SE8300422L - EMULSION FOR USE AS PERFUSION MATERIAL - Google Patents

EMULSION FOR USE AS PERFUSION MATERIAL

Info

Publication number
SE8300422L
SE8300422L SE8300422A SE8300422A SE8300422L SE 8300422 L SE8300422 L SE 8300422L SE 8300422 A SE8300422 A SE 8300422A SE 8300422 A SE8300422 A SE 8300422A SE 8300422 L SE8300422 L SE 8300422L
Authority
SE
Sweden
Prior art keywords
emulsions
transplanted
organs
adamantane
emulsion
Prior art date
Application number
SE8300422A
Other languages
Swedish (sv)
Other versions
SE8300422D0 (en
Inventor
R E Moore
Jr L C Clark
Original Assignee
Sun Ventures Inc
Childrens Hosp Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Ventures Inc, Childrens Hosp Medical Center filed Critical Sun Ventures Inc
Publication of SE8300422L publication Critical patent/SE8300422L/en
Publication of SE8300422D0 publication Critical patent/SE8300422D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

An emulsion for flushing organs to be transplanted is described, which contains perfluorinated hydrocarbons, dispersed in water, and additionally a non-toxic emulsifier. It must contain a total of more than 40% by volume of water. The perfluorinated materials are the perfluorination products of either (1) polycyclic hydrocarbons having at least two bridge head carbon atoms linked to each other via a bridge containing at least one carbon atom and which are not adamantane, or (2) methyladamantane, ethyladamantane, ethylmethyladamantane, ethyldimethyladamantane or triethyladamantane. These perfluorination products have an excellent dissolving capacity for oxygen and carbon dioxide and they form highly stable emulsions with good resistance to the high shearing forces which are applied to the emulsions when they flow through apparatuses which load the emulsions with the necessary oxygen, which they transport to the organs to be transplanted. The emulsions permit organs which are to be transplanted to be stored for a long time, and when, on the other hand, part of the emulsions reaches the human body as the organs through which the emulsions flow are transplanted, they are not toxic there and are excreted again after some time by way of respiration and via the skin.

Claims (1)

PATENTKRAVPATENT REQUIREMENTS 1. Emulsion till anvandning son porfosionsmaterial, vilken emulsion innefattar et perfluorerad fbrening i vatten, varvid vattenmangden dr sthrre in 40 volymprocent, och varvid emulsionen innehaller ett icke toxiskt emulgermedel, kanne.teck n a d at att den perfluorerade threningen Or (1) tetrahydrodicyklopentadien eller lagre alkylderivat ddrav; 14gre alkylbicyklooktaner; 10gle alkyldiadamantaner; dimetanodekahydronaftalen eller lagre alkylderivat ddrav; tricyklononaner; eller tetrahydrobinor-S, eller (2) metyladamantan, etyladamantan, etylmetyladamantan, etyldimetyladamantan eller trietyladamantan.An emulsion for use as a perfusion material, which emulsion comprises a perfluorinated compound in water, the amount of water greater than 40% by volume, and wherein the emulsion contains a non-toxic emulsifier, which may be characterized in that the perfluorinated compound Or (1) alkyl derivative ddrav; 14gre alkylbicyclooctanes; 10gle alkyldiadamantanes; dimethanodecahydronaphthalene or lower alkyl derivative ddrav; tricyclononanes; or tetrahydrobinor-S, or (2) methyl adamantane, ethyl adamantane, ethyl methyl adamantane, ethyl dimethyl adamantane or triethyl adamantane.
SE8300422A 1974-12-09 1983-01-27 EMULSION FOR USE AS PERFUSION MATERIAL SE8300422D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53079174A 1974-12-09 1974-12-09
US57976675A 1975-05-22 1975-05-22

Publications (2)

Publication Number Publication Date
SE8300422L true SE8300422L (en) 1983-01-27
SE8300422D0 SE8300422D0 (en) 1983-01-27

Family

ID=27063372

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7513814A SE7513814L (en) 1974-12-09 1975-12-08 PERFLUORATED POLYCYCLIC ASSOCIATIONS USE AS BLOOD SUPPLYING AND PERFUSION MEDIA
SE8300422A SE8300422D0 (en) 1974-12-09 1983-01-27 EMULSION FOR USE AS PERFUSION MATERIAL

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7513814A SE7513814L (en) 1974-12-09 1975-12-08 PERFLUORATED POLYCYCLIC ASSOCIATIONS USE AS BLOOD SUPPLYING AND PERFUSION MEDIA

Country Status (12)

Country Link
JP (1) JPS5753762B2 (en)
CA (1) CA1058081A (en)
CH (1) CH629938A5 (en)
DE (1) DE2555408A1 (en)
DK (1) DK154605C (en)
FI (1) FI54560C (en)
FR (1) FR2313024A1 (en)
GB (1) GB1531418A (en)
IT (1) IT1050731B (en)
NL (1) NL184995C (en)
NO (1) NO754103L (en)
SE (2) SE7513814L (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2515198A1 (en) * 1981-10-22 1983-04-29 Centre Nat Rech Scient AQUEOUS MICROEMULSIONS OF FLUOROCARBONS INDUFINIMENTALLY STABLE AT A DATA TEMPERATURE, PROCESS FOR OBTAINING AND APPLICATION AS OXYGEN TRANSPORTERS
US4569784A (en) * 1980-11-17 1986-02-11 Adamantech, Inc. Preparation of a gel having gas transporting capability
GB8504916D0 (en) * 1985-02-26 1985-03-27 Isc Chemicals Ltd Emulsions of perfluorocarbons in aqueous media
DE4100059C2 (en) * 1991-01-03 1994-08-25 Adatomed Pharma & Med Treatment liquid for reapplication (detached) of detached retina to the choroid of the eye
WO2010077671A2 (en) * 2008-12-08 2010-07-08 University Of Utah Research Foundation Stable perfluorocarbon emulsion for use as an artificial oxygen carrier

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH604490A5 (en) * 1970-09-05 1978-09-15 Green Cross Corp
GB1343870A (en) * 1971-05-19 1974-01-16 Green Cross Corp Emulsions and the preparation thereof
US3911138B1 (en) * 1973-02-26 1996-10-29 Childrens Hosp Medical Center Artificial blood and method for supporting oxygen transport in animals
JPS5331209B2 (en) * 1973-10-05 1978-09-01

Also Published As

Publication number Publication date
NL184995C (en) 1990-01-02
DK154605B (en) 1988-12-05
FR2313024B1 (en) 1980-05-23
DK154605C (en) 1989-06-05
CH629938A5 (en) 1982-05-28
FI753442A (en) 1976-06-10
CA1058081A (en) 1979-07-10
FR2313024A1 (en) 1976-12-31
FI54560C (en) 1979-01-10
IT1050731B (en) 1981-03-20
DK554675A (en) 1976-06-10
GB1531418A (en) 1978-11-08
NL184995B (en) 1989-08-01
JPS5753762B2 (en) 1982-11-15
FI54560B (en) 1978-09-29
DE2555408A1 (en) 1976-06-10
SE7513814L (en) 1976-06-10
NO754103L (en) 1976-06-10
JPS5198318A (en) 1976-08-30
SE8300422D0 (en) 1983-01-27
DE2555408C2 (en) 1988-06-23
NL7514202A (en) 1976-06-11

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