GB1343870A - Emulsions and the preparation thereof - Google Patents

Emulsions and the preparation thereof

Info

Publication number
GB1343870A
GB1343870A GB2203572A GB2203572A GB1343870A GB 1343870 A GB1343870 A GB 1343870A GB 2203572 A GB2203572 A GB 2203572A GB 2203572 A GB2203572 A GB 2203572A GB 1343870 A GB1343870 A GB 1343870A
Authority
GB
United Kingdom
Prior art keywords
emulsion
fluorocarbon
water
surfactant
polyoxyethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2203572A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GREEN CROSS CORP
Tanabe Seiyaku Co Ltd
Original Assignee
GREEN CROSS CORP
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GREEN CROSS CORP, Tanabe Seiyaku Co Ltd filed Critical GREEN CROSS CORP
Publication of GB1343870A publication Critical patent/GB1343870A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • External Artificial Organs (AREA)
  • Colloid Chemistry (AREA)

Abstract

1343870 Fluorocarbon emulsion GREEN CROSS CORP and TANABE SEIYAKU CO Ltd 11 May 1972 [19 May 1971] 22035/72 Heading B1V [Also in Division A5] An emulsion for use as artificial blood comprises from 5 to 60% w/v of a fluorocarbon (defined) in the form of particles diameter less than 0.2 micron, 0.2 to 5% w/v one or more non-ionic surfactants and 2 to 20% w/v of one or more polyalcohols. The fluorocarbon used has S.G. 1.5 to 2.0 and is substantially insoluble in water. The emulsion may be made by dissolving the surfactant, for example polyoxyethylene-hydrogenated cator oil or a polyoxyethylene-polyoxypropylene type surfactant together with an injectable polyalcohol such as xylitol, sorbitol or glycerol in water with heating, adding the pre-heated fluorocarbon with vigorous stirring, optionally diluting with water and adjusting the pH to 7.4 then emulsifying using a high pressure emulsifier. The emulsion so prepared may be sealed into vials and sterilized. The surfactant may be purified before use by a dialysis or using ion-exchange resins.
GB2203572A 1971-05-19 1972-05-11 Emulsions and the preparation thereof Expired GB1343870A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3391171 1971-05-19

Publications (1)

Publication Number Publication Date
GB1343870A true GB1343870A (en) 1974-01-16

Family

ID=12399686

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2203572A Expired GB1343870A (en) 1971-05-19 1972-05-11 Emulsions and the preparation thereof

Country Status (6)

Country Link
CA (1) CA942191A (en)
CH (1) CH598748A5 (en)
DE (1) DE2224182A1 (en)
FR (1) FR2157774B1 (en)
GB (1) GB1343870A (en)
SE (1) SE415143B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116336A (en) * 1975-05-30 1978-09-26 Radiometer A/S Package containing a reference liquid for blood gas equipment
US4151108A (en) * 1976-01-27 1979-04-24 Radiometer A/S Reference liquid for blood gas equipment
US4163734A (en) * 1975-05-30 1979-08-07 Radiometer A/S Reference liquid for blood gas equipment
US4299728A (en) * 1980-07-21 1981-11-10 Instrumentation Laboratory Inc. Blood gas control
US4369127A (en) * 1980-07-21 1983-01-18 Instrumentation Laboratory Inc. Blood gas control

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3911138B1 (en) * 1973-02-26 1996-10-29 Childrens Hosp Medical Center Artificial blood and method for supporting oxygen transport in animals
IT1050731B (en) * 1974-12-09 1981-03-20 Childrens Hosp Medical Center PERFLUOROPOLYCLIC COMPOUNDS FOR USE AS SYNTHETIC BLOOD AND FUSION ENVIRONMENT
IT1229222B (en) * 1989-03-31 1991-07-26 Ausimont Srl STABLE EMULSIONS OF PERFLUOROPOLYETERS

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4116336A (en) * 1975-05-30 1978-09-26 Radiometer A/S Package containing a reference liquid for blood gas equipment
US4163734A (en) * 1975-05-30 1979-08-07 Radiometer A/S Reference liquid for blood gas equipment
US4151108A (en) * 1976-01-27 1979-04-24 Radiometer A/S Reference liquid for blood gas equipment
US4299728A (en) * 1980-07-21 1981-11-10 Instrumentation Laboratory Inc. Blood gas control
US4369127A (en) * 1980-07-21 1983-01-18 Instrumentation Laboratory Inc. Blood gas control

Also Published As

Publication number Publication date
DE2224182C2 (en) 1987-01-22
DE2224182A1 (en) 1972-12-21
SE415143B (en) 1980-09-15
CH598748A5 (en) 1978-05-12
FR2157774A1 (en) 1973-06-08
FR2157774B1 (en) 1976-05-14
CA942191A (en) 1974-02-19

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee