JPS5547668A - Epoxysuccinamic acid - Google Patents
Epoxysuccinamic acidInfo
- Publication number
- JPS5547668A JPS5547668A JP12102678A JP12102678A JPS5547668A JP S5547668 A JPS5547668 A JP S5547668A JP 12102678 A JP12102678 A JP 12102678A JP 12102678 A JP12102678 A JP 12102678A JP S5547668 A JPS5547668 A JP S5547668A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- phenyl
- compound
- alkyl
- alkali metal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000004365 Protease Substances 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 150000001340 alkali metals Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 108010004032 Bromelains Proteins 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 108090000526 Papain Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 101710097834 Thiol protease Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- -1 amino compound Chemical class 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- HTZXQIOCUBKYAC-UHFFFAOYSA-N ethyl 3-(phenylcarbamoyl)oxirane-2-carboxylate Chemical compound CCOC(=O)C1OC1C(=O)NC1=CC=CC=C1 HTZXQIOCUBKYAC-UHFFFAOYSA-N 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229940055729 papain Drugs 0.000 abstract 1
- 235000019834 papain Nutrition 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12102678A JPS5547668A (en) | 1978-09-30 | 1978-09-30 | Epoxysuccinamic acid |
GB7931540A GB2040919B (en) | 1978-09-30 | 1979-09-11 | Epoxysuccinamic acid compounds |
DE19792938571 DE2938571A1 (de) | 1978-09-30 | 1979-09-24 | Epoxysuccinamidsaeureverbindungen und diese verbindungen enthaltende arzneimittel |
FR7924125A FR2437408A1 (fr) | 1978-09-30 | 1979-09-27 | Procede de preparation de composes d'acide epoxysuccinamique, nouveaux produits ainsi obtenus et leur utilisation notamment pour leur activite anti-inflammatoire |
IT50404/79A IT1164826B (it) | 1978-09-30 | 1979-09-28 | Composti di acido epossisuccinammico dotati di proprieta' farmacologiche e procedimento di preparazione |
US06/263,586 US4387238A (en) | 1978-09-30 | 1981-05-14 | Epoxysuccinamic acid compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12102678A JPS5547668A (en) | 1978-09-30 | 1978-09-30 | Epoxysuccinamic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5547668A true JPS5547668A (en) | 1980-04-04 |
JPS6155509B2 JPS6155509B2 (ja) | 1986-11-28 |
Family
ID=14800966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12102678A Granted JPS5547668A (en) | 1978-09-30 | 1978-09-30 | Epoxysuccinamic acid |
Country Status (6)
Country | Link |
---|---|
US (1) | US4387238A (ja) |
JP (1) | JPS5547668A (ja) |
DE (1) | DE2938571A1 (ja) |
FR (1) | FR2437408A1 (ja) |
GB (1) | GB2040919B (ja) |
IT (1) | IT1164826B (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996030354A1 (fr) * | 1995-03-31 | 1996-10-03 | Nippon Chemiphar Co., Ltd. | Derives d'acide epoxysuccinique |
JP2015510508A (ja) * | 2012-02-01 | 2015-04-09 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | 新規のシステインプロテアーゼ阻害剤及びその使用 |
JP2016520101A (ja) * | 2013-05-31 | 2016-07-11 | インスティテュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー.エル.エー.チャイナ | 2,3−ブタンジアミドエポキシド化合物ならびにその調製方法及び使用 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57169478A (en) * | 1981-04-10 | 1982-10-19 | Nippon Chemiphar Co Ltd | Piperazine derivative |
JPS6276A (ja) * | 1985-03-26 | 1987-01-06 | Toyo Jozo Co Ltd | 酵素阻害性新規物質 |
US5545672A (en) * | 1993-02-11 | 1996-08-13 | The University Of Texas System | Treatment of insulin resistance and type 2 diabetes mellitus with a thiol protease inhibitor |
WO2003006424A1 (en) | 2001-07-10 | 2003-01-23 | 4Sc Ag | Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
EP1541198A1 (en) * | 2003-12-05 | 2005-06-15 | 4Sc Ag | Cycloalkyl compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
CN101970007A (zh) | 2007-06-08 | 2011-02-09 | 日本化学医药株式会社 | 脑动脉瘤的治疗或预防药 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS548759B2 (ja) * | 1973-03-06 | 1979-04-18 | ||
GB1469797A (en) * | 1974-11-07 | 1977-04-06 | Pfizer Ltd | Antibacterial cephalosporin derivatives |
GB1595168A (en) * | 1977-03-03 | 1981-08-12 | Taisho Pharmaceutical Co Ltd | Expoxysuccinic acid derivatives |
US4091221A (en) * | 1977-03-17 | 1978-05-23 | Shell Oil Company | 3-(Benzoyl)oxiranecarboxamides |
-
1978
- 1978-09-30 JP JP12102678A patent/JPS5547668A/ja active Granted
-
1979
- 1979-09-11 GB GB7931540A patent/GB2040919B/en not_active Expired
- 1979-09-24 DE DE19792938571 patent/DE2938571A1/de active Granted
- 1979-09-27 FR FR7924125A patent/FR2437408A1/fr active Granted
- 1979-09-28 IT IT50404/79A patent/IT1164826B/it active
-
1981
- 1981-05-14 US US06/263,586 patent/US4387238A/en not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996030354A1 (fr) * | 1995-03-31 | 1996-10-03 | Nippon Chemiphar Co., Ltd. | Derives d'acide epoxysuccinique |
JP2015510508A (ja) * | 2012-02-01 | 2015-04-09 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | 新規のシステインプロテアーゼ阻害剤及びその使用 |
US10647709B2 (en) | 2012-02-01 | 2020-05-12 | The Trustees Of Columbia University In The City Of New York | Cysteine protease inhibitors and uses thereof |
JP2016520101A (ja) * | 2013-05-31 | 2016-07-11 | インスティテュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー.エル.エー.チャイナ | 2,3−ブタンジアミドエポキシド化合物ならびにその調製方法及び使用 |
Also Published As
Publication number | Publication date |
---|---|
IT7950404A0 (it) | 1979-09-28 |
GB2040919B (en) | 1983-02-09 |
DE2938571C2 (ja) | 1988-02-18 |
IT1164826B (it) | 1987-04-15 |
JPS6155509B2 (ja) | 1986-11-28 |
FR2437408B1 (ja) | 1983-04-22 |
US4387238A (en) | 1983-06-07 |
DE2938571A1 (de) | 1980-04-17 |
GB2040919A (en) | 1980-09-03 |
FR2437408A1 (fr) | 1980-04-25 |
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