
RU2745290C2 (en) * 2019-04-12 2021-03-23 Ирина Николаевна Кузнецова Emulsion of perfluorocarbon compounds for biomedical purposes and a method for its production
WO2024046999A1 (en) * 2022-08-31 2024-03-07 Johann Wolfgang Goethe-Universität Frankfurt am Main Lecithin-modified nanoscale oxygen carriers (lenox)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH604490A5 (en) * 1970-09-05 1978-09-15 Green Cross Corp
JPS5331209B2 (en) * 1973-10-05 1978-09-01

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2541226A1 (en) * 2014-01-15 2015-07-16 MONDRAGÓN GOI ESKOLA POLITEKNIKOA J. Mª. ARIZMENDIARRIETA, S.C Blood phantom (Machine-translation by Google Translate, not legally binding)

Also Published As

Publication number Publication date
ZA77229B (en) 1977-11-30
FI770354A (en) 1977-08-04
CA1072446A (en) 1980-02-26
SU797546A3 (en) 1981-01-15
SE442706B (en) 1986-01-27
FI58071B (en) 1980-08-29
NL171533B (en) 1982-11-16
FR2361867B1 (en) 1978-12-15
FI58071C (en) 1980-12-10
IL51325A0 (en) 1977-03-31
ATA496676A (en) 1979-07-15
LU76698A1 (en) 1977-06-28
FR2361867A1 (en) 1978-03-17
DK152256B (en) 1988-02-15
AU1550576A (en) 1977-07-28
DE2630586A1 (en) 1977-08-11
MX4136E (en) 1982-01-06
DK152256C (en) 1988-08-29
NO145370B (en) 1981-11-30
NL171533C (en) 1983-04-18
BE850992A (en) 1977-05-31
SE7607727L (en) 1977-08-04
NL7607514A (en) 1977-08-05
DE2630586C2 (en) 1984-06-07
NO770324L (en) 1977-08-04
GB1549038A (en) 1979-08-01
DD132231A5 (en) 1978-09-13
CH633674A5 (en) 1982-12-31
AR218864A1 (en) 1980-07-15
DK307276A (en) 1977-08-04
NO145370C (en) 1982-03-10
JPS5835485B2 (en) 1983-08-03
JPS5296722A (en) 1977-08-13
AT355214B (en) 1980-02-25
NZ183096A (en) 1979-04-26
IL51325A (en) 1980-05-30

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